Kuongorora kwecutaneous (ganda) lymphoma
Lymphoma imhando yegomarara rinotangira mumasero machena anonzi lymphocytes. Aya masero eropa anowanzogara mu lymphatic system yedu, asi anokwanisa kufamba kune chero chikamu chemuviri wedu. Iwo maseru akakosha emushonga wedu wekuzvidzivirira, anorwisa utachiona uye zvirwere, uye anobatsira mamwe masero emuviri wemuviri kushanda zvakanyanya.
Pamusoro peLymphocytes
Tine mhando dzakasiyana dze lymphocytes, nemapoka makuru ari B-cell lymphocytes uye T-cell lymphocytes. Ose maviri B uye T-cell lymphocytes ane basa rakasarudzika, ane "immunological memory". Izvi zvinoreva kuti kana tine utachiona, chirwere, kana mamwe masero edu akakuvadzwa (kana kuchinja), ma lymphocyte edu anoongorora masero aya uye anogadzira "memory B kana T-cells".
Aya maseru ekurangarira anochengeta ruzivo rwese nezve nzira yekurwisa hutachiona, kana kugadzirisa maseru akakuvadzwa kana hutachiona kana kukuvara kukaitika zvakare. Nenzira iyi vanogona kuparadza kana kugadzirisa masero nekukurumidza uye zvinobudirira zvakanyanya nguva inotevera.
- B-cell lymphocytes zvakare inogadzira masoja ekudzivirira chirwere (immunoglobulins) kubatsira kurwisa hutachiona.
- T-masero anobatsira kudzora mhinduro dzedu dzemuviri kuitira kuti immune system yedu ishande nemazvo kurwisa hutachiona, asi zvakare inobatsira kumisa mhinduro yekudzivirira kana hutachiona hwaenda.
Lymphocytes inogona kuva kenza lymphoma masero
Cutaneous lymphomas inoitika kana B-seli kana T-masero anoenda kuganda rako aita kenza. Masero ane kenza lymphoma anobva apatsanura uye anokura zvisingadzoreki, kana kuti haafe paanofanira.
Vese vanhu vakuru nevana vanogona kubatwa necutaneous lymphomas uye vanhu vazhinji vane cutaneous lymphoma vachava nekenza T-cell. Vanenge vashanu chete pavanhu 5 voga voga vane cutaneous lymphoma vachava neB-cell lymphoma.
Cutaneous lymphomas zvakare yakakamurwa kuita:
- Indolent - Indolent lymphomas inononoka kukura uye inowanzopfuura nematanho apo ivo "vakarara" vasingakukuvadzi. Iwe unogona kunge usingade chero kurapwa kana uine indolent cutaneous lymphoma, kunyange vamwe vanhu vachida. Mazhinji indolent lymphomas haaparadziri kune dzimwe nhengo dzemuviri wako, asi mamwe anogona kuvhara nzvimbo dzakasiyana dzeganda. Nokufamba kwenguva, mamwe indolent lymphomas anogona kufambira mberi pachikuva, zvichireva kuti anopararira kune dzimwe nzvimbo dzemuviri wako, asi izvi hazviwanzo neakawanda cutaneous lymphomas.
- Ane utsinye -Aggressive lymphomas ari kukurumidza kukura lymphomas anogona kukura nekukurumidza uye kupararira kune dzimwe nhengo dzemuviri wako. Kana uine aggressive cutaneous lymphoma, iwe uchafanirwa kutanga kurapwa mushure mekunge waonekwa kuti une chirwere.
Zviratidzo zveCutaneous Lymphoma
Indolent cutaneous lymphoma
Iwe unogona kunge usina zviratidzo zvinoonekwa kana uine indolent lymphoma. Nekuti indolent lymphomas inononoka kukura, inokura kwemakore mazhinji, saka kuputika kana ronda paganda rako rinogona kusaonekwa. Kana ukawana zviratidzo zvinogona kusanganisira:
- mapundu asingaendi
- pakafunuka kana nzvimbo dzinorwadza paganda rako
- dzakati sandarara, dzakatsvuka, dzine makwapa paganda
- maronda anogona kutsemuka uye kubuda ropa uye kusapora sezvaitarisirwa
- kutsvuka kwakazara panzvimbo hombe dzeganda
- bundu rimwe chete, kana akawanda paganda rako
- Kana uine ganda rakasviba ganda, unogona kunge uine nzvimbo dzeganda dzakareruka kupfuura dzimwe (panzvimbo yekutsvuka).
Patches, papules, plaques uye tumors - Ndeupi musiyano?
