Marginal Zone Lymphoma (SMZL)
SMZL is a type of indolent B-cell NHL
that predominantly involves the spleen. It is a rare type of lymphoma
accounting for less than 1% of all NHL. It most commonly occurs in adults and
slightly more frequently in women than in men.
What are the symptoms?
Symptoms do not normally appear until
years after the disease has begun. The most common symptom is an enlarged
spleen (splenomegaly). Unlike many other types of NHL, there are normally no
swollen lymph nodes.
There is usually involvement of the
blood and bone marrow at the time of diagnosis, with the only other symptom
Diagnosis is based on identification
of the cell type together with the typical clinical findings. A biopsy of the
bone marrow can often confirm diagnosis however removal of the spleen
(splenectomy) is occasionally required for tissue examination.
How is it treated?
A number of different approaches may
be taken with SMZL, including Watch and Wait, removal of the spleen
(splenectomy), radiotherapy, chemotherapy medicines with a monoclonal antibody
and targeted therapies.