He aha ka leukemia cell hairy?
ʻO ka maʻi maʻi maʻi lauoho lauoho (HCL) kahi ʻano maʻi leukemia mau loa o ka ʻōnaehana lymphoid. Kapa ʻia ʻo ia he 'leukemia' no ka mea hiki ke loaʻa i loko o ke koko a me ka ʻiʻo iwi (ka ʻiʻo spongy i waenakonu o nā iwi kahi i hana ʻia ai ke koko).
ʻO nā B-lymphocytes maʻamau e hōʻiliʻili i loko o ka iwi iwi, ate, a me ka spleen. Hoʻokaʻawale ʻia ʻo HCL ma ke ʻano he maʻi maʻi leukemia maʻamau, ʻo ia ka ulu mālie, pinepine i nā makahiki he nui.
ʻO ka HCL kahi ʻano maʻi maʻi leukemia a he 2% wale nō o nā maʻi leukemia āpau i ʻike ʻia.
ʻO nā lymphocytes B (ʻike pū ʻia ʻo B-cells) he mau ʻili koko keʻokeʻo kūikawā. Ma lalo o nā kūlana maʻamau, hana lākou i nā immunoglobulins (i kapa ʻia hoʻi nā antibodies) e kōkua i ka pale ʻana i ko mākou kino mai ka maʻi a me ka maʻi. I loko o ka poʻe me ka leukemia cell hairy, loaʻa nā lymphocytes i kahi hoʻololi ʻino (cancerous) a lilo i mau sela leukaemic.
Ma lalo o ka microscope, ʻike ʻia kēia mau cell i nā hiʻohiʻona liʻiliʻi e like me ka lauoho ma ko lākou ʻili, no laila ko lākou inoa ʻo "hairy cell".
ʻO wai ka mea i loaʻa i ka Hairy cell leukemia (HCL)?
ʻOi aku ka maʻamau o ka HCL i nā kāne ma mua o nā wahine a loaʻa pinepine i ka makahiki waena (ʻo ka makahiki waena o ka hoʻomaka ʻana he 50). ʻAʻole hiki ke loaʻa i nā keiki a he kakaikahi i nā ʻōpio.
He aha nā hōʻailona o ka leukemia cell hairy?
Ma muli o ka ulu mālie ʻana o ka HCL he nui nā kānaka ʻaʻohe hōʻailona. Lawe ʻia ka maʻi i ka wā o ka hoʻāʻo koko maʻamau.
Hiki i nā poʻe ʻē aʻe ke hele e ʻike i kā lākou GP no ka mea he mau hōʻailona pilikia o ko lākou maʻi. Hiki i nā hōʻailona hiki ke komo:
- Ka luhi mau
- Hoʻoponopono
- Maʻaleʻa
- Pokole hanu ke hooikaika kino
- ʻO nā maʻi maʻi pinepine a i ʻole ka hoʻōla lohi
- ʻEha a ʻeha paha ma lalo o nā iwi ʻaoʻao ma ka ʻaoʻao hema
- ʻO ka pehu ʻole o nā lymph nodes (glands) ma kou ʻāʻī, ma lalo o kou mau lima a i ʻole ma kou ʻāʻī.
Hiki ke ʻike ʻia kekahi o nā hōʻailona i hōʻike ʻia ma luna nei i nā maʻi ʻē aʻe. ʻAʻole loaʻa i ka maʻi leukemia ka hapa nui o ka poʻe me kēia mau hōʻailona. He mea nui e ʻike i kāu kauka inā loaʻa iā ʻoe kekahi mau hōʻailona maʻamau, a i ʻole nā hōʻailona e lōʻihi loa ma mua o ka mea i manaʻo ʻia.
ʻIke ʻia o ka maʻi maʻi maʻi lauoho lauoho (HCL)
Ke ʻike ʻoe i kāu kauka e pili ana i kekahi o kāu mau hōʻailona, e lawe paha lākou:
- He moʻolelo olakino piha, e nīnau ana i nā nīnau e pili ana i kou olakino maʻamau, nā maʻi a i ʻole nā ʻokiʻoki āu i loaʻa ai ma mua.
