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Ezinye iintlobo zeLymphoma

Cofa apha ukujonga ezinye iintlobo ze-lymphoma

Inkqubo yasePrayimari yeNervous Lymphoma (PCNSL)

Inkqubo ye-nervous central lymphoma, efinyeziweyo njenge-PCNSL, inqabileyo, i-aggressive (ekhula ngokukhawuleza) i-sub-type ye-non-Hodgkin lymphoma (NHL), ekhula kwingqondo kunye / okanye intambo yomgogodla. Ixhaphake kakhulu kubantu abaneminyaka engama-50 kunye nama-60 ubudala kodwa ingenzeka nakweyiphi na iminyaka.

Kuxhaphake kakhulu ukuba i-PCNSL ibe sengqondweni yakho, kodwa inokuba kuyo nayiphi na indawo ye-CNS yakho. Malunga ne-1 kuma-50 amathumba engqondo luhlobo lwe-CNS lymphoma.

I-lumbar puncture ingasetyenziselwa ukujonga i-lymphoma kwinkqubo yakho ye-nervous central, okanye ukuhambisa ichemotherapy kwi-cerebral spinal fluid.

I-Lymphoma ngumhlaza weeseli ezimhlophe zegazi ezibizwa ngokuba yi-lymphocytes kwaye inokuchazwa njengodidi lweHodgkin, okanye i-Non-Hodgkin Lymphoma. I-primary central nervous system lymphoma (PCNSL) luhlobo olunqabileyo, olunobundlobongela lwe-Non-Hodgkin Lymphoma efumaneka kwinkqubo yakho ye-nervous central (CNS) equka ingqondo yakho, intambo yomgogodla kunye namehlo. I-lymphocyte ezinomhlaza kwi-PCNSL zibizwa ngokuba yi-B-cell lymphocytes.

Eli phepha lewebhu liza kukunika ulwazi oludingayo ukuba ufumana naziphi na iimpawu kunye neempawu, kwinkqubo yokufumana ukuxilongwa, ukuqala unyango lwe-PCNSL, okanye ukuba nemiphumo eqhelekileyo ehambelana nonyango lwe-PCNSL.

Kweli phepha:

I-Primary central nervous system lymphoma (PCNSL) fact sheet PDF

Isishwankathelo se-PCNSL

I-PCNSL ikhula xa umhlaza we-B-cell lymphocytes (i-B-cell) zenza kwi-lymphoid tissue yengqondo kunye / okanye intambo yomgogodla. I-PCNSL inokuqalisa kwakhona kwiileyile ezenza isigqubuthelo sangaphandle sobuchopho (i-meninges) okanye emehlweni (i-ocular lymphoma). 

Ngamanye amaxesha i-lymphoma ingaqala kwezinye iindawo zomzimba kwaye isasazeke kwi-CNS. Oku akuhambisani ne-PCNSL kwaye iphathwa ngendlela eyahlukileyo. Ukuba sele iqalile ngaphandle kwe-CNS kwaye isasazeka kwi-CNS ibizwa ngokuba yi-secondary CNS lymphoma.

Isizathu se-PCNSL asaziwa njengokuba kunjalo kwi-lymphomas ezininzi. Abantu banokuchaphazeleka ngakumbi phakathi kweminyaka engama-50 ukuya kuma-60 ubudala, kunye nobudala obuqhelekileyo bokuxilongwa malunga neminyaka engama-60, nangona kunjalo ingenzeka nakweyiphi na iminyaka. I-PCNSL iphinde ixhaphake kancinane kubantu abanesistim somzimba esibuthathaka, esinokubangelwa:

  • Usulelo lwe-HIV (human immunodeficiency virus) – oku akuqhelekanga ngoku ngenxa yokufumaneka konyango olusebenzayo lwe-antiviral.
  • Amayeza – lawo asetyenziselwa ukucinezela amajoni omzimba, njengasemva koqhaqho lofakelo lwelungu okanye ezinye iintlobo zonyango lwe-immunosuppressive kwiimeko ze-autoimmune umz. isifo samathambo.

Ngaba i-PCNSL iyanyangeka?

Uninzi lwe-lymphomas enoburhalarhume lunokusabela kakuhle kunyango lwechemotherapy kuba ichemotherapy isebenza ngokubulala iiseli ezikhula ngokukhawuleza. Kukho izinto ezininzi nangona kunjalo, ezichaphazela ukuba uya kuphiliswa kwi-lymphoma yakho okanye hayi. Abantu abaninzi banokunyangeka, abanye banokuba namaxesha oxolelo - apho kungekho phawu lwe-lymphoma eseleyo emzimbeni wakho, kodwa ke inokuphinda ibuyele (ibuye) kwaye idinga unyango olongezelelweyo.

