Ka nānā 'ana o ka Lymphoma i ho'ololi 'ia (TL)
Hana ʻia ka lymphoma i hoʻololi ʻia ke hoʻololi kou lymphoma palaualelo, a lilo i lymphoma koʻikoʻi me nā hiʻohiʻona o kahi ʻano subtype o lymphoma. He ʻokoʻa kēia i kāu lymphoma palaualelo "e ala ana" a i ʻole e lilo ana i mea ʻoi aku ka ikaika a pono e mālama ʻia. I kekahi mau hihia, loaʻa paha iā ʻoe nā pūnaewele lymphoma palaualelo a paʻakikī i ka hele ʻana o ka lymphoma i ke kaʻina o ka hoʻololi ʻana.
ʻO ka maʻamau o nā lymphomas i loko o ka liʻiliʻi liʻiliʻi e ulu ana. Eia naʻe, inā hoʻomaka ka nui o kēia mau pūnaewele e ulu nui, a wikiwiki hoʻi, hoʻomaka ka lymphoma e hana e like me kahi lymphoma koʻikoʻi e like me Diffuse Large B-cell Lymphoma (DLBCL). ʻAʻole ia he mea maʻamau ke loaʻa iā ʻoe kahi lymphoma i hoʻololi ʻia, e hui pū ʻia nā sela lymphoma, ʻo kekahi poʻe molowa a me nā mea ʻē aʻe.
Nā pahuhopu o ka lapaʻau ʻana i kāu lymphoma palaualelo a i hoʻololi ʻia
ʻO ka hapa nui o nā lymphoma palaualelo e hele i nā pae e hiamoe ai a ala. Eia nō naʻe, inā ʻoi aku ka ikaika o kāu lymphoma palaualelo a pono e mālama ʻia, e loaʻa iā ʻoe nā lāʻau lapaʻau no ka mālama ʻana i kāu lymphoma palaka.
Eia nō naʻe, inā he lymphoma molowa mauuli i loko o kahi ʻano liʻiliʻi o ka lymphoma, e loaʻa paha iā ʻoe ka lāʻau lapaʻau no ka ho'ōla ʻana, a i ʻole ke kau ʻana i ka lymphoma huhū i kala ʻia.
No ke aha ka hoʻololi ʻana?
Hiki i ka Lymphoma ke hoʻololi i ka wā e hoʻomohala ai nā pūnaewele lymphoma, a i ʻole nā genes e hāʻawi i nā ʻōlelo aʻoaʻo i kāu mau cell. Hiki i kēia mau hoʻololi hou ke hopena o ka mālama anti-cancer ma mua, a i ʻole hiki ke hana me ke kumu ʻike ʻole. Hiki i nā hoʻololi genetic ke hoʻololi i ke ʻano o ka ulu ʻana a me ka hana ʻana o ka lymphoma, e hopena i kahi ʻano ʻino.
ʻO wai ka mea i hoʻopilikia ʻia e Transformed Lymphoma?
ʻO ka mea me ka lymphoma haʻahaʻa haʻahaʻa a i ʻole ka lymphoma palaualelo e pilikia i ka loli. Kakaʻikahi naʻe, a loaʻa wale ma kahi o 1 a 3 mau kānaka i kēlā me kēia 100 me ka lymphoma palaualelo i kēlā me kēia makahiki (1-3%).
E loaʻa ana iā ʻoe ka pilikia o ka hoʻololi ʻana inā loaʻa iā ʻoe maʻi nui (he maʻi ʻaʻai nui a i ʻole ka ʻōpū) i ka wā i ʻike mua ʻia ai ʻoe me kāu lymphoma palaka.
ʻO nā lymphomas indolent maʻamau e hiki ke hoʻololi i ka lymphoma B-cell e like me:
- ʻO Follicular Lymphoma
- ʻO ka maʻi maʻi maʻi Lymphocytic maʻi maʻi a i ʻole lymphoma liʻiliʻi liʻiliʻi
- ʻO Lymphoma ʻĀpana Marginal
- Nodular Lymphocyte Predominant B-cell Lymphoma (i kapa mua ʻia ʻo Nodular Lymphocyte Predominant Hodgkin Lymphoma)
- He Lymphoma Cell Mantle molowa
- ʻO Waldenstrom's Macroglobulinemia
He mea nui e hoʻomaopopo ʻaʻole loli ka hapa nui o nā poʻe me kēia lymphomas.
Hiki i kekahi poʻe me ka lymphoma T-cell molowa ke hoʻololi, akā ʻoi aku ka liʻiliʻi.
I ka manawa hea e hiki mai ai kahi hoʻololi?