- Hāʻawi lākou iā ʻoe i kahi hoʻokolokolo kino piha
- E nānā i nā laʻana o kou koko a me ka iwi iwi.
Helu koko piha
ʻO ka hana mua i ka hōʻailona he hoʻāʻo koko maʻalahi i kapa ʻia he helu koko piha (FBC). Hoʻopili kēia i ka lawe ʻana i kahi laʻana o ke koko mai kahi vein ma kou lima e hoʻouna ʻia i ke keʻena hana no ka hoʻokolokolo ʻana. ʻO ka hapa nui o ka poʻe me ka HCL he haʻahaʻa ʻulaʻula a me ka helu platelet. ʻO ka nui o nā keʻokeʻo keʻokeʻo keʻokeʻo he mau ʻano leukaemic blast cell a ʻo ka loaʻa ʻana o kēia mau pūnaewele pahū e hōʻike ana iā ʻoe he HCL.
Nānā iwi iwi
Inā hōʻike nā hopena o kāu hoʻāʻo koko e loaʻa iā ʻoe ka HCL, pono paha kahi biopsy iwi iwi e kōkua i ka hōʻoia ʻana i ka maʻi. ʻO ka biopsy iwi iwi ka lawe ʻana i kahi laʻana o ka iwi iwi (maʻamau mai ke kua o ka iwi ʻūhā) a hoʻouna ʻia i ke keʻena hana no ka nānā ʻana ma lalo o ka microscope. Nānā ʻia ka laʻana o ka iwi iwi i loko o ke keʻena hana no ka hoʻoholo ʻana i ka helu a me ke ʻano o nā cell i loaʻa a me ka nui o ka hana haematopoiesis (hoʻoulu koko) e hana nei ma laila.
ʻO ka hoʻāʻo hou ʻana
Ke hana ʻia kahi hōʻailona o ka HCL, e nānā hou ʻia ke koko a me ka iwi iwi me nā hoʻokolohua kūikawā. Loaʻa kēia mau hoʻokolohua cytogenetic, immunophenotyping a me immunoglobulin (antibody). Hāʻawi kēia mau hoʻāʻo ʻana i ka ʻike hou aku e pili ana i ke ʻano pololei o ka maʻi i loaʻa iā ʻoe, ke ala kūpono o kou maʻi a me ke ala maikaʻi loa e mālama ai.
He manawa paʻakikī ke kali ʻana i nā hopena. Hiki ke kōkua ke kamaʻilio me kou ʻohana, nā hoaaloha, a i ʻole kahi kahu hānai kūikawā.
Ke hoʻonohonoho
ʻAʻohe ʻōnaehana hoʻonohonoho i ʻae ʻia no ka leukemia cell hairy cell.
Hoʻohana nā kauka i kāu hopena hoʻāʻo e nānā i ka lōʻihi o ka ulu ʻana o kāu leukemia. Kapa ʻia kēia ʻano hoʻokūkū. ʻO ka hapa nui o nā ʻano maʻi kanesa he pae helu, mai ka 1 a hiki i ka 4, akā ʻaʻole hoʻohana maoli ʻia kēia no ka leukemia cell hairy cell.
ʻO ka wānana o ka maʻi leukemia lauoho lauoho (HCL)
Maikaʻi loa ka manaʻo no ka maʻi leukemia cell hairy. ʻO ka hapa nui o ka poʻe me ka leukemia cell hairy he maʻamau ke ola. Hoʻomaʻamaʻa maʻamau ka maʻi i ke kala ʻana (ʻaʻohe hōʻike o ka leukemia cell hairy cell i kāu mau hoʻāʻo) a ʻo ke kala ʻana i nā makahiki he nui. Hiki ke ho'i hou ka ma'i ma'i ma'i huluhulu (ho'i mai) akā kokoke i nā po'e a pau i ho'i hou 'ia e mālama hou 'ia.
