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Adult T-Cell Leukaemia/Lymphoma (A-TLL)

Adult T-cell lymphoma (A-TLL) is an aggressive type of lymphoma where the cancerous T-cells are found circulating in the blood stream. A - TLL is more common in countries such as Japan and China where a viral infection called HTLV-infection -1 is more common. HTLV-1 infection can make people more likely to develop this type of lymphoma. A-TLL can occur at any age from young adulthood to old age. It occurs slightly more often in men than in women.

What are the symptoms?

The most common symptoms include swollen lymph nodes and an enlarged liver and spleen (hepatosplenomegaly).

There may also be signs of skin involvement, high calcium levels in the blood (hypercalcaemia), bone involvement and high levels of an enzyme called lactate dehydrogenase (LDH).

Diagnosis of adult T-cell leukaemia/lymphoma is made by lymph node biopsy. X-rays, bone marrow biopsy, CT scans and blood tests may also be performed. The presence of HTLV-1 virus must also be established.

How is it treated?

Adult T-cell leukaemia/lymphoma is treated using combination chemotherapy medicines with a monoclonal antibody, targeted therapies and stem cell transplant if required.

For more information or to download our fact sheet please click here  Adult T Cell Leukaemia Lymphoma