Chidule cha Transformed Lymphoma (TL)
Transformed lymphoma imachitika pamene indolent lymphoma yanu ikusintha, ndipo imakhala yoopsa ya lymphoma yokhala ndi mawonekedwe amtundu wina wa lymphoma. Izi ndizosiyana ndi indolent lymphoma yanu "kudzuka" kapena kukhala wotanganidwa kwambiri ndikusowa chithandizo. Nthawi zina, mungakhale ndi maselo a lymphoma osagwira ntchito komanso achiwawa pamene lymphoma ikupita kusintha.
Indolent lymphomas nthawi zambiri amapangidwa ndi maselo ang'onoang'ono, omwe amakula pang'onopang'ono. Komabe, ngati ambiri mwa maselowa ayamba kukula, ndipo mwamsanga, lymphoma imayamba kuchita ngati lymphoma yowopsya monga Diffuse Large B-cell Lymphoma (DLBCL). Si zachilendo mukakhala ndi lymphoma yosandulika, kukhala ndi maselo osakanikirana a lymphoma, ena omwe ali osasamala komanso ena achiwawa.
Zolinga za chithandizo cha indolent kapena kusintha lymphoma
Ma lymphomas ambiri omwe ali ndi vuto amatha kudutsa magawo omwe amagona ndikudzuka. Komabe, ngati indolent lymphoma yanu iyamba kugwira ntchito ndipo ikufunika chithandizo, mudzakhala ndi chithandizo choyang'anira indolent lymphoma yanu.
Komabe, ngati muli ndi indolent lymphoma amasintha mumtundu woopsa wa lymphoma, mungakhale ndi chithandizo chochiza, kapena kuika lymphoma yowopsya kuti ikhululukidwe.
Chifukwa chiyani kusintha kumachitika?
Lymphoma ikhoza kusintha pamene maselo a lymphoma, kapena majini omwe amapereka malangizo ku maselo anu amapanga masinthidwe atsopano. Kusintha kwatsopano kumeneku kumatha kukhala chifukwa cha chithandizo cham'mbuyomu choletsa khansa, kapena zitha kuchitika popanda chifukwa chodziwika. Kusintha kwa majini kungathe kusintha momwe lymphoma imapangidwira ndi khalidwe, zomwe zimapangitsa kuti munthu akhale waukali.
Ndani amakhudzidwa ndi Transformed Lymphoma?
Aliyense amene ali ndi lymphoma yotsika kwambiri kapena indolent lymphoma ali pachiopsezo cha kusintha. Komabe ndizosowa kwambiri, ndipo zimachitika mwa anthu 1 mpaka 3 mwa 100 aliwonse omwe ali ndi indolent lymphoma chaka chilichonse (1-3%).
Mudzakhala ndi chiwopsezo chokwera pang'ono cha kusintha ngati mutero matenda aakulu (chotupa chachikulu kapena zotupa) mukangopezeka kuti muli ndi indolent lymphoma.
Ma lymphoma omwe amapezeka kwambiri omwe amatha kusintha ndi B-cell lymphoma monga:
- Lymphoma Yotsatira
- Chronic Lymphocytic Leukemia kapena Small Cell Lymphoma
- Mphepo yam'mphepete mwa Lymphoma
- Nodular Lymphocyte Predominant B-cell Lymphoma (yomwe poyamba inkatchedwa Nodular Lymphocyte Predominant Hodgkin Lymphoma)
- Mantle Cell Lymphoma ndi osasamala
- Macroglobulinemia ya Waldenstrom
Ndikofunika kumvetsetsa kuti anthu ambiri omwe ali ndi ma lymphomas sasintha.
Anthu ena omwe ali ndi T-cell lymphoma indolent angakhalenso ndi kusintha, koma izi ndizosowa.
Ndi nthawi iti pamene kusintha kungachitike?
Kusintha kwa lymphoma kumatha kuchitika nthawi iliyonse, koma nthawi zambiri mumakhala ndi kusintha kwa zaka 3-6 mutapezeka kuti muli ndi indolent lymphoma.
Kuopsa kwa kusintha kumachepa kwambiri mutakhala ndi indolent lymphoma yanu kwa zaka 15, ndipo kusintha pambuyo pa nthawiyi kumakhala kosowa kwambiri.
zizindikiro zomwe zingasonyeze kuti lymphoma yanu yasintha
Mukhozanso kupeza B-zizindikiro pamene lymphoma yanu ikuyamba kugwira ntchito kapena ikuyamba kusintha
Kodi zosintha zofala kwambiri ndi ziti?
Zosintha zina ndizofala kuposa zina. Pansipa tikulemba zosintha zofala (ngakhale sizosowa) zomwe zitha kuchitika.
Indolent lymphoma |
Ikhoza kusintha kukhala lymphoma yotsatira |
| Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) |
Kusintha Kumafalikira Large B-cell Lymphoma (DLBCL) - kusinthaku kumatchedwa Richter syndrome. Nthawi zambiri, CLL/SLL imatha kusintha kukhala gulu laling'ono la Hodgkin Lymphoma. |
| Lymphoma Yotsatira |
Kusintha kofala kwambiri ndikufalitsa Large B-cell Lymphoma (DLBCL). Nthawi zambiri, imatha kusintha kukhala B-cell lymphoma yowopsa, yokhala ndi mawonekedwe a DLBCL ndi Burkitt Lymphoma. |
| Lymphoplasmacytic Lymphoma (yomwe imatchedwanso Waldenstrom's macroglobulinemia) | Kufalitsa Large B-cell Lymphoma (DLBCL). |
| Mantle Cell Lymphoma (MCL) | Blastic (kapena blastoid) MCL. |
| Mtsinje wa Lymphomas (MZL) | Kufalitsa Large B-cell Lymphoma (DLBCL). |
| Mucosa-Associated Lymphoid Tissue Lymphoma (MALT), subtype ya MZL | Kufalitsa Large B-cell Lymphoma (DLBCL). |
| Nodular Lymphocyte-Predominant B-cell Lymphoma (yomwe poyamba inkatchedwa Nodular Lymphocyte-Predominant Hodgkin lymphoma) | Kufalitsa Large B-cell Lmphoma (DLBCL). |
| Cutaneous T-cell Lymphoma (CTCL) | Large Cell Lymphoma. |
Kuzindikira ndi kukhazikika kwa Transformed Lymphoma
Ngati dokotala akukayikira kuti lymphoma yanu yasintha adzafuna kuyesa zambiri ndikuyesa. Mayesowa aphatikizanso ma biopsies kuti awone ngati maselo a lymphoma apanga masinthidwe atsopano, komanso ngati akukhala ngati amtundu wina wa lymphoma, ndikuwunika kudzakhala kuyesa lymphoma.