Lapaʻau no ka maʻi maʻi maʻi lauoho lauoho (HCL)
Ke pau nā hualoaʻa mai ka biopsy a me nā scan staging, e nānā ke kauka i kēia mau mea no ka hoʻoholo ʻana i ka lāʻau lapaʻau maikaʻi loa no ʻoe. Ma kekahi mau keʻena maʻi 'aʻai, e hui pū ke kauka me kahi hui o nā loea e kūkākūkā i ka lāʻau lapaʻau maikaʻi loa no ʻoe. Kapa ʻia kēia he hui hui multidisciplinary (MDT).
E noʻonoʻo ana kāu mau kauka i nā kumu he nui e pili ana i kou lymphoma a me ke olakino maʻamau e hoʻoholo ai i ka wā a me ka lāʻau e pono ai. Hoʻokumu ʻia kēia ma:
- ʻO ka pae a me ka pae o ka lymphoma
- Ōuli
- Lapaʻau mua
- ʻO ka makahiki, ka mōʻaukala olakino a me ke olakino maʻamau
- Ke ola kino a me ka noʻonoʻo o kēia manawa
- Kāu Mau koho Paʻamau
Hiki i nā lāʻau lapaʻau maʻamau no ka Hairy cell leukemia (HCL) ke komo:
- E nānā a kali
- Chemotherapy - Cladribine
- ʻO ka lāʻau lapaʻau - Rituximab a i ʻole Interferon
- Kāpena
- Ke komo ʻana i ka hoʻokolohua lapaʻau
Nā hopena maʻamau o ka lāʻau lapaʻau
Nui nā hopena ʻaoʻao o ka lāʻau lapaʻau, ʻo ia hoʻi no kēlā me kēia regimen lapaʻau. Na ke kauka lapaʻau a/a i ʻole kahu maʻi maʻi e wehewehe i kēia i ka mea maʻi ma mua o ka hoʻomaka ʻana i ka mālama ʻana.
No ka 'ike hou aku e pili ana i kekahi o na hopena 'ao'ao ma'amau a emi'ole, e like me nā ala e kōkua ai i ka ho'okele pono'ī i kēia mau mea e 'ike i ka pauku ma 'nā hopena ma'amau.
ʻO kekahi o nā hopena ʻaoʻao maʻamau ka:
- ʻO Neutropenia (ʻano haʻahaʻa o ke koko keʻokeʻo keʻokeʻo e kōkua ana i ke kaua ʻana i ka maʻi maʻi)
- ʻO ka Thrombocytopenia (nā platelets haʻahaʻa e kōkua ana i ka hoʻopaʻa ʻana a i ʻole ke koko)
- Anemia (nā ʻulaʻula haʻahaʻa e kōkua i ka hāʻawi ʻana i ka oxygen i kou kino)
- ʻO ka naʻi a me ka luaʻi
- Nā pilikia ʻōpū (constipation or diarrhea)
- 'Oloke (ka luhi a me ka nele o ka ikehu)
Pono ka hui lapaʻau, kauka, kahu maʻi maʻi a lāʻau lapaʻau paha, e hāʻawi i ka ʻike e pili ana i ka mālama ʻana, nā hopena ʻaoʻao maʻamau, nā hōʻailona e hōʻike a me ka mea e hoʻopili ai. Inā ʻaʻole, e ʻoluʻolu e nīnau i kēia mau nīnau ma mua o ka haʻalele ʻana i ke kikowaena maʻi maʻi.
Ka mālama ʻana no ka maʻi maʻi maʻi lauoho lauoho (HCL)
Ke hoʻopau ʻia ka mālama ʻana, e hoʻopaʻa ʻia ka nānā ʻana i ka maikaʻi o ka hana ʻana a inā he pane piha (CR a ʻaʻohe hōʻailona o ka lymphoma i koe) a i ʻole pane hapa (PR a i ʻole he lymphoma i kēia manawa), akā ua loaʻa. hoemi i ka nui.
