Kuwana kuti une lymphoma inogona kuva nguva inonetsa zvikuru, asi kuva neruzivo rwakakodzera kunogona kubatsira kuderedza kushushikana kwako uye kukubatsira kuronga mberi. Iri peji rinokupa muchidimbu kuti chii chinonzi lymphoma, kuti masero anowanzokura sei, uye nei lymphoma inokura, zviratidzo zve lymphoma uye kurapwa kwayo pamwe chete nehukama hunobatsira.
Lymphoma imhando yekenza inobata masero ako eropa anonzi lymphocytes. Lymphocytes imhando yemasero machena eropa anotsigira immune system yedu nekurwisa hutachiona uye zvirwere. Ivo kazhinji vanogara mu lymphatic system yedu ine mashoma mashoma anowanikwa muropa redu. Nemhaka yokuti vanogara zvakanyanya mu lymphatic system yedu, lymphoma kazhinji hairatidzi pakuongorora ropa.
Yedu lymphatic system ine basa rekuchenesa ropa redu remuchetura uye tsvina uye inosanganisira lymph nodes yedu, spleen, thymus, tonsils, appendix uye mvura inonzi lymph. Yedu lymphatic system ndiyo zvakare maB-cell lymphocytes edu anoita zvirwere zvinorwisa masoja ekudzivirira chirwere.
Lymphomas yakanzi kenza yeropa, kenza ye lymphatic system uye kenza ye immune system. Asi pane kuve mhando nhatu dzegomarara, aya mazwi anopa izvo, kupi uye sei. Dzvanya paflip mabhokisi pazasi kuti udzidze zvakawanda.
The What
The What
B-masero, ayo anoita masoja ekudzivirira chirwere.
T-masero anogona kurwisa hutachiona zvakananga uye kutora mamwe maseru ekudzivirira.
NK masero - rudzi rwemhando yeT-cell.
The Where
The Where
The How
The How
Izvi zvinokanganisa simba remasoja emuviri wako kukuchengetedza hutano uye kukudzivirira kubva kuhutachiona nezvirwere.
Kana usati, ungada kushanyira peji redu rewebhu paKunzwisisa yako lymphatic system uye immune system nekudzvanya link iri pazasi. Kunzwisisa yako lymphatic uye immune system ichakubatsira iwe kunzwisisa lymphoma zvishoma nyore.
Tine marudzi maviri makuru e-lymphocytes:
- B-cell lymphocytes uye
- T-cell lymphocytes.
Izvi zvinoreva kuti unogona kuva neB-cell lymphoma kana T-cell lymphoma. Mamwe ma lymphoma asingawanzo nzi Natural Killer cell (NK) lymphomas - NK masero imhando yeT-cell lymphocyte.
Lymphoma inobatanidzwa zvakare muHodgkin Lymphoma uye Non-Hodgkin Lymphoma.
Ndeupi musiyano uripo pakati peHodgkin neNon-Hodgkin Lymphoma?
- Hodgkin Lymphoma - ose Hodgkin Lymphomas ari lymphomas B-cell lymphocytes. Hodgkin Lymphoma inotaridzwa kana B-masero ane gomarara achikura neimwe nzira ova Reed-Sternberg masero - izvo zvinotaridzika zvakasiyana zvakanyanya kubva kune akajairwa B-seli. Reed-Sternberg masero haapo muNon-Hodgkin Lymphomas. Masero eReed Sterberg anewo imwe protein inonzi CD15 kana CD30 paari. Click pano kuti udzidze zvakawanda nezveHodgkin lymphoma.
- Non-Hodgkin Lymphoma (NHL) - idzi lymphomas mamwe ose B-masero kana T-cell lymphocytes, kusanganisira NK masero. Chronic Lymphocytic Leukemia (CLL) inonziwo subtype yeNHL sezvo iri chirwere chakafanana ne Diki Lymphocytic Lymphoma. Kune anopfuura 75 akasiyana subtypes eNHL. Kuti udzidze zvakawanda nezve akasiyana subtypes, tinya chinongedzo pazasi.
Kuti unzwisise lymphoma, iwe unofanirwa kutanga waziva zvishoma nezvekuti masero ari mumuviri wako anokura sei.
Masero anowanzokura sei?
Kazhinji maseru anokura uye kuwanda nenzira yakanyatso kudzorwa uye yakarongeka. Iwo akarongedzerwa kukura uye kuzvibata neimwe nzira, uye kuwanda kana kufa pane dzimwe nguva.