Mayeserowa ndi ma scans adzakhala ofanana ndi omwe munali nawo mutapezeka kuti muli ndi lymphoma. Zambiri kuchokera pa izi zipatsa dokotala chidziwitso chofunikira kuti akupatseni chithandizo chabwino kwambiri chamankhwala osinthika a lymphoma yanu.
chithandizo
Zotsatira zanu zonse za biopsy ndi masikeloni zikamalizidwa, dokotala aziwunikanso kuti akupatseni chithandizo chabwino kwambiri. Dokotala wanu akhoza kukumananso ndi gulu la akatswiri ena kuti akambirane za chithandizo chabwino kwambiri ndipo izi zimatchedwa a Multidisciplinary team (MDT) msonkhano.
Dokotala wanu adzalingalira zambiri zokhudza lymphoma yanu ndi thanzi lanu lonse kuti asankhe ngati, ndi chithandizo chanji chomwe chikufunika. Zina mwazinthu zomwe adzaganizire ndi izi:
- Kusintha kwachitika bwanji (mtundu wanu watsopano wa lymphoma)
- Gawo la lymphoma
- Zizindikiro zilizonse zomwe mukupeza
- Momwe lymphoma imakhudzira thupi lanu
- Zaka zanu
- Mavuto ena aliwonse azachipatala omwe muli nawo kapena mankhwala omwe mukumwa
- Zokonda zanu mukapeza zonse zomwe mukufuna.
Mitundu Yamankhwala
Kusintha kwa lymphoma kumafunika kuthandizidwa mofanana ndi lymphoma yoopsa. Chithandizo chingaphatikizepo:
- Kuphatikiza chemotherapy
- Mankhwala a monoclonal
- Autologous tsinde cell kumuika (ngati wathanzi mokwanira)
- Radiotherapy (nthawi zambiri ndi chemotherapy)
- Chithandizo cha CAR T-cell (Chimeric antigen receptor T-cell therapy - pambuyo pa chithandizo cha 2 choyambirira)
- immunotherapy
- Mankhwala ochizira
- Kutenga nawo gawo pazachipatala
Kuzindikira kwa Transformed Lymphoma (TL)
Ma lymphoma ambiri owopsa amatha kuchiritsidwa, kapena amakhala ndi nthawi yayitali yakukhululukidwa akalandira chithandizo. Chifukwa chake, pali chiyembekezo kuti mukapatsidwa chithandizo mutha kuchiritsidwa, kapena kukhala ndi chikhululukiro chokhalitsa kuchokera ku lymphoma yoopsa kwambiri, yosinthika. Komabe, mufunikabe kutsatiridwa bwino mukatha kulandira chithandizo kuti muwone ngati mukuyambiranso.
Indolent lymphomas nthawi zambiri sangathe kuchiritsidwa, kotero ngakhale mutalandira chithandizo cha lymphoma yanu yosinthidwa, mungakhalebe ndi maselo a indolent lymphoma omwe atsala, motero dokotala wanu adzafunanso kufufuza izi.
Funsani dokotala wanu mwayi woti muchiritsidwe, kupita kuchikhululukiro ndikukhalabe ndi indolent lymphoma mutalandira chithandizo cha lymphoma yanu yosinthidwa.
Chidule
- Transformed lymphoma ndiyosowa kwambiri, ndipo pafupifupi 1-3 mwa anthu 100 aliwonse omwe ali ndi indolent lymphoma amakhala ndi kusintha chaka chilichonse.
- Kusinthidwa kumakhala kofala kwambiri mwa anthu omwe ali ndi B-cell lymphoma yosasamala, koma imatha kuchitika mwa anthu omwe ali ndi T-cell lymphoma indolent.
- Kusintha kumakhala kofala pakadutsa zaka 3-6 mutapezeka kuti muli ndi indolent lymphoma, ndipo ndizosowa kwambiri pakatha zaka 15.
- Kusintha kwa Lymphoma kungatheke ngati majini anu kapena maselo a lymphoma apanga masinthidwe atsopano, kusintha momwe lymphoma imakulira ndi kuchitira.
- Transformed Lymphoma ndi yosiyana ndi indolent lymphoma "kudzuka" ndikukhala yogwira ntchito.
- Palinso mwayi wochiritsidwa kuchokera ku lymphoma yosinthika kwambiri, koma mukhoza kupitiriza kukhala ndi indolent lymphoma mutalandira chithandizo.
- Kuchiza kwa lymphoma yosinthidwa kudzayang'aniridwa ndi kuchiritsa, kapena kuika lymphoma yaukali kuti ikhululukidwe.
- Nenani zonse zatsopano ndi zoyipa zizindikirokuphatikizapo B-zizindikiro kwa dokotala wanu.