Ukufumana ulwazi oluthe kratya malunga namathuba akho onyango, thetha nogqirha wakho wegazi okanye i-oncologist.

Yintoni eyenziwa yiCentral Nervous System (CNS)?

The Inkqubo ye-nervous central (CNS) lilungu lomzimba wethu elilawula yonke imisebenzi yethu yomzimba. Iquka ingqondo yethu, umnqonqo kunye namehlo.

Ingqondo

Ingqondo yethu yenziwe:

  • Icerebrum - oku kulawula intetho kunye nokuqonda kwethu, iimvakalelo zethu kunye nentshukumo yokuzithandela (iintshukumo esigqiba ukuzenza)
  • Cerebellum - inceda ngeentshukumo kwaye ilawula ibhalansi yethu
  • Inkqubo yeBrain – ilawula imisebenzi ebalulekileyo yomzimba, njengokuphefumla kwethu, izinga lokubetha kwentliziyo kunye noxinzelelo lwegazi

Umnqonqo

Intambo yethu yomqolo ibaleka isuka kwingqondo yethu ihle ngasemva ngaphakathi kwamathambo omqolo. Uthotho lwemithambo-luvo lujoyina ngokuthe ngqo kwintambo yomqolo. Imithambo-luvo ithwala ulwazi malunga nemvakalelo evela kumzimba wonke kwaye ithwala imiyalezo isiya kwaye isuka kwingqondo yethu iyise kuwo wonke umzimba wethu, ukulawula izihlunu zethu, kunye nayo yonke imisebenzi yemizimba yethu.

Ikhuselwe njani i-CNS yethu?

I-CNS yethu yahluliwe kuwo wonke umzimba wethu kwaye ikhuselwe kumonzakalo, usulelo kunye nezifo ngeendlela ezininzi.

  • The ukuthetha zizinto ezikhuselayo zeethishu ezigqume ingqondo kunye nentambo yomnqonqo – yiyo le nto idumba kwi-'meningitis'.
  • Ulwelo olukhethekileyo olubizwa ngokuba 'ulwelo lwe-cerebrospinal'(CSF) ijikeleze ingqondo kunye nentambo yomnqonqo ukuzikhubaza - ifumaneka kwisithuba esiphakathi kwe-meninges kunye nengqondo kunye nentambo yomgogodla.
  • The isithintelo segazi-nengqondo ijikeleze ingqondo yethu - ngumqobo weeseli kunye nemithambo yegazi evumela kuphela izinto ezithile ukuba zifike engqondweni. Oku kuyayikhusela kwiikhemikhali eziyingozi kunye nosulelo, kwaye ikwathintela okanye iphazamisana neyeza ezininzi zechemotherapy ezidlula egazini zisiya ebuchotsheni.
Ukuqonda i-PCNSL kufuneka ukwazi kancinci malunga ne-B-Cell lymphocytes yakho.

I-B-Cell lymphocytes:

  • Ngaba luhlobo lweseli emhlophe yegazi
  • Ukulwa usulelo kunye nezifo ukuze uhlale usempilweni. 
  • Khumbula usulelo obunalo kwixesha elidlulileyo, ngoko ke ukuba ufumana usulelo olufanayo kwakhona, amajoni omzimba wakho angalwa nalo ngempumelelo kwaye ngokukhawuleza. 
  • Zenziwe kumongo wethambo lakho (inxalenye ye-spongy embindini wamathambo akho), kodwa ihlala ihlala kwinkqubo yakho ye-lymphatic ebandakanya yakho: 
  1. ithumba
  2. iinqanawa ze-lymphatic kunye ne-lymph fluid
  3. amalungu - udaka, thymus, tonsils, appendix
  4. izicubu ze-lymphoid
  • Unokuhamba nge-lymphatic system yakho, ukuya kulo naliphi na ilungu lomzimba wakho ukulwa usulelo okanye izifo. 
Inkqubo yakho ye-lymphatic yinxalenye yamajoni akho omzimba kwaye ikugcina usempilweni ngokulwa neentsholongwane. Kubandakanya i-lymph nodes, ii-lymph nodes kunye namalungu afana ne-spleen yakho, i-thymus kunye nabanye. I-B-cell lymphocytes yakho ihlala kakhulu kwinkqubo yakho ye-lymphatic.
Kwenzeka ntoni xa i-PCNSL ikhula?

I-PCNSL ikhula xa i-lymphocytes enomhlaza ifunyenwe kwinkqubo yakho ye-nervous central (CNS), equka ingqondo yakho, intambo yomgogodla, amehlo, i-cranial nerves kunye nokukhusela kwezicubu ezigubungela ingqondo yakho kunye nentambo yomgogodla ebizwa ngokuba yi-meninges.