Masero ega ane microscopic - zvichireva kuti madiki zvekuti hatikwanise kuaona. Asi, kana zvese zvabatana zvinoumba nhengo dzese dzemuviri wedu kusanganisira ganda redu, nzara, mapfupa, bvudzi, lymph nodes, ropa uye nhengo dzemuviri.
Kune akawanda macheki nemabharanzi anoitika kuti ave nechokwadi chekuti masero anokura nenzira kwayo. Izvi zvinosanganisira "immune checkpoints". Midziyo yekutarisa mapoinzi panguva yekukura kwesero uko immune system yedu "inotarisa" kuti sero ishe, rine hutano sero.
Kana sero rikatariswa uye rikawanikwa riine hutano, rinoramba richikura. Kana iine hosha, kana kukuvadzwa neimwe nzira, inogadziriswa kana kuparadzwa (inofa), uye inobviswa mumuviri wedu kuburikidza ne lymphatic system yedu.
- Kana masero awanda, inonzi "cell division".
- Kana masero afa anonzi "apoptosis".
Iyi nzira yekuparadzaniswa kwesero uye apoptosis inodzorwa nemajini muDNA yedu, uye iri kuitika mumiviri yedu nguva dzese. Isu tinogadzira matiririyoni emasero zuva rega rega kutsiva ekare anenge apedza basa rawo kana kukuvara.
Genes uye DNA
Mukati mesero rega rega (kunze kwemasero matsvuku eropa) mune nucleus ine mapeya makumi maviri nematatu emakromosomes.
MaChromosomes anoumbwa neDNA yedu, uye DNA yedu inoumbwa nemajini akawanda akasiyana ayo anopa "recipe" yekuti masero edu anofanira kukura sei, kuwanda, kushanda uye pakupedzisira kufa.
Kenza, kusanganisira lymphoma uye CLL inoitika apo kukuvara kana kukanganisa kunoitika mumajeni edu.
Dzidza zvakawanda pamusoro pezvinoitika kana majini edu neDNA zvakuvadzwa muvhidhiyo iri pasi apa. Usanetseka zvakanyanya pamusoro pemazita ese emapuroteni uye maitiro, mazita haana kukosha sezvaanoita.
Chii chinonzi cancer?
Gomarara iri genechirwere cheta. Zvinoitika kana kukanganisa kana kukanganisa kunoitika mukati medu genes, zvichikonzera kukura kusina kujairika, kusingadzoreki kwemasero.
Mune lymphoma neCLL, kukura kusingadzoreki uye kusiri kwemaitiro kunoitika mune yako T-cell kana B-cell lymphocytes.
Idzi shanduko kuDNA yedu dzimwe nguva dzinonzi genetic mutations kana genetic variations. Zvinogona kuitika nekuda kwemararamiro akadai sekuputa, kukuvadzwa nezuva, kunwa doro zvakanyanya (kuwanikwa shanduko), kana nekuda kwezvirwere zvinomhanya mumhuri dzedu (kugarwa nhaka). Asi kune mamwe magomarara, isu hatingozive kuti sei zvichiitika.
Chii chinokonzera Lymphoma & CLL
Lymphoma neCLL ndeimwe yemhando dzegomarara kwatisingazive kuti chii chinodzikonzera. Pane zvimwe zvinhu zvine njodzi zvakave zvichionekwa, asi vanhu vazhinji vane njodzi imwecheteyo havaenderere mberi nekuvandudza lymphoma kana CLL nepo vamwe, pasina chimwe chezvinozivikanwa zvinokonzeresa.
Dzimwe njodzi dzinogona kusanganisira:
- Kana iwe wakambove neEpstein Barr virus (EBV). EBV inokonzera mononucleosis (inozivikanwawo se "mono" kana glandular fever).
- Human immunodeficiency virus (HIV).
- Zvimwe zvirwere zve immune system yako, senge autoimmune lymphoproliferative syndrome.
- Kudzikira immune system mushure menhengo kana stem cell transplant. Kana, kubva kune mimwe mishonga yaungave uchitora.
- Mubereki, mukoma, kana hanzvadzi ine nhoroondo yega ye lymphoma.
