Uhlolojikelele lwe-Transformed Lymphoma (TL)
I-lymphoma eguquliwe yenzeka lapho i-indolent lymphoma yakho ishintsha, futhi iba i-lymphoma enolaka enezici ze-subtype ehlukile ye-lymphoma. Lokhu kuhlukile ku-indolent lymphoma yakho "ukuvuka" noma ukusebenza kakhulu futhi udinga ukwelashwa. Kwezinye izimo, ungase ube namaseli e-lymphoma angenalutho futhi anonya njengoba i-lymphoma ihamba ngenqubo yokuguqula.
I-Indolent lymphomas ngokuvamile yenziwe ngamaseli amancane, akhula kancane. Kodwa-ke, uma amaningi alawa maseli eqala ukukhula, futhi ngokushesha, i-lymphoma iqala ukwenza njenge-lymphoma enolaka njenge-Diffuse Large B-cell Lymphoma (DLBCL). Akuvamile uma une-lymphoma eguquliwe, ukuba namaseli e-lymphoma axubile, amanye angamavila kanti amanye anolaka.
Izinhloso zokwelashwa kwe-lymphoma yakho engasebenzi noma eguquliwe
Ama-lymphomas amaningi angenalutho azohamba ngezigaba lapho elala futhi evuka. Kodwa-ke, uma i-lymphoma yakho engasebenzi iqala ukusebenza kakhulu futhi idinga ukwelashwa, uzoba nokwelashwa okuqondiswe ekulawuleni i-lymphoma yakho engasebenzi.
Nokho, uma i-indolent lymphoma yakho uyashintsha ube yi-subtype enolaka ye-lymphoma, cishe uzoba nokwelashwa okuqondiswe ekwelapheni, noma ukubeka i-lymphoma enolaka ekuxolelweni.
Kungani uguquko lwenzeka?
I-Lymphoma ingashintsha lapho amangqamuzana e-lymphoma, noma izakhi zofuzo ezinikeza imiyalelo kumaseli akho zithuthukisa ukuguqulwa kofuzo okusha. Lezi zinguquko ezintsha zingaba umphumela wokwelashwa kwangaphambilini okulwa nomdlavuza, noma kungenzeka ngaphandle kwesizathu esaziwayo. Izinguquko zofuzo zingashintsha indlela i-lymphoma ekhula ngayo futhi iziphathe ngayo, okuholela esimweni esinobudlova.
Ngubani othintwa yi-Transformed Lymphoma?
Noma ubani one-low-grade lymphoma noma i-indolent lymphoma usengozini yokuguqulwa. Nokho kuyivelakancane kakhulu, futhi kwenzeka kuphela kubantu abangaba ngu-1 kuya kwaba-3 kwabayi-100 abane-lymphoma engenzi lutho unyaka ngamunye (1-3%).
Uzoba sengozini ephakeme kancane yoshintsho uma unayo isifo esinzima (isimila esikhulu noma izimila) lapho uqala ukutholakala ukuthi une-lymphoma engasebenzi.
Ama-lymphomas ajwayelekile kakhulu angaguquka afaka i-B-cell lymphoma efana nalokhu:
- I-Follicular Lymphoma
- I-Chronic Lymphocytic Leukemia noma i-Small Cell Lymphoma
- I-Marginal Zone Lymphoma
- I-Nodular Lymphocyte Predominant B-cell Lymphoma (ngaphambilini eyayibizwa ngokuthi i-Nodular Lymphocyte Predominant Hodgkin Lymphoma)
- I-Mantle Cell Lymphoma evilaphayo
- I-Macroglobulinemia kaWaldenstrom
Kubalulekile ukuqonda ukuthi abantu abaningi abanalawa ma-lymphomas abaguquki.
Abanye abantu abane-T-cell lymphoma engenzi lutho bangase babe noshintsho, kodwa lezi zingavamile nakakhulu.
Kunini lapho uguquko okungenzeka lwenzeka khona kakhulu?
I-lymphoma eguquliwe ingenzeka nganoma yisiphi isikhathi, kodwa kungenzeka ukuthi ube noshintsho cishe eminyakeni emi-3-6 ngemuva kokutholakala ukuthi une-lymphoma yakho engasebenzi.