Zvironda zvauinazvo zvine cutaneous lymphomas zvinogona kuve zvakajairika, kana zvinogona kunzi zvigamba, papules, plaques kana mamota.
Patches - kazhinji inzvimbo dzakatsetseka dzeganda dzakasiyana neganda rakaipoteredza. Anogona kunge akatsetseka kana makwapa uye anogona kuita senge rash.
Papules - idiki, dzakasimba dzakasimudzwa nzvimbo dzeganda, uye dzinogona kuita sebundu rakaomarara.
Mapikicha - inzvimbo dzakaoma dzeganda dzinowanzosimudzwa zvishoma, nzvimbo dzakakora dzeganda dzinowanzova nemakwasha. Plaques anogona kazhinji kukanganisa eczema kana psoriasis.
Mamota – mapundu akasimudzwa, mapundu kana mapundu anogona dzimwe nguva kuita maronda asingapore.
Aggressive uye Advanced cutaneous lymphoma
Kana uine hasha kana advanced cutaneous lymphoma, unogona kunge uine chero chezviratidzo zviri pamusoro, asi unogona kunge uine zvimwe zviratidzo. Izvi zvinogona kusanganisira:
- Malymph nodes akazvimba aunogona kuona kana kunzwa sebundu pasi peganda rako - izvi zvinowanzova muhuro, muhapwa kana muchiuno.
- Kuneta kunova kuneta kwakanyanya kwete kuvandudzwa nekuzorora kana kurara.
- Kubuda ropa zvisina kujairika kana mavanga.
- Zvirwere zvinoramba zvichidzoka kana kusapera.
- Kupfupika kwemweya.
- B-zviratidzo.
Cutaneous lymphoma inowanikwa sei?
Iwe unozoda biopsy kana akati wandei biopsies kuti uongorore cutaneous lymphoma. Mhando yebiopsy yauinayo inoenderana nerudzi rwemapundu kana maronda aunawo, kwaanowanikwa pamuviri wako uye kuti akakura sei. Izvo zvakare zvinoenderana nekuti iganda rako chete rinokanganiswa, kana kuti lymphoma yakapararira kune dzimwe nzvimbo dzemuviri wako senge lymph nodes yako, nhengo, ropa kana bone marrow. Mamwe emhando dzebiopsies anogona kukurudzirwa iwe akanyorwa pazasi.
Ganda biopsy
Ganda biopsy ndeye apo sampuli yerash yako kana ronda rabviswa uye rinotumirwa ku pathology kunoongororwa. Mune zvimwe zviitiko, kana uine chironda chimwe chete, chironda chose chinogona kubviswa. Kune nzira dzakasiyana dzekuita ganda biopsy, uye chiremba wako achakwanisa kutaura newe nezve chaiyo yeganda biopsy yemamiriro ako ezvinhu.
Lymph node biopsy
Kana uine lymph nodes yakazvimba inogona kuonekwa kana kunzwika, kana iyo yakaratidza pane zvikero, unogona kuva nebiopsy kuti uone kana lymphoma yakapararira kune lymph nodes yako. Kune miviri miviri mikuru ye lymph node biopsies inoshandiswa kuongorora lymphoma.
Dzinosanganisira:
Core inaliti biopsy - panoshandiswa tsono kubvisa sampuli ye lymph node yako yakakanganisika. Iwe uchave neanesthetic yemunharaunda yekudzikisa nzvimbo kuti usanzwe kurwadziwa panguva iyi. Mune zvimwe zviitiko, chiremba kana radiologist anogona kushandisa Ultrasound kutungamira tsono munzvimbo yakakodzera yebiopsy.
Excisional biopsy - ne excisional biopsy iwe unogona kunge uine general anesthetic saka iwe unorara kuburikidza nemaitiro. Lymph node yose kana lesion inobviswa panguva uye excisional biopsy kuitira kuti node yose kana chironda chikwanise kuongororwa muchirwere chezviratidzo zve lymphoma. Iwe unogona kunge uine mashoma mashoma uye yekupfeka paunomuka. Mukoti wako achakwanisa kutaura newe nezve machengetero eronda, uye rini/kana uchizofanira kubviswa matinji.
Subtypes ye indolent cutaneous T-cell lymphomas
Mycosis Fungoides ndiyo inonyanya kuzivikanwa subtype ye indolent cutaneous T-cell lymphoma. Inowanzobata vakuru vakuru, uye varume zvishoma kakawanda kupfuura vakadzi, zvisinei vana vanogonawo kukura MF. Muvana inobata vakomana nevasikana zvakaenzana uye inowanzoonekwa pazera remakore gumi.
