About Lymphoma

Pralatrexate

Pralatrexate is an anti-cancer (chemotherapy) medicine that belongs to a group of medicines called antifolates used to treat patients with relapsed or refractory peripheral T-cell lymphoma (PTCL). Antifolates were the first type of antimetabolite drugs, the first effective chemotherapy agent discovered around 65 years ago. These drugs interfere with normal cell function.

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Indications for use in lymphoma

Pralatrexate is approved and PBS listed for public funding for:

  • The treatment of adult patients with peripheral T-cell lymphoma (nodal, extranodal, and leukaemic/disseminated) who have relapsed or have progressed after at least one prior therapy

Prior to starting pralatrexate:

10 weeks prior to the first dose of pralatrexate:

  • Hydroxocobalamin (Vit B12) 1000 micrograms intramuscularly and repeat every 8-10 weeks thereafter. Subsequent Vit B12 injections may be given the same day as pralatrexate.

Starting within the 10-day period preceding the first dose of pralatrexate:

  • Folic acid 1 mg PO once daily continuously until 30 days after the last dose of pralatrexate.

Note: Prior to starting pralatrexate patients are advised to take folic acid and B12 supplements as premedication treatment to help minimise side effects

How is it given?

  • Pralatrexate is given as an infusion into your vein over 3 to 5 minutes under the supervision of a doctor or nurse.
  • Pralatrexate is usually given once a week for 6 weeks, with no treatment on the 7th week to complete the 7-week cycle.
  • Several treatment cycles of pralatrexate may be given depending on the response to treatment.
  • Prior to being given pralatrexate, your doctor will advise to take certain medicines or vitamin supplements and whilst on treatment to help minimise side effects.

Possible side-effects

There are a number of possible side effects that can occur with pralatrexate and can include:

  • Nausea
  • Inflammation, redness, or sores of the mouth
  • Infections
  • Feeling weak and tired; fatigue
  • Fever
  • Anaemia
  • Low platelets
  • Constipation
  • Swelling

For more information

Peripheral T-cell lymphoma Fact Sheet

For more info see
EVIQ Peripheral T-cell lymphoma - pralatrexate
For more info see
Patient information - Mundipharma

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