Ingozi yoguquko iyancipha kakhulu ngemva kokuphila ne-lymphoma yakho eyi-indolent iminyaka engu-15, uguquko ngemva kwalesi sikhathi luyivelakancane kakhulu.
Izimpawu lokho kungase kubonise ukuthi i-lymphoma yakho ishintshile
Ungathola futhi izimpawu ze-B njengoba i-lymphoma yakho iqala ukusebenza noma iqala ukuguquka
Yiziphi izinguquko ezivame kakhulu?
Ezinye izinguquko zivame kakhulu kunezinye. Ngezansi sibala izinguquko ezivame kakhulu (yize zisangavamile) ezingenzeka.
I-lymphoma engapheli |
Ingashintsha ibe yi-lymphoma elandelayo |
| I-Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) |
Uguquko Ukusabalalisa I-Large B-cell Lymphoma (DLBCL) - lolu shintsho lubizwa nge-Richter syndrome. Okungavamile kakhulu, i-CLL/SLL ingashintsha ibe uhlobo oluncane lwe-Hodgkin Lymphoma. |
| I-Follicular Lymphoma |
Uguquko oluvame kakhulu ukusabalalisa i-Large B-cell Lymphoma (DLBCL). Kuyaqabukela, ingashintsha ibe i-B-cell lymphoma enolaka, enezici zakho zombili i-DLBCL kanye ne-Burkitt Lymphoma. |
| I-Lymphoplasmacytic Lymphoma (ebizwa nangokuthi i-Waldenstrom's macroglobulinemia) | Ukusabalalisa I-Large B-cell Lymphoma (DLBCL). |
| I-Mantle Cell Lymphoma (MCL) | I-Blastic (noma i-blastoid) MCL. |
| I-Marginal Zone Lymphomas (MZL) | Ukusabalalisa I-Large B-cell Lymphoma (DLBCL). |
| I-Mucosa-Associated Lymphoid Tissue Lymphoma (MALT), uhlobo oluncane lwe-MZL | Ukusabalalisa I-Large B-cell Lymphoma (DLBCL). |
| I-Nodular Lymphocyte-Predominant B-cell Lymphoma (phambilini ebibizwa ngokuthi i-Nodular Lymphocyte-Predominant Hodgkin lymphoma) | Sabalalisa I-B-cell Lmphoma Enkulu (DLBCL). |
| I-Cutaneous T-cell Lymphoma (CTCL) | I-Lymphoma Yeseli Enkulu. |
Ukuxilongwa kanye nesiteji se-Lymphoma eguquliwe
Uma udokotela wakho esola ukuthi i-lymphoma yakho ishintshile uzofuna ukwenza izivivinyo eziningi namaskeni. Ukuhlola kuzobandakanya ama-biopsies ukuhlola ukuthi amangqamuzana e-lymphoma asethuthukile yini izinguquko ezintsha, futhi uma manje eziphatha njengohlobo oluhlukile lwe-lymphoma, futhi izikena kuzoba ukufaka i-lymphoma.
Lezi zivivinyo nezikena zizofana nalezo owawunazo ngesikhathi uthola ukuthi une-lymphoma. Ulwazi oluvela kulokhu luzonikeza udokotela wakho ulwazi oludingekayo ukuze akunikeze uhlobo lokwelapha olungcono kakhulu lwe-lymphoma yakho eguquliwe.
Ukwelashwa
Uma yonke imiphumela yakho evela ku-biopsy kanye nezikena zesiteji isiqediwe, udokotela wakho uzoyibuyekeza ukuze akunqumele ukwelashwa okungcono kakhulu ongakuthola. Udokotela wakho angase futhi ahlangane nethimba labanye ochwepheshe ukuze baxoxe ngokwelashwa okungcono kakhulu futhi lokhu kubizwa ngokuthi a Ithimba le-multidisciplinary (MDT) umhlangano.