MF inowanzokanganisa ganda rako chete, asi anenge 1 muvanhu gumi anogona kunge aine hasha mhando yeMF inogona kupararira kumalymph nodes ako, ropa uye nhengo dzemukati. Kana uine MF ine hukasha, unozoda kurapwa kwakafanana nemarapiro anopiwa kune mamwe T-cell lymphoma ane hukasha.
Primary cutaneous ALCL is indolent (inokura zvishoma) lymphoma inotanga muT-cell muzvikamu zveganda rako.
Iyi mhando ye lymphoma dzimwe nguva inonzi subtype ye cutaneous lymphoma uye dzimwe nguva inonzi subtype ye Anaplastic Large Cell Lymphoma (ALCL). Chikonzero chezvikamu zvakasiyana ndechekuti masero e-lymphoma ane maitiro akafanana kune mamwe marudzi eALCL akadai semasero makuru kwazvo anotaridzika akasiyana zvakanyanya neT-cells ako. Zvisinei, kazhinji zvinongokanganisa ganda rako uye rinokura zvishoma nezvishoma.
Kusiyana nehukasha subtypes ye cutaneous lymphoma uye ALCL, ungasada chero kurapwa kwePcALCL. Iwe unogona kugara nePcALCL kwehupenyu hwako hwose, asi zvakakosha kuziva, kuti iwe unogona kurarama zvakanaka nayo, uye inogona kunge isina kukanganisa pahutano hwako. Kazhinji zvinongobata ganda rako uye very rarely inopararira kupfuura ganda rako kune dzimwe nhengo dzemuviri wako.
PcALCL inowanzotanga nepundu kana mapundu paganda rako anogona kunge achikwenya kana kurwadza, asi anogonawo kusakukonzera kusagadzikana. Dzimwe nguva, zvinogona kuita seronda risingapore sezvaungatarisira kuti riite. Chero marapirwo ePCALCL anogona kunge ari ekuvandudza chero kukwenya kana kurwadziwa, kana kuvandudza kutaridzika kweiyo lymphoma pane kurapa iyo lymphoma pachayo. Nekudaro, kana PCALCL ichingobata nzvimbo diki kwazvo yeganda, inogona kubviswa nekuvhiyiwa kana kuburikidza neradiotherapy.
PcALCL inowanzoonekwa muvanhu vane makore ari pakati pe50-60 makore, asi inogona kubata chero munhu wezera ripi zvaro, kusanganisira vana.
SPTCL inogona kuitika muvana nevakuru asi inowanzoitika kune vanhu vakuru, ine avhareji yezera rekuongororwa iine makore makumi matatu nematanhatu. Inotumidzwa izvi nekuti inoratidzika sechimwe chiitiko chinonzi panniculitis, chinoitika kana mafuta ari pasi peganda azvimba, zvichiita kuti mapundu atange. Anenge munhu mumwe chete pavashanu vane SPTCL achavawo nechirwere che auto-immune chiripo chinoita kuti immune system yako irwise muviri wako.
SPTCL inoitika kana T-masero ane kenza achienda uye anoramba ari mukati memukati meganda rako uye mafuta tishu, zvichiita kuti mapundu auye pasi peganda rako raunogona kuona kana kunzwa. Iwe unogona kutoona mamwe ma plaque paganda rako. Maronda mazhinji akatenderedza 2cm muhukuru kana pasi.
Zvimwe zvinokonzeresa zvaunogona kuwana ne SPTCL zvinosanganisira:
- magwamba eropa kana kubuda ropa zvisina kujairika
- chills
- haemophagocytic lymphohistiocytosis - mamiriro ekuti iwe une akawandisa akabatiswa masero edziviriro anokonzeresa kukuvadza kune mwongo wako, masero eropa ane hutano uye nhengo.
- Chiropa chakakura uye/kana spleen.
Lymphomatoid papulosis (LyP) inogona kukanganisa vana nevakuru. Haisi kenza saka zviri pamutemo haisi mhando ye lymphoma. Nekudaro, inoonekwa seyakatangira yeT-cell lymphoma yakadai seMycosis Fungoides kana Primary Cutaneous Anaplastic Large Cell Lymphoma, uye kazhinji kacho. Hodgkin Lymphoma. Kana iwe wakaonekwa uine chirwere ichi ungasada chero kurapwa, asi unozotariswa zvakanyanya nachiremba wako kune chero zviratidzo zveLP inoshanduka kuita cancer.
Chirwere chinokanganisa ganda rako apo unogona kunge uine mapundu anouya achipfuura paganda rako. Maronda anogona kutanga zvishoma uye kukura. Vanogona kutsemuka uye kubuda ