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Clinical Trials

Clinical Trials are critical for advancing therapies for lymphoma and are a fantastic way for patients to access a certain medicine for their type of lymphoma. Clinical trials are research investigations where patients can volunteer to participate to gain access to a new medicine as a means to treat and manage their lymphoma. Clinical trials are divided into different phases and below is a table to explain the different phases and what they mean.

 Clinical Trial Phases:

Trial Type

Major Differences

Phase I

  • Tests for safety and appropriate dose of a new treatment (does not compare it with another treatment)
  • Increased risk of side effects
  • Usually includes only a small number of patients who often have advanced disease that has not responded to current treatments

Phase II

  • Tests for side effects and effectiveness of new treatment (does not compare it with another treatment)
  • Larger number of patients than a Phase I trial

Phase III

  • Further tests the new treatment on large numbers of patients once the Phase II trial has shown the treatment to be safe and effective
  • The new treatment is compared with a standard treatment to assess if the outcome is more beneficial for patients (randomised controlled trial)

Phase IV

  • Further study of the treatment after it has been approved for use in clinical practice

Video: Clinical trials in the treatment of lymphoma