Udokotela wakho uzocabangela izici eziningi mayelana ne-lymphoma yakho kanye nempilo yakho jikelele ukuze anqume ukuthi, futhi yikuphi ukwelashwa okudingekayo. Ezinye zezinto abazozicabangela zihlanganisa:
- Iluphi ushintsho olwenzekile (i-subtype yakho entsha ye-lymphoma)
- Isigaba se-lymphoma
- Noma yiziphi izimpawu ozitholayo
- Indlela i-lymphoma ewuthinta ngayo umzimba wakho
- Iminyaka yakho
- Noma yiziphi ezinye izinkinga zezokwelapha onazo noma imithi oyiphuzayo
- Okuncamelayo uma usuthole lonke ulwazi oludingayo.
Izinhlobo Zokwelashwa
I-lymphoma eguquliwe idinga ukuphathwa ngendlela efanayo ne-lymphoma enolaka. Ukwelashwa kungabandakanya:
- I-chemotherapy ehlanganisiwe
- Igciwane lomzimba elilodwa
- Ukufakelwa kwe-stem cell kwe-Autologous (uma unempilo ngokwanele)
- Radiotherapy (ngokuvamile nge-chemotherapy)
- Ukwelashwa kwe-CAR T-cell (I-Chimeric antigen receptor T-cell therapy - ngemva kokwelapha oku-2 kwangaphambili)
- immunotherapy
- Izindlela zokwelapha ezihlosiwe
- Ukubamba iqhaza kokuhlolwa komtholampilo
I-Prognosis ye-Lymphoma eguquliwe (TL)
Ama-lymphomas amaningi anolaka angelapheka, noma abe nezikhathi ezinde zokuxolelwa ngemva kokwelashwa. Ngakho-ke, kunethemba lokuthi lapho unikezwa ukwelashwa ungase welapheke, noma uthole ukukhululeka okuhlala isikhathi eside ku-lymphoma enamandla kakhulu, eguquliwe. Nokho, usazodinga ukulandelelwa eduze ngemva kokwelashwa kwakho ukuze uhlole izimpawu zokuphinda ugule.
I-Indolent lymphomas ezimweni eziningi ayikwazi ukuphulukiswa, ngakho-ke ngisho nangemva kokwelashwa kwe-lymphoma yakho eguquliwe, ungase ube namaseli e-lymphoma angenalutho asele, futhi ngaleyo ndlela udokotela wakho uzofuna ukukuhlola lokhu.
Buza udokotela wakho ukuthi yimaphi amathuba okuba welashwe, ungene ekuxolelweni futhi usahlala ne-indolent lymphoma ngemva kokwelashwa kwe-lymphoma yakho eguquliwe.
Isifinyezo
- I-lymphoma eguquliwe ayivamile kakhulu, cishe ngabantu abangu-1-3 kwabayi-100 abane-lymphoma engenzi lutho abanoguquko unyaka ngamunye.
- Ukuguqulwa kuvame kakhulu kubantu abane-B-cell lymphoma engenzi lutho, kodwa kungenzeka kubantu abane-T-cell lymphoma engenzi lutho.
- Ukuguqulwa kuvame kakhulu eminyakeni emi-3-6 ngemva kokutholakala ukuthi une-lymphoma engenzi lutho, futhi akuvamile kakhulu ngemva kweminyaka engu-15.
- I-Lymphoma eguquliwe ingenzeka uma izakhi zakho zofuzo noma amangqamuzana e-lymphoma enza izinguquko ezintsha, eshintsha indlela i-lymphoma ekhula ngayo futhi iziphathe ngayo.
- I-Lymphoma eguquliwe ihlukile kune-lymphoma engenzi lutho "evuka" futhi isebenze kakhulu.
- Kusenamandla okuphulukiswa ku-lymphoma eguquliwe kakhulu, kodwa ungase uqhubeke uhlala ne-lymphoma engenalutho ngemva kokwelashwa.
- Ukwelashwa kwe-lymphoma eguquliwe kuzoqondiswa ekwelapheni, noma ukubeka i-lymphoma enolaka ekuxolelweni.
- Bika konke okusha nokubi izimpawu, kuhlanganise B-izimpawu kudokotela wakho.
