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Anaplastic Large Cell Lymphoma (ALCL): Systemic-Type and Primary Cutaneous-Type

ALCL Anaplastic refers to the appearance of the lymphoma cells, which look quite different from normal lymphocytes. ALCL can occur in two different forms:

Occurring throughout the body - "systemic “type

Occurring in the skin only - primary cutaneous type

ALCL systemic-type

ALCL is an aggressive lymphoma, whereas the primary cutaneous type follows a more indolent course.

Patients with ALCL are typically aged in their thirties and approximately 70% are male.

What are the symptoms?

ALCL systemic-type:

ALCL systemic - type has enlarged lymph nodes, as well as involvement of other organs. Systemic symptoms and elevated levels of the enzyme lactate dehydrogenase (LDH) occur in approximately 50% of people. Bone marrow and the gastrointestinal tract are rarely involved, but skin involvement is common.

For more information download our ALCL fact sheet here