Xa une-PCNSL, i-lymphocytes yakho yomhlaza:

  • Khula ngokungalawulekiyo
  • Ayiyi kusebenza ngokufanelekileyo ukulwa nosulelo kunye nezifo
  • Inokuba nkulu kunokuba ifanele kwaye inokujongeka yahlukile kwiiseli zakho ze-B ezisempilweni 
  • Inokubangela ukuba i-lymphoma ikhule kwingqondo yakho, intambo yomgogodla kunye namehlo.
  • Ngenxa yezithintelo ezikhuselayo ezijikeleze i-CNS yethu, i-PCNSL ayiqhelekanga ukusasazeka kwezinye iindawo zomzimba wakho njengezinye iintlobo ze-lymphoma, nangona kunjalo, ngamanye amaxesha ziyakwazi ukusasaza iimvavanyo kumadoda.

Iimpawu xa i-lymphoma ikwi-Central Nervous System (CNS)

Iimpawu ze-lymphoma kwi-CNS yakho zihambelana nemisebenzi yengqondo yakho, amehlo kunye nentambo yomgogodla. Ziya kuxhomekeka ekubeni yeyiphi inxalenye ye-CNS yakho echaphazelekayo kwaye inokubandakanya oku kulandelayo:

  • intloko
  • utshintsho kumbono wakho
  • ukubhideka okanye utshintsho kwimemori
  • utshintsho kwingqondo (ukozela nokungaphenduli)
  • kunzima ukuthetha okanye ukuginya
  • utshintsho kwimo yakho okanye ubuntu bakho
  • ukuxhuzula (ukulingana)
  • isicupunu kunye nokuhlanza
  • ukulahlekelwa ngumdla (ongafuni ukutya) kunye nokunciphisa umzimba
  • ubunzima bokuya kwindlu yangasese
  • ubunzima bokuhamba, ukungazinzi okanye ukuwa
  • ubuthathaka, ukuba ndindisholo okanye ukuntyiloza.

Ukuxilongwa, ukuhlelwa kunye nokuhlelwa kwe-PCNSL

Ukuba ugqirha wakho ukrokrela ukuba unokuba ne-lymphoma kuya kufuneka wenze iimvavanyo ezininzi. Ngokungafani nezinye ii-subtypes ze-lymphoma, i-staging ayenziwa ukuba unayo i-PCNSL kuba i-lymphoma ivalelwe kwinkqubo yakho ye-nervous central (CNS). Nakuphi na ukusasazeka ngaphandle kwe-CNS kudla ngokuba ngamadoda kuphela kwaye kuma testes kuphela. 

I-PCNSL ihlala ithathwa njenge-lymphoma ephezulu ethetha ukuba inobudlova. Ikhula ngokukhawuleza kwaye inokuhamba kwi-CNS yakho ngokukhawuleza. Iiseli ze-B ezinomhlaza (iiseli ze-lymphoma) nazo zikhangeleka zahluke kakhulu kwiiseli zakho ze-B ezisempilweni kuba zikhula ngokukhawuleza kwaye azinalo ixesha lokubumba ngokufanelekileyo.

Cofa kwisihloko esingezantsi ukuze ufunde ngakumbi malunga nohlobo lovavanyo onokuthi uluxilonge, kwaye ufunde ngakumbi malunga ne-PCNSL yakho.

Biopsy

Ukuxilonga i-PCNSL uya kufuna i-biopsy. I-biopsy yinkqubo yokususa inxalenye, okanye yonke i-lymph node echaphazelekayo okanye izicubu ezichaphazelekayo. Ngexesha lenkqubo unokufumana isibulali-zizolisi ngokubanzi okanye sasekhaya ukwenza ukuba ukhululeke ngakumbi, okanye uqinisekise ukuba awuvuki ngelixa isenziwa.

Uhlobo lwe-biopsy oluya kwenziwa luya kuxhomekeka apho i-lymphoma ikhoyo.

Ukuba i-lymphoma icingelwa ukuba ikuwe:

  • Ubuchopho - i-neurosurgeon (ingcali ekuxilongeni nasekuphatheni iingxaki nge-CNS) ithatha i-biopsy yobuchopho. Amaqhuma (okanye iisampuli zamaqhuma) ngaphakathi kwengqondo yakho ziya kususwa usebenzisa i-CT scan ukunceda ukukhokela inaliti ye-biopsy kwindawo efanelekileyo. Oku kubizwa ngokuba yi-a 'i-stereotactic biopsy'. Uya kuba ne-anesthetic jikelele kule nkqubo njengoko kubalulekile ukuba ungahambi.
  • Iliso - i-ophthalmologist (ingcali kwizifo kunye nokulimala kweso) inokuthatha i-vitreous encinci (i-gel-like substance ngaphakathi kweso lakho) ukujonga iiseli ze-lymphoma.
  • Umqolo - ingcali ngeradiologist inokuthatha i-biopsy kumqolo wakho.

Ukuhlolwa kwegazi

Uvavanyo lwegazi luyathathwa xa uzama ukuxilonga i-lymphoma yakho, kodwa nakulo lonke unyango ukuze ugqirha akwazi ukuqonda ngcono impilo yakho yonke, kwaye uqinisekise ukuba amalungu akho asebenza ngokufanelekileyo ukuhlangabezana nonyango.

Esi skena sikholisa ukunika eyona mifanekiso ilungileyo yobuchopho bakho kunye nezinye iindawo ze-CNS kwaye sinokubona ukuxinzezeleka komnqonqo.

MRI
MRI scan yobuchopho

Ezi zikhewu ziqhele ukwenziwa ukubona i-lymphoma kwenye indawo emzimbeni. Banika imifanekiso eneenkcukacha enika ulwazi ngakumbi kuneX-reyi eqhelekileyo. Zisenokwenziwa kwakhona ukujonga amathambo kumqolo wakho.

CT scan

Olu hlobo lokuskena luhlala lusetyenziswa ngokudibeneyo ne-CT scan ukubona i-lymphoma esebenzayo kwenye indawo emzimbeni wakho. Kuthatha umfanekiso wengaphakathi lomzimba wakho wonke. Uya kunikwa inaliti eneyeza elithile elifunxa iiseli ezinomhlaza ezinjengeeseli ze-lymphoma. Iyeza linceda i-PET scan ukuba ibone ukuba iphi i-lymphoma kunye nobukhulu kunye nokumila ngokugqamisa iindawo ezineeseli ze-lymphoma. Ezi ngamanye amaxesha zibizwa ngokuba "zishushu".  

Njengoko i-PCNSL inokuchaphazela amehlo unokufuna iimvavanyo ezahlukeneyo ze-ophthalmic. I-ophthalmologist (ingcali yamehlo) iya kusebenzisa i-ophthalmoscope - isixhobo esinokukhanya kunye nelensi encinci yokukhulisa - ukujonga kakuhle ngaphakathi kweso lakho. Iimvavanyo ezithile zokucinga zinokwenziwa kwaye ezi zinceda i-ophthalmologist ijonge ithumba kwaye ibone ukuba umhlaza usasazekile na.

 

I-biopsy yeliso inokufuneka. Oku kubizwa ngokuba yi-vitrectomy. Isixhobo esincinci sifakwa esweni kwaye sithatha iisampulu ze-jelly-like vitreous, nto leyo ezalise umbindi weliso.

I-testicular ultrasound yamadoda luvavanyo olufumana imifanekiso yamasende kunye nezicubu ezijikelezileyo kwi-scrotum. Le ultrasound inokuqhutywa njengoko i-PCNSL ethile inokusasazeka kwiimvavanyo.

iziphumo

Ukulinda ukuba zonke iziphumo zakho zingene kunokuba lixesha elinzima kakhulu kuwe kunye nabo ubathandayo. Kubalulekile ukuthetha ngendlela oziva ngayo kwaye ukhululeke kwabo bakungqongileyo malunga nento oyifunayo. Abantu abaninzi bafuna ukunceda, kodwa abazi ukuba njani ngoko ngokubazisa into oyifunayo, unokubanceda bakunike inkxaso oyifunayo.

Kusenokukunceda ukuqalisa ukucwangcisa oko unokukufuna kwiinyanga ezizayo ukuba ufuna unyango. Sibeke iingcebiso kunye kwiLiving with Lymphoma-Iphepha lewebhu lezinto eziSebenzayo. Cofa kwikhonkco elingezantsi ukuze uqondiswe kwelo phepha.

Ungaqhakamshelana nomnxeba wethu woNcedo woMongikazi ukuba uthethe nomnye wabongikazi bethu boNonophelo lweLymphoma. Cofa nje kwi Qhagamshelana nathi iqhosha ezantsi kweli phepha.

Ungaphinda uthande ukujoyina elinye lamaphepha ethu onxibelelwano ukuze uncokole nabanye abantu abahlala nabo. Qhagamshelana namaphepha ethu eendaba zoluntu ngokucofa amakhonkco aphezulu ephepha.

Ukuze uthole ulwazi oluthe xaxa bonani
Ukuhlala neLymphoma-Izinto eziSebenzayo

Unyango lwe-PCNSL

Ukuba nolwazi olululo kunokukunceda uzive uzithembile kwaye wazi omawukulindele, kwaye kunokukunceda ukucwangcisa kwangaphambili oko unokukufuna. Kodwa kunokuba nzima ukwazi ukuba yeyiphi imibuzo omawuyibuze xa uqala unyango. Ukuba awuyazi, into ongayaziyo, ungazi njani into omawuyibuze?