Hiki ke loaʻa ka lymphoma i hoʻololi ʻia i kēlā me kēia manawa, akā loaʻa paha iā ʻoe kahi hoʻololi ma kahi o 3-6 mau makahiki ma hope o kou ʻike ʻia ʻana me kāu lymphoma palaka.
Ua emi nui ka pilikia o ka hoʻololi ʻana ma hope o kou noho ʻana me kāu lymphoma palaualelo no 15 mau makahiki, me ka loaʻa ʻole o nā loli ma hope o kēia manawa.
Ōuli e hōʻike ana paha ua loli kou lymphoma
Hiki paha iā ʻoe ke loaʻa nā hōʻailona B i ka lilo ʻana o kāu lymphoma i ʻoi aku ka ikaika a i ʻole e hoʻomaka ana e hoʻololi
He aha nā hoʻololi maʻamau?
ʻOi aku ka maʻamau o kekahi mau hoʻololi ma mua o nā mea ʻē aʻe. Ma lalo mākou e papa inoa i nā hoʻololi maʻamau (ʻoiai kakaʻikahi) hiki ke hiki.
ʻO ka lymphoma ʻaʻole |
Hiki ke hoʻololi i ka lymphoma e hiki mai ana |
| ʻO Leukemia Lymphocytic Mau Loa/Liʻi Lymphocytic Lymphoma (CLL/SLL) |
Hoʻololi i ka Diffuse Large B-cell Lymphoma (DLBCL) - ua kapa ʻia kēia hoʻololi ʻana ʻo Richter syndrome. ʻOi aku ka kakaikahi, hiki i ka CLL/SLL ke hoʻololi i ke ʻano subtype o Hodgkin Lymphoma. |
| ʻO Follicular Lymphoma |
ʻO ka hoʻololi maʻamau ka Diffuse Large B-cell Lymphoma (DLBCL). ʻOi aku ka kakaikahi, hiki ke hoʻololi i kahi lymphoma B-cell koʻikoʻi, me nā hiʻohiʻona o DLBCL a me Burkitt Lymphoma. |
| Lymphoplasmacytic Lymphoma (i kapa ʻia ʻo Waldenstrom's macroglobulinemia) | Hoʻolahalaha nui B-cell Lymphoma (DLBCL). |
| ʻO Mantle Cell Lymphoma (MCL) | Blastic (a blastoid) MCL. |
| ʻO nā Lymphomas ʻĀpana ʻāpana (MZL) | Hoʻolahalaha nui B-cell Lymphoma (DLBCL). |
| ʻO Mucosa-Associated Lymphoid Tissue Lymphoma (MALT), he ʻano liʻiliʻi o MZL | Hoʻolahalaha nui B-cell Lymphoma (DLBCL). |
| Nodular Lymphocyte-Predominant B-cell Lymphoma (i kapa mua ʻia ʻo Nodular Lymphocyte-Predominant Hodgkin lymphoma) | Lmphoma B-cell nui (DLBCL). |
| ʻO Lymphoma T-cell Cutaneous (CTCL) | ʻO Lymphoma Kelepona Nui. |
ʻO ka hōʻailona a me ke kau ʻana o ka Lymphoma i hoʻololi ʻia
Inā kānalua kāu kauka ua loli kou lymphoma, makemake lākou e hana hou i nā hoʻokolohua a me nā scans. E hoʻokomo ʻia nā hoʻāʻo ʻana i nā biopsies e nānā inā ua hoʻomohala hou nā pūnaewele lymphoma, a inā lākou e hana nei i kēia manawa e like me ke ʻano subtype o lymphoma ʻē aʻe, a ʻo nā scans e hana i ka lymphoma.
E like ana kēia mau ho'āʻo a me nā hōʻailona me nā mea āu i ʻike mua ʻia ai me ka lymphoma. ʻO ka ʻike mai kēia mau mea e hāʻawi i kāu kauka i ka ʻike e pono ai e hāʻawi iā ʻoe i ke ʻano lapaʻau maikaʻi loa no kāu lymphoma i hoʻololi ʻia.
lapaʻau
Ke pau kāu mau hopena mai ka biopsy a me ka nānā ʻana i ka staging, e nānā kāu kauka iā lākou e hoʻoholo i ka lāʻau maikaʻi loa no ʻoe. Hiki i kāu kauka ke hui pū me kahi hui o nā loea ʻē aʻe e kūkākūkā i ka lāʻau maikaʻi loa a ua kapa ʻia kēia a hui multidisciplinary (MDT) halawai.
