Txheej txheem cej luam ntawm Transformed Lymphoma (TL)
Transformed lymphoma tshwm sim thaum koj cov qog ntshav qog ntshav tsis txaus hloov, thiab dhau los ua cov qog ntshav qog ntshav nrog cov yam ntxwv ntawm lwm hom qog ntshav qog ntshav. Qhov no txawv rau koj qhov mob qog nqaij hlav hauv plab "tsim" lossis ua kom nquag plias thiab xav tau kev kho mob. Qee qhov xwm txheej, koj tuaj yeem muaj ob qho tib si ua tsis taus thiab txhoj puab heev lymphoma hlwb raws li lymphoma mus los ntawm kev hloov pauv.
Indolent lymphomas feem ntau yog ua los ntawm cov hlwb me me, qeeb zuj zus. Txawm li cas los xij, yog tias muaj ntau lub hlwb pib loj dua, thiab sai sai, lymphoma pib ua zoo li cov qog ntshav qog ntshav xws li Diffuse Loj B-cell Lymphoma (DLBCL). Nws tsis yog qhov tsis tshua muaj tshwm sim thaum koj muaj cov qog ntshav qog ntshav hloov pauv, muaj cov qog ntshav qog ntshav sib xyaw, qee qhov ua tsis taus pa thiab lwm yam mob hnyav.
Lub hom phiaj ntawm kev kho mob rau koj lub cev tsis muaj zog lossis hloov pauv lymphoma
Feem ntau indolent lymphomas yuav dhau mus rau theem uas lawv tsaug zog thiab sawv. Txawm li cas los xij, yog tias koj qhov mob qog nqaij hlav tsis muaj zog ua kom nquag plias thiab xav tau kev kho mob, koj yuav tau txais kev kho mob los tswj koj cov qog ntshav qog ntshav tsis txaus.
Txawm li cas los xij, yog tias koj lub cev tsis muaj zog lymphoma hloov mus rau hauv ib qho kev txhoj puab heev ntawm lymphoma, koj yuav muaj peev xwm muaj kev kho mob ntawm kev kho, lossis muab cov qog nqaij hlav aggressive rau hauv kev zam.
Vim li cas kev hloov pauv tshwm sim?
Lymphoma tuaj yeem hloov pauv thaum cov qog ntshav qog ntshav, lossis cov noob uas muab cov lus qhia rau koj lub hlwb tsim cov kev hloov caj ces tshiab. Cov kev hloov pauv tshiab no tuaj yeem tshwm sim los ntawm kev kho mob qog noj ntshav yav dhau los, lossis tuaj yeem tshwm sim yam tsis paub qhov laj thawj. Cov kev hloov caj ces tuaj yeem hloov txoj kev lymphoma tsim thiab coj tus cwj pwm, ua rau muaj kev txhoj puab heev.
Leej twg raug cuam tshuam los ntawm Transformed Lymphoma?
Txhua tus neeg uas muaj cov qog ntshav qog ntshav qis lossis cov qog ntshav qog ntshav tsis txaus yog qhov pheej hmoo ntawm kev hloov pauv. Txawm li cas los xij, nws tsis tshua muaj, thiab tsuas yog tshwm sim hauv kwv yees li 1 mus rau 3 tus neeg hauv txhua 100 tus neeg mob qog nqaij hlav hauv lub xyoo (1-3%).
Koj yuav muaj kev pheej hmoo siab me ntsis ntawm kev hloov pauv yog tias koj muaj kab mob loj (cov qog loj lossis qog) thaum koj thawj zaug kuaj pom koj tus mob qog nqaij hlav hauv siab.
Feem ntau cov lymphomas uas tuaj yeem hloov pauv muaj xws li B-cell lymphoma xws li:
- Tshwj Xeeb Lymphoma
- Chronic Lymphocytic Leukemia lossis Small Cell Lymphoma
- Marginal Zone Lymphoma
- Nodular Lymphocyte Predominant B-cell Lymphoma (yav tas los hu ua Nodular Lymphocyte Predominant Hodgkin Lymphoma)
- Ib qho tsis txaus ntseeg Mantle Cell Lymphoma
- Waldenstrom's Macroglobulinemia
Nws yog ib qho tseem ceeb kom nkag siab tias feem ntau cov neeg uas muaj cov lymphomas no tsis hloov.
Qee cov neeg uas muaj T-cell lymphoma tseem tuaj yeem hloov pauv, tab sis cov no tseem tsawg dua.
Thaum twg qhov kev hloov pauv feem ntau yuav tshwm sim?