Sihlanganise uluhlu lwemibuzo onokuyifumana iluncedo. Kambe ke, imeko yomntu wonke yahlukile, ngoko le mibuzo ayiquki yonke into, kodwa inika isiqalo esihle. Cofa kwikhonkco elingezantsi ukufumana ikopi yePDF onokuthi uyikhuphele kwaye uyiprinte ukuba uyathanda.

Cofa apha ukukhuphela Imibuzo onokuyibuza ugqirha wakho phambi kokuba uqale unyango.

Ukugcinwa kokuchuma

Nokuba uyindoda okanye ungowasetyhini, unyango oluninzi oluchasene nomhlaza lunokuchaphazela ukuchuma kwakho - ukukwazi kwakho ukwenza abantwana. Ukuba ungathanda ukuba neentsana emva konyango, okanye awuqinisekanga ukuba uya kwenza na, thetha nogqirha wakho malunga nokuba zeziphi iindlela ezikhoyo zokukhusela ukuzala kwakho ngexesha lonyango.

Isishwankathelo seentlobo zonyango

Cofa kwizilayidi ezingezantsi ukuze ufumane isishwankathelo seentlobo ezahlukeneyo zonyango onokuthi unikwe ukunyanga i-PCNSL yakho.

Unyango lweSteroid
Uya kuqaliswa kwi-steroids emva kokuba wenze i-biopsies yakho. I-Steroids inceda ukunciphisa ukudumba kwindawo ye-lymphoma kwaye inokunceda ukuphucula iimpawu zakho. Ngokuqhelekileyo ziqalwa emva kwe-biopsies kuba i-lymphoma ingaba nzima ukuxilonga ukuba i-steroids sele inikezelwe.

Nangona kunjalo, ukuba uneempawu ezinzima kwaye ugqirha wakho uqinisekile ukuba unayo i-PCNSL, banokukhetha ukuqala i-steroids ukuphucula iimpawu zakho nangaphambi kwe-biopsy yakho.

Iisteroids zikwayityhefu kwiiseli ze-lymphoma ukuze zincede ukucutha i-lymphoma ngelixa ulinde olunye unyango ukuba luqale.

Iisteroids zinokunikwa ngemithambo (ngomthambo) okanye ngomlomo (ngomlomo). I-steroid eqhelekileyo yi-dexamethasone.
Ikhemotherapy (ikhemo)
Ungawafumana la mayeza njengepilisi kwaye/okanye unikwe njengethontsi (ukufakwa) kumthambo wakho (kwigazi lakho) kwikliniki yomhlaza okanye esibhedlele. I-Chemo ibulala iiseli ezikhula ngokukhawuleza ngoko iyasebenza ngokuchasene ne-lymphomas enobudlova, kodwa inokuchaphazela ezinye zeeseli zakho ezilungileyo ezikhula ngokukhawuleza, ezibangela iziphumo ebezingalindelekanga ezingafunekiyo.

I-chemo oyifumanayo ye-PCNSL inokwahluka kubantu abanezinye ii-subtypes ze-lymphoma, njengoko amayeza kufuneka awele umqobo wakho wegazi-ubuchopho ukuze ufike kwi-lymphoma yakho. Kuqhelekile ukuba nechemotherapy kunye ne-immunotherapy efana ne-rituximab.
Umzimba womntu ongena emzimbeni
Ii-antibodies ze-Monoclonal ngamanye amaxesha zibizwa ngokuba yi-immunotherapy kuba zinceda amajoni akho omzimba aqaphele kwaye alwe ne-lymphoma.

Unokuba ne-MAB yokufakelwa kwiklinikhi yomhlaza okanye esibhedlele. Ii-MABs zincamathela kwiseli ye-lymphoma kwaye zitsala ezinye izifo-ezilwa neeseli ezimhlophe zegazi kunye neeprotheni kumhlaza ukuze isistim somzimba sakho silwe ne-PCNSL.
Unyango lwe-radiation
Iradiationtherapy isebenzisa i-radiation ukubulala iiseli zomhlaza. Kufana neeX-reyi zamandla aphezulu kwaye zenziwa yonke imihla, ngokuqhelekileyo ukusuka ngoMvulo ukuya ngoLwesihlanu iiveki ezininzi.

I-radiotherapy yobuchopho obupheleleyo idla ngokusetyenziswa njengonyango lokudibanisa emva kwechemotherapy.

Kuze kube phakathi kwe-nineties yayiyeyona ndlela yonyango ye-PCNSL, nangona kunjalo ngoku inikezelwa ngokudibanisa ne-chemotherapy. Unyango lokudibanisa lujolise ekunciphiseni umngcipheko wokuphinda ubuyele (i-lymphoma iyabuya). I-Radiotherapy ingasetyenziselwa ngokwayo ukuba awukwazi ukunyamezela i-chemotherapy.
Ukufakelwa kweseli
Ukuba usemncinci kwaye une-lymphoma enobudlova, i-SCT inokucetyiswa njengonyango, nangona olu nyango alufanelekanga kumntu wonke.