E noʻonoʻo kāu kauka i nā kumu he nui e pili ana i kou lymphoma a me kou olakino maʻamau e hoʻoholo ai inā, a he aha ka lāʻau e pono ai. ʻO kekahi o nā mea a lākou e noʻonoʻo ai:
- He aha ka hoʻololi i hana ʻia (kāu subtype hou o lymphoma)
- ʻO ka pae o ka lymphoma
- ʻO nā hōʻailona āu e loaʻa nei
- Pehea ka hopena o ka lymphoma i kou kino
- ʻO kou makahiki
- ʻO nā pilikia olakino ʻē aʻe āu a i ʻole nā lāʻau lapaʻau āu e lawe nei
- ʻO kāu mau makemake ke loaʻa ʻoe i nā ʻike āpau āu e pono ai.
ʻAno Lapaʻau
Pono e mālama ʻia ka lymphoma i hoʻololi ʻia ma ke ʻano like me ka lymphoma huhū. Hiki ke komo i ka lāʻau lapaʻau:
- ʻO ka chemotherapy hui
- Pākuʻi monoclonal
- Ke kuʻi ʻana o ke koʻokoʻo autologous (inā lawa ke olakino)
- ʻO ke kelepona (maʻa mau me ka chemotherapy)
- CAR T-cell therapy (Chimeric antigen receptor T-cell therapy - ma hope o 2 mau lāʻau lapaʻau ma mua)
- immunotherapy
- Nā lāʻau lapaʻau i manaʻo ʻia
- Ke komo ʻana i ka hoʻokolohua lapaʻau
Ka wānana o ka Lymphoma Hoʻololi (TL)
Hiki ke ho'ōla ʻia nā lymphoma koʻikoʻi he nui, a i ʻole he mau manawa lōʻihi o ke kala ʻana ma hope o ka mālama ʻana. No laila, aia ka manaʻolana i ka wā e hāʻawi ʻia ai ka lāʻau lapaʻau hiki iā ʻoe ke ho'ōla ʻia, a i ʻole e loaʻa i ke kala lōʻihi mai ka lymphoma ʻoi aku ka ikaika, hoʻololi ʻia. Eia nō naʻe, pono ʻoe i ka hahai ʻana ma hope o kāu mālama ʻana e nānā i nā hōʻailona o ka hoʻi hou ʻana.
ʻAʻole hiki ke hoʻōla ʻia nā lymphomas indolent i ka nui o nā hihia, no laila ʻoiai ma hope o ka mālama ʻana i kāu lymphoma i hoʻololi ʻia, hiki paha iā ʻoe ke waiho i kekahi mau sela lymphoma palaka, a no laila makemake kāu kauka e nānā i kēia.
E nīnau i kāu kauka he aha kāu e ola ai, ke kala ʻana a ke noho nei me ka lymphoma palaualelo ma hope o ka mālama ʻana i kāu lymphoma i hoʻololi ʻia.
hōʻuluʻulu manaʻo
- He kakaikahi ka lymphoma i hoʻololi ʻia, me ka 1-3 wale nō o kēlā me kēia 100 poʻe me ka lymphoma palaualelo e hoʻololi i kēlā me kēia makahiki.
- ʻOi aku ka maʻamau o ka hoʻololi ʻana i ka poʻe me ka lymphoma B-cell molowa, akā hiki ke loaʻa i ka poʻe me ka lymphoma T-cell molowa pū kekahi.
- ʻOi aku ka maʻamau o ka hoʻololi ʻana ma hope o 3-6 mau makahiki ma hope o kou ʻike ʻia ʻana me kahi lymphoma palaualelo, a he mea kakaikahi loa ma hope o 15 mau makahiki.
- Hiki ke hana ʻia ka Lymphoma i hoʻololi ʻia inā hoʻomohala kāu mau genes a i ʻole lymphoma cell i nā hoʻololi hou, e hoʻololi i ke ʻano o ka ulu ʻana a me ke ʻano o ka lymphoma.
- ʻOkoʻa ʻo Lymphoma i hoʻololi ʻia me kahi lymphoma palaualelo "e ala ana" a lilo i ʻoi aku ka ikaika.
- Loaʻa ka hiki ke ho'ōla ʻia mai ka lymphoma i hoʻololi hou ʻia, akā hiki iā ʻoe ke hoʻomau i ka noho ʻana me ka lymphoma palaualelo ma hope o ka mālama ʻana.
- ʻO ka lāʻau lapaʻau no ka lymphoma i hoʻololi ʻia e hoʻopaʻa ʻia i ka hoʻōla ʻana, a i ʻole ka waiho ʻana i ka lymphoma huhū i kala ʻia.
- E hōʻike i nā mea hou a me nā mea hou aʻe nā hōʻailona, me B-hōʻailona i kāu kauka.