Pono nā mea maʻi e hahai ʻia e ke kauka me nā koho maʻamau maʻamau, maʻamau i kēlā me kēia 3-6 mahina. He mea koʻikoʻi kēia mau koho i hiki i ka hui lapaʻau ke nānā i ka maikaʻi o ke ola ʻana o ka mea maʻi mai ka mālama ʻana. Makemake ka hui lapaʻau e ʻike i ka manaʻo o ka mea maʻi ma ke kino a me ka noʻonoʻo, a i:
- E nānā i ka pono o ka lāʻau lapaʻau
- E nānā i nā hopena ʻaoʻao mai ka mālama ʻana i ka manawa
- E nānā i nā hopena hope loa mai ka lāʻau lapaʻau
- E nānā i nā hōʻailona o ka hoʻi hou ʻana o ka lymphoma
Loaʻa paha i nā maʻi kahi hoʻokolokolo kino a me nā hoʻāʻo koko no kēia mau koho. Ma waho aʻe o ka manawa ma hope o ka mālama ʻana e nānā i ka hana ʻana o ka mālama ʻana, ʻaʻole i hana pinepine ʻia nā scans ke ʻole he kumu no lākou. No kekahi poʻe maʻi hiki ke emi pinepine i ka manawa.
Lapaʻau ma lalo o ka noiʻi ʻana no ka maʻi maʻi maʻi lauoho lauoho (HCL)
Nui nā lāʻau lapaʻau e hoʻāʻo ʻia nei i nā hoʻokolohua lapaʻau a puni ka honua no nā poʻe maʻi me ka lymphoma hou a me ka hoʻi hou ʻana.
ʻO nā lāʻau lapaʻau maʻamau e nānā ʻia nei:
- ʻO Vemurafenib
- Ibrutinib (Imbruvica)
- Moxetumomab (Lumoxiti)
Nā hopena lohi
I kekahi manawa hiki ke hoʻomau ʻia ka hopena ʻaoʻao mai ka lāʻau lapaʻau a hiki ke ulu i nā mahina a i ʻole mau makahiki ma hope o ka pau ʻana o ka mālama ʻana. Kapa ʻia kēia he hopena hope. No ka 'ike hou aku, e hele i ka pauku 'hopena hopena' e a'o hou e pili ana i kekahi o ka hopena mua a me ka hopena hope e hiki mai ana ma hope o ka mālama 'ana i ka lymphoma.
Hoʻopau Lapaʻau
ʻO ka hoʻopau ʻana i ka mālama ʻana he manawa paʻakikī ia no nā poʻe he nui, ʻoiai lākou e hoʻoponopono hou i ke ola ma hope o ka mālama ʻana. ʻAʻole hoʻomaka paha kekahi poʻe e ʻike i kekahi o kēia mau pilikia no nā pule a i ʻole mau mahina ma hope o ka pau ʻana o ka mālama ʻana i ka maʻi kanesa, no ka mea, hoʻomaka lākou e noʻonoʻo i ko lākou ʻike a ʻaʻole manaʻo e hoʻi koke lākou e like me ka mea e pono ai. Hiki ke pili i kekahi o nā pilikia maʻamau i:
- Helu
- ʻO ke ʻano noʻonoʻo
- Ola kino
- 'ana ma
- Hana, aʻo, a me nā hana kaiaulu
No ka ʻike hou aku, a me nā ala e kōkua ai iā ʻoe e hoʻoponopono hou ma hope o ka mālama ʻana i ka lymphoma, e ʻoluʻolu e kipa i ka ʻāpana 'finishing treatment'.
ʻO ke olakino a me ke olakino
ʻO ke ola olakino, a i ʻole kekahi mau loli ola maikaʻi ma hope o ka mālama ʻana he mea kōkua nui ia ma hope o ka pau ʻana o ka mālama ʻana. ʻO ka hana ʻana i nā hoʻololi liʻiliʻi e like me ka ʻai ʻana a me ka hoʻonui ʻana i ke olakino hiki ke hoʻomaikaʻi i ke olakino a me ka maikaʻi a kōkua i ke kino e ola hou. He nui nā hoʻolālā mālama ponoʻī hiki ke kōkua i ka wā ho'ōla.