I-SCT iyenziwa ukutshintsha umongo wakho onesifo iiseli ezitsha ezinokukhula zibe ziiseli zegazi ezisempilweni. Nge-SCT, iiseli ze-stem ziyasuswa egazini. Iiseli ze-stem zingasuswa kumnikeli okanye ziqokelelwe kuwe emva kokuba une-chemotherapy.

Ukuba iiseli ze-stem zivela kumnikeli, kuthiwa yi-allogeneic stem cell transplant. Ukuba iiseli zakho ze-stem ziqokelelwa, ibizwa ngokuba yi-autologous stem cell transplant.
Isilayidi esedlule
Isilayidi esilandelayo

Unyango lodidi lokuqala

Kuya kufuneka uqalise unyango kwakamsinyane emva kokuba zonke iziphumo zovavanyo zibuyile. Kwezinye iimeko, unokuqalisa phambi kokuba zonke iziphumo zovavanyo zingene. Isenokubanzima kakhulu xa uqala unyango. Unokuba neengcinga ezininzi malunga nendlela oza kumelana ngayo, indlela yokulawula ekhaya, okanye indlela ogula ngayo.

Yazisa iqela lakho lonyango ukuba uvakalelwa kukuba ufuna inkxaso eyongezelelweyo. Basenokukwazi ukukunceda ngokukuthumela ukuba ubone unontlalontle okanye enye ingcali yezempilo ukuze ikuncede ujongane nemiceli mngeni yokuphila yemihla ngemihla. Unako kwakhona ukufikelela kwi Lymphoma Care Nurses ngokucofa kwi "Qhagamshelana nathi" iqhosha ezantsi kweli phepha.

Xa uqala unyango okokuqala, lubizwa ngokuba 'lunyango lodidi lokuqala'. Unokuba namayeza angaphezu kwelinye, kwaye anokubandakanya unyango lweradiyo, ichemotherapy okanye i-monoclonal antibody.

Unyango olusemgangathweni lodidi lokuqala lungabandakanya:

 Idosi ephezulu yemethotrexate 

Oku kunokudityaniswa okanye ngaphandle kwe-antibody ye-monoclonal, i-rituximab.

 MATRix

Le yindibaniselwano yamayeza ahlukeneyo e-chemotherapy kunye ne-antibody ye-monoclonal - i-methotrexate, i-cytarabine, i-thiotepa kunye ne-rituximab - kwi-PCNSL esandula ukuxilongwa.

R-MPV (Icandelo lokuqala kunye neCandelo lesibini)

Inxalenye enye - i-antibody ye-Monoclonal (rituximab) kunye nokudibanisa i-chemotherapy kuquka i-methotrexate, i-procarbazine kunye ne-vincristine.

Icandelo lesibini - i-chemotherapy ephezulu-i-cytarabine

I-Methotrexate kunye ne-cytarabine

Indibaniselwano yeekhemotherapies ezimbini ze-PCNSL esandula ukuxilongwa.

Unyango lwe-chemotherapy

Le yichemotherapy enikwa kulwelo lomqolo ngendlela yokugqabhuka kwelumbar. Oku kwenziwa ukuba i-lymphoma ifunyenwe kwi-spinal fluid yakho.

Ukuthatha inxaxheba kulingo lwezonyango

Oku kunokubandakanya ulingo lwezonyango olujoliswe kunyango kunye nolunye unyango. Buza ugqirha wakho ukuba ufanelekile na kulo naluphi na ulingo lonyango lokuqala lonyango.

I-Radiotherapy okanye iStem Cell Transplant

Ukuba i-lymphoma isabela kwi-chemotherapy, iqela lakho lezonyango lingacebisa i-radiotherapy yobuchopho obupheleleyo okanye i- i-autologous stem cell transplant (jonga ngasentla). Olu lunyango lokudibanisa, okuthetha ukuba lusetyenziselwa ukunciphisa umngcipheko wokuphinda ubuyele emva konyango oluyimpumelelo.

Umgca wesibini kunye nonyango oluqhubekayo

Ukuba i-CNS lymphoma yakho iphinda ibuyele (ibuya) okanye i-refractory (ayiphenduli) kunyango, kunokubakho olunye unyango olukhoyo.