Kutsvakurudza kwakawanda kunodiwa kuti uone zvikonzero zve lymphoma neCLL. Kana chikonzero chazivikanwa, ipapo tinogona kuwana nzira dzekudzivirira. Asi kusvika panguva iyoyo, kuziva nezvezviratidzo zve lymphoma, uye kuona chiremba kare ndiyo mukana wakanakisisa wekurwisa.
Kuongorora kweLymphoma uye CLL
Lymphoma inobata vanhu vanopfuura zviuru mazana manomwe nemazana matatu evaAustralia gore rega rega, uye ndiyo kenza yechitanhatu inowanikwa muvarume nevakadzi vakuru muAustralia, asi inogona kubata vanhu vemazera ese kusanganisira vana nevacheche.
Ndiro gomarara rinonyanya kuitika muvechidiki vane makore 15-29 ekuberekwa, uye igomarara rechitatu muvana vane makore 3-0 ekuberekwa. Zvisinei, njodzi yekuvandudza lymphoma inowedzera sezvatinokura.
Chii chandinofanira kuziva nezve lymphoma yangu?
Kune anopfuura 80 akasiyana subtypes e-lymphoma. Mamwe ma subtypes akajairika, uye mamwe mashoma. Anopfuura makumi manomwe neshanu eaya madiki ari subtype yeNon-Hodgkin Lymphoma, nepo mashanu ari madiki eHodgkin Lymphoma.
Zvakakosha kuziva kuti ndeupi subtype yaunayo, nokuti izvi zvinogona kukanganisa rudzi rwekurapa rungangoshanda zvakanyanya kwauri, uye kuti lymphoma ichafambira mberi sei uye pasina kurapwa. Ichakubatsira kuronga mberi, kuziva zvaunotarisira uye kukubatsira kubvunza chiremba wako mibvunzo yakarurama.
Lymphomas inobatanidzwazve kuita indolent kana aggressive lymphomas.
Indolent Lymphoma
Indolent lymphomas inononoka kukura lymphomas inowanzo "kurara" uye isingakure. Izvi zvinoreva kuti dziripo mumuviri wako, asi hadzisi kukuvadza. Mazhinji indolent lymphomas haadi chero kurapwa - kunyanya kana akarara. Kunyangwe imwe nhanho yepamusoro, indolent lymphomas senge nhanho 3 uye nhanho 4 inogona kusada kurapwa, kana isiri kukonzera zviratidzo uye isiri kushingaira kukura.
Yakawanda indolent lymphomas haigone kurapwa, saka iwe uchava ne lymphoma kwehupenyu hwako hwose. Asi, vanhu vazhinji vanogona kurarama hupenyu hwakakwana uye hupenyu hurefu neine indolent lymphoma.
Iwe unogona kunge usina zviratidzo zvinoonekwa kana uine indolent lymphoma, uye unogona kugara nayo kwemakore akawanda pasina matambudziko. Kune vamwe vanhu, zvinogona kusatomboonekwa kusvika iwe kuna chiremba uye kuongororwa chimwe chinhu.
Mumwe muvanhu vashanu vane indolent lymphoma haazombodi kurapwa kwe lymphoma yavo. Nekudaro, indolent lymphomas inogona "kumuka" uye kutanga kukura. Kana izvi zvikaitika, ungangoda kutanga kurapwa. Zvakakosha kuti iwe uudze chiremba wako kana iwe uchitanga kuwana zviratidzo semapundu matsva kana kukura (kuzvimba lymph nodes) kana B-zviratidzo Kusanganisira:
- Kunyorova usiku dikita
- Kuonda kusingatarisirwi
- Tembiricha ine kana isina kutonhora uye kuzununguka.
Muzviitiko zvisingawanzoitiki, indolent lymphoma inogona "kushandura" kuva ine hutsinye subtype ye lymphoma. Kana izvi zvikaitika iwe uchapiwa kurapwa kwakafanana kune aggressive lymphoma.
Pazasi pane runyorwa rweakawanda akajairika B-cell uye T-cell indolent lymphomas. Kana iwe uchiziva yako subtype, uye yakanyorwa pano, unogona kudzvanya pairi kuti uwane rumwe ruzivo.
Indolent (inononoka kukura) B-cell NHL
Indolent (inononoka kukura) T-cell NHL
Aggressive Lymphomas
Aggressive T-cell lymphomas inogona kunge yakaoma kurapa, uye iwe unogona kuwana kuregererwa mushure mekurapa. Zvisinei, zvinowanzoitika kuti T-cell lymphomas idzoke zvakare uye inoda zvimwe, kana kuramba ichirapwa.