Transformed lymphoma tuaj yeem tshwm sim txhua lub sijhawm, tab sis koj feem ntau yuav muaj kev hloov pauv li 3-6 xyoo tom qab koj tau kuaj pom koj tus mob qog nqaij hlav tsis muaj zog.
Qhov kev pheej hmoo ntawm kev hloov pauv yuav txo qis tom qab nyob nrog koj cov qog ntshav qog ntshav tsis txaus rau 15 xyoo, nrog kev hloov pauv tom qab lub sijhawm no tsawg heev.
Cov tsos mob uas yuav qhia tau tias koj lymphoma tau hloov lawm
Koj tuaj yeem tau txais cov tsos mob B raws li koj cov qog ntshav qog ua haujlwm ntau dua lossis pib hloov pauv
Dab tsi yog qhov kev hloov pauv ntau tshaj plaws?
Qee qhov kev hloov pauv ntau dua li lwm tus. Hauv qab no peb teev cov ntau ntau (txawm tias tseem tsis tshua muaj) kev hloov pauv uas tuaj yeem tshwm sim.
Indolent lymphoma |
Nws tuaj yeem hloov mus rau cov qog ntshav qog ntshav hauv qab no |
| Chronic Lymphocytic Leukemia / Me Lymphocytic Lymphoma (CLL / SLL) |
Hloov mus rau Diffuse Loj B-cell Lymphoma (DLBCL) - qhov kev hloov pauv no hu ua Richter syndrome. Ntau yam tsis tshua muaj, CLL / SLL tuaj yeem hloov mus rau hauv ib qho subtype ntawm Hodgkin Lymphoma. |
| Tshwj Xeeb Lymphoma |
Kev hloov pauv feem ntau yog mus rau Diffuse Loj B-cell Lymphoma (DLBCL). Tsis tshua muaj, tuaj yeem hloov mus rau qhov mob hnyav B-cell lymphoma, nrog cov yam ntxwv ntawm DLBCL thiab Burkitt Lymphoma. |
| Lymphoplasmacytic Lymphoma (tseem hu ua Waldenstrom's macroglobulinemia) | Diffuse Loj B-cell Lymphoma (DLBCL). |
| Mantle Cell Lymphoma (MCL) | Yas (los yog blastoid) MCL. |
| Marginal Zone Lymphomas (MZL) | Diffuse Loj B-cell Lymphoma (DLBCL). |
| Mucosa-Associated Lymphoid Tissue Lymphoma (MALT), ib tug subtype ntawm MZL | Diffuse Loj B-cell Lymphoma (DLBCL). |
| Nodular Lymphocyte-Predominant B-cell Lymphoma (yav tas los hu ua Nodular Lymphocyte-Predominant Hodgkin lymphoma) | Diffuse Loj B-cell Lmphoma (DLBCL). |
| Cutaneous T-cell Lymphoma (CTCL) | Loj Cell Lymphoma. |
Kev kuaj mob thiab theem ntawm Transformed Lymphoma
Yog tias koj tus kws kho mob xav tias koj lub lymphoma tau hloov lawm lawv yuav xav ua ntau yam kev kuaj thiab kuaj. Cov kev ntsuam xyuas yuav suav nrog kev kuaj biopsies los xyuas seb cov qog ntshav qog ntshav tau tsim cov kev hloov pauv tshiab, thiab yog tias tam sim no lawv coj tus cwj pwm zoo li lwm hom qog ntshav qog ntshav, thiab kev soj ntsuam yuav ua rau cov qog ntshav qog ntshav.
Cov kev ntsuam xyuas thiab kev soj ntsuam no yuav zoo ib yam li cov uas koj tau muaj thaum koj thawj zaug kuaj mob qog nqaij hlav. Cov ntaub ntawv los ntawm cov no yuav muab rau koj tus kws kho mob cov ntaub ntawv xav tau los muab koj hom kev kho mob zoo tshaj plaws rau koj qhov hloov pauv lymphoma.
Kev kho mob
Thaum tag nrho koj cov txiaj ntsig tau los ntawm kev kuaj ntshav biopsy thiab kev kuaj mob ua tiav tiav, koj tus kws kho mob yuav tshuaj xyuas lawv los txiav txim siab txog kev kho mob zoo tshaj plaws rau koj. Koj tus kws kho mob kuj tuaj yeem ntsib nrog pab pawg ntawm lwm tus kws tshaj lij los tham txog kev kho mob zoo tshaj plaws thiab qhov no hu ua a Pab neeg ua haujlwm ntau yam kev qhuab qhia (MDT) kev sib ntsib.
Koj tus kws kho mob yuav txiav txim siab ntau yam txog koj cov qog ntshav qog ntshav thiab koj txoj kev noj qab haus huv los txiav txim siab seb puas yog, thiab xav tau kev kho mob dab tsi. Qee yam uas lawv yuav xav txog suav nrog:
- Qhov kev hloov pauv tau tshwm sim li cas (koj tus kab mob qog nqaij hlav tshiab)
- Qhov theem ntawm lymphoma
- Txhua yam tsos mob koj tau txais
- Yuav ua li cas cov lymphoma cuam tshuam rau koj lub cev
- Koj lub hnub nyoog
- Lwm yam teeb meem kho mob uas koj muaj lossis cov tshuaj koj noj
- Koj nyiam thaum koj tau txais tag nrho cov ntaub ntawv koj xav tau.
Hom Kev Kho Mob
Transformed lymphoma yuav tsum tau kho tib yam li cov qog ntshav qog ntshav. Kev kho mob tuaj yeem suav nrog:
- Combination tshuaj kho mob
- Monoclonal antibody
- Autologous qia hloov ntshav ntawm tes (yog tias noj qab nyob zoo)
- Radiotherapy (feem ntau yog nrog chemotherapy)
- Kev kho T-cell kho mob (Chimeric antigen receptor T-cell therapy - tom qab 2 kev kho ua ntej)
- immunotherapy
- Hom kev kho mob
- Kev koom tes nrog kev sim tshuaj
Prognosis ntawm Transformed Lymphoma (TL)
Ntau cov qog ntshav qog ntshav tuaj yeem kho tau, lossis muaj sijhawm ntev ntawm kev tso tawm tom qab kho. Yog li ntawd, muaj kev cia siab tias thaum muab kev kho mob koj tuaj yeem kho tau, lossis muaj kev tso tawm ntev ntev los ntawm qhov hnyav dua, hloov pauv lymphoma. Txawm li cas los xij, koj tseem yuav xav tau kev soj ntsuam ze tom qab koj txoj kev kho mob los kuaj xyuas cov tsos mob ntawm kev rov qab los.
Indolent lymphomas feem ntau tsis tuaj yeem kho tau, yog li txawm tias tom qab kev kho mob rau koj cov qog ntshav qog ntshav, koj tseem yuav muaj qee cov qog ntshav qog ntshav tsis txaus, thiab yog li koj tus kws kho mob yuav xav kuaj qhov no thiab.
Nug koj tus kws kho mob seb koj puas muaj feem yuav kho tau, mus rau hauv kev zam txim thiab tseem nyob nrog cov qog ntshav qog ntshav qab zib tom qab kho koj cov qog ntshav qog ntshav hloov.
Ntsiab lus
- Transformed lymphoma yog qhov tsawg heev, tsuas yog kwv yees li 1-3 ntawm txhua 100 tus neeg uas muaj cov qog ntshav qog ntshav tsis txaus muaj qhov hloov pauv txhua xyoo.
- Kev hloov pauv ntau dua nyob rau hauv cov neeg uas muaj B-cell lymphoma tsis txaus, tab sis tuaj yeem tshwm sim rau cov neeg uas muaj T-cell lymphoma tsis txaus ntseeg thiab.
- Kev hloov pauv ntau dua 3-6 xyoo tom qab koj tau kuaj pom tias muaj cov qog ntshav qog ntshav qis, thiab tsawg heev tom qab 15 xyoo.
- Transformed Lymphoma tuaj yeem tshwm sim yog tias koj cov noob lossis cov qog ntshav qog ntshav tsim cov kev hloov pauv tshiab, hloov txoj kev lymphoma loj hlob thiab coj tus cwj pwm.
- Transformed Lymphoma txawv rau cov qog ntshav qog ntshav tsis txaus "sawv" thiab ua kom nquag plias.
- Tseem muaj peev xwm kho tau los ntawm kev mob qog nqaij hlav ntau dua, tab sis koj tuaj yeem ua neej nyob nrog tus mob qog ntshav qab zib tom qab kho.
- Kev kho mob rau cov qog ntshav qog ntshav hloov pauv yuav raug tsom rau kev kho, lossis muab cov qog ntshav qog ntshav txaus rau hauv kev zam.
- Tshaj tawm txhua yam tshiab thiab tsis zoo Cov tsos mob, nrog rau B-cov tsos mob rau koj tus kws kho mob.