Unyango onalo ukuba uyaphinda okanye une-PCNSL ephikisayo ibizwa ngokuba lunyango lodidi lwesibini. Unyango luxhomekeke ekubeni ulunge kangakanani na ngelo xesha, loluphi unyango osele unalo kunye nendlela i-lymphoma ekuchaphazela ngayo. Ingcali yakho inokuthetha nawe ngokhetho lwakho, olunokubandakanya:

  • Ichemotherapy eqatha ngakumbi (eyomelele), ekunokwenzeka ukuba ilandelwe yi-autologous stem cell transplant (engabafanelanga abanye abantu).
  • IRadiotherapy – ukuba ayikanikezelwa.
  • Unyango lokuthomalalisa olunikezelwa ngenjongo yokuthomalalisa iimpawu.
  • Ukuthatha inxaxheba kulingo lwezonyango.

Uvavanyo lweZliniki

Kucetyiswa ukuba nangaliphi na ixesha kufuneka uqalise unyango olutsha ubuze ugqirha wakho malunga nolingo lwezonyango onokuthi ulufanelekele.

Ulingo lwezonyango yindlela ebalulekileyo yokufumana amayeza amatsha, okanye indibaniselwano yamayeza ukuphucula unyango lwe-PCNSL kwixesha elizayo. Basenokukunika ithuba lokuzama iyeza elitsha, indibaniselwano yamayeza okanye olunye unyango ongenakukwazi ukulufumana ngaphandle kolingo. Ukuba unomdla wokuthatha inxaxheba kulingo lwezonyango, buza ugqirha wakho ukuba loluphi ulingo lwezonyango olufanelekileyo. 

Kukho unyango oluninzi kunye neendibaniselwano zonyango olutsha oluvavanywayo ngoku kulingo lwezonyango kwihlabathi jikelele kubantu abane-PCNSL esandula ukuxilongwa kunye ne-relapsing/refractory PCNSL. Olunye unyango oluphantsi kophando lu:

  • Ibrutinib (Imbruvica®)
  • Zanubrutinib (Brukinsa®) kunye neTiselizumab
  • I-Pembrolizumab (Keytruda®)
  • I-GB5121 - i-Brain engena kwi-BTK inhibitor
Ukuze uthole ulwazi oluthe xaxa bonani
Iziphumo ebezingalindelekanga zonyango

Ukuqonda izilingo zeklinikhi

Uqikelelo lwe-PCNSL

I-prognosis ligama elisetyenziselwa ukuchaza indlela enokwenzeka yesifo sakho, ukuba siya kusabela njani kunyango kunye nendlela oya kwenza ngayo ngexesha nasemva konyango.

Kukho izinto ezininzi ezinegalelo kwi-prognosis yakho kwaye akunakwenzeka ukunika ingxelo malunga ne-prognosis.

Izinto ezinokuchaphazela i-prognosis

 Ezinye izinto ezinokuchaphazela i-prognosis yakho ziquka:

  • Ubudala bakho kunye nempilo yonke ngexesha lokuxilongwa
  • Indlela ophendula ngayo kunyango

Ngamanye amaxesha iimpawu ze-CNS lymphoma zixazulula ngokukhawuleza ngonyango. Unyango lokuqala nge-steroids lunokusebenza kakhulu ekudambiseni iimpawu. Nangona kunjalo, izicubu zemithambo-luvo zikhula ngokucothayo, kwaye ngamanye amaxesha kunokuthatha ixesha ukuba iimpawu ziphucuke. Abanye benu banokubona ukuphucuka kancinci kweempawu, nangona kunjalo, banokufumana iimpawu ezinokuthi zingasombululi ngokupheleleyo, ngakumbi ukuba bezikhona phambi konyango.

Ukufumana inkxaso

Iqela lakho lonyango linokuxhasa ukuchacha kwakho ngokukuthumela kwiingcali ezifanelekileyo. Ukuba ufumana ubuthathaka bemisipha kunye nokuncipha kwamandla okanye awululali ngokukhawuleza, kufuneka ucinge ngokubona i-physiotherapist kunye / okanye i-occupational therapist njengoko inokunika uncedo kunye neengcebiso zokuphucula umgangatho wobomi. Uncedo lwabo lunokunqanda iimpawu ukuba zibe mandundu okanye ezinye iingxaki ezivela kwixesha elide.

Iingcali zengqondo zinokunika inkxaso ukuba kukho iingxaki zengqondo (yokucinga), ezifana neengxaki zememori okanye ingqalelo. Iingcali zengqondo kunye nabacebisi banokuxhasa ngefuthe leemvakalelo ze-lymphoma yakho.

Kubalulekile ukuba uqaphele ukuba izicwangciso zonyango ze-PCNSL ziphuculwe kakhulu kwiminyaka yamuva. Nangona kunjalo, i-PCNSL inokuba nzima ukuyiphatha, kwaye ezinye iindlela zonyango zinomngcipheko wokubangela iingxaki ze-neurological zexesha elide (iingxaki zengqondo kunye namehlo). Ezi ngxaki ziba lula ukuba ufunyaniswe une-CNS lymphoma xa umdala.  