Zvakakosha kutaura nachiremba wako pamusoro pezvinotarisirwa nemishonga yako, uye kuti iwe unogona sei kuporeswa kana kupinda mukuregererwa.
Kurapa kweLymphoma uye CLL
Nemhaka yemhando dzakasiyana-siyana dze lymphoma, kunewo marudzi akasiyana-siyana ekurapa. Paunenge uchiita chirongwa chako chekurapa chiremba wako achafunga nezve zvese izvi zvinosanganisira:
- Ndeipi subtype uye nhanho ye lymphoma yaunayo.
- Chero genetic mutations iwe ungave uine.
- Zera rako, hutano hwese uye kumwe kurapwa kwaungave uchitora kune zvimwe zvirwere.
- Kunyangwe iwe wakave nekurapa kwe lymphoma munguva yakapfuura uye kana zvakadaro, wakaita sei kune iyo kurapwa.
Mibvunzo kuna chiremba wako
Zvinogona kukurira kuziva kuti une lymphoma kana CLL. Uye, kana iwe usingazive zvausingazive, ungaziva sei mibvunzo yekubvunza?
Kukubatsira kuti utange tabatanidza mimwe mibvunzo yaunogona kudhinda uye kuenda nayo kumusangano wako unotevera. Ingobaya chinongedzo pazasi kurodha mibvunzo yedu yekubvunza chiremba wako.
Pane mamwe marudzi egomarara reropa here?
Tine marudzi akasiyana emasero machena eropa anoita mabasa akasiyana mukurwisa utachiona nezvirwere. Lymphoma igomarara remasero machena eropa anonzi lymphocytes. Asi nekuti tine marudzi akasiyana emasero machena eropa, mamwe marudzi egomarara reropa aripo, kusanganisira leukemia nemyeloma.
Leukemia
Leukemia inokanganisa marudzi akasiyana emasero machena eropa. Masero asina kujairika anokura mumwongo kana muropa. Neleukemia, masero eropa haagadzirwe sezvaanofanira kuitwa. Panogona kunge paine akawanda, mashoma, kana masero eropa asingashande sezvaanofanira kuita.
Leukemia inogona kurongwa nemhando yewhite cell yakabatwa, ingave myeloid cell kana lymphatic cell, uye kuti chirwere chinokura sei. Acute leukemia inokura nekukurumidza uye inoda kurapwa ipapo, nepo chronic leukemia inokura nekufamba kwenguva, uye inogona kusada kurapwa.
Kuti uwane rumwe ruzivo ndapota ona iyo Leukemia Foundation Webhusaiti.
Myeloma
Myeloma igomarara reimwe nyanzvi, uye yakanyanya kukura yeB-cell lymphocyte - inonzi plasma cell. Iro plasma cell inogadzira masoja ekudzivirira chirwere (anonziwo immunoglobulins). Nokuti masero eplasma ane basa rakakosha, myeloma inorongwa zvakasiyana kune lymphomas.
Mu myeloma, masero eplasma asina kujairika anoita rudzi rumwe chete rwemasoja anonzi paraprotein. Iyi paraprotein haina basa rinobatsira, uye kana masero eplasma akawandisa asina kujairika akaungana mumwongo wako, muviri wako unogona kuwana zvakaoma kurwisa hutachiona.
Kuti uwane rumwe ruzivo ndapota ona iyo Myeloma Australia Webhusaiti.
pfupiso
- Lymphoma imhando yegomarara reropa rinobata masero machena anonzi lymphocytes.
- Lymphocytes anogara zvakanyanya mu lymphatic system yedu uye anotsigira immune system yedu nekurwisa hutachiona uye zvirwere.
- Lymphoma inotanga apo kuchinja kweDNA yedu kunoguma nekusagadziriswa uye kukura kusina kujairika kwekenza lymphoma masero.
- Hodgkin Lymphoma uye Non-Hodgkin Lymphoma ndiwo marudzi makuru e-lymphoma, asi anotsanangurwa zvakare seB-cell kana T-cell lymphomas, uye indolent kana aggressive lymphomas.
- Kune akawanda marudzi akasiyana ekurapa uye chinangwa chekurapa chinotsamira pane subtype ye lymphoma yaunayo.
- Kana iwe usingazivi subtype ye lymphoma yako, kana kukosha kwe subtype yako, bvunza chiremba wako.