 

Ukusinda - Ukuphila kunye, kwaye emva komhlaza

Indlela yokuphila esempilweni, okanye utshintsho oluthile lwendlela yokuphila entle emva konyango lunokuba luncedo olukhulu ekuchacheni kwakho. Zininzi izinto onokuzenza ukukunceda ukuba uphile kakuhle emva kukaBurkitt. 

Abantu abaninzi bafumanisa ukuba emva kokuxilongwa komhlaza, okanye unyango, ukuba iinjongo zabo kunye nezinto eziphambili ebomini ziyatshintsha. Ukwazi ukuba yintoni 'yesiqhelo sakho esitsha' kunokuthatha ixesha kwaye kuyakukhathaza. Ulindelo losapho lwakho nezihlobo lunokwahluka kolwakho. Unokuziva ulilolo, udiniwe okanye naliphi na inani leemvakalelo ezahlukeneyo ezinokutshintsha suku ngalunye.

Iinjongo eziphambili emva kwonyango lwe-lymphoma yakho kukubuyela ebomini kwaye:            

  • khuthala kangangoko unako emsebenzini wakho, kusapho, nakwezinye iindima zobomi
  • ukunciphisa iziphumo ebezingalindelekanga kunye neempawu zomhlaza kunye nonyango lwawo      
  • chonga kwaye ulawule naziphi na iziphumo ebezingalindelekanga emva kwexesha      
  • kukunceda uhlale uzimele kangangoko
  • phucula umgangatho wobomi bakho kwaye ugcine impilo entle yengqondo

Iindidi ezahlukeneyo zokubuyisela umhlaza zingacetyiswa kuwe. Oku kungathetha naluphi na uluhlu olubanzi weenkonzo ezifana:     

  • unyango lomzimba, ulawulo lweentlungu      
  • isicwangciso sesondlo kunye nokuzilolonga      
  • ingcebiso ngokweemvakalelo, ngomsebenzi nangemali. 

isishwankathelo

  • I-Primary Central Nervous System Lymphoma (PCNSL) i-high-grade aggressive subtype ye-Non-Hodgkin Lymphoma ephuhliswa kwinkqubo yakho ye-nervous central (CNS).
  • I-PCNSL ayiqhelekanga ukusasazeka ngaphandle kwe-CNS kodwa inokusasazeka kumastestes emadodeni.
  • I-PCNSL ihluke kwi-lymphomas eqala kwenye indawo emzimbeni kwaye isasazeka kwi-CNS (i-CNS yesibili lymphoma) kwaye kufuneka iphathwe ngokuhlukileyo.
  • Iimpawu ze-PCNSL zihambelana nendawo ye-lymphoma, kubandakanywa iimpawu ezinxulumene nemisebenzi yengqondo yakho, intambo yomgogodla kunye namehlo.
  • Kukho iintlobo ngeentlobo zovavanyo oza kuzifuna ukufumanisa i-PCNSL, kwaye ezi zinokubandakanya iinkqubo apho unikwe isithomalalisi ngokubanzi okanye sasekhaya.
  • Unyango lwe-PCNSL lwahlukile kwezinye ii-subtypes ze-lymphoma njengoko amayeza kufuneka adlule kwisithintelo segazi-ingqondo ukuya kwi-lymphoma.
  • Iimpawu zinokuthatha ixesha elithile ukuba ziphucuke emva konyango ngenxa yokukhula kancinci kweeseli zemithambo-luvo, kodwa ezinye iimpawu zinokuphucuka ngokukhawuleza.
  • Thetha nogqirha wakho malunga namathuba onyango kunye nokuba ulindele ntoni kunyango lwakho.
  • AWUKHO wedwa. Ukuba ungathanda ukuthetha nomnye wabongikazi bethu boNonophelo lweLymphoma malunga ne-lymphoma yakho, unyango kunye neenketho cofa iqhosha Qhagamshelana nathi ezantsi kwesikrini.

Inkxaso kunye nolwazi

Funda ngakumbi malunga novavanyo lwegazi lakho apha - Iimvavanyo zaseLab kwi-intanethi

Funda ngakumbi malunga nonyango lwakho apha - eviQ unyango lwe-anticancer-Lymphoma

Bhalisela incwadana yeendaba

Yabelana Lo
inqwelana

Ileta yeendaba Bhalisa

Qhagamshelana neLymphoma Australia Today!

Nceda uqaphele: Abasebenzi baseLymphoma Australia bayakwazi ukuphendula kuphela ii-imeyile ezithunyelwe ngolwimi lwesiNgesi.

Kubantu abahlala eOstreliya, sinokubonelela ngenkonzo yokuguqulela ngeefowuni. Cela umongikazi wakho okanye isizalwane sakho esithetha isiNgesi asitsalele ukuba silungiselele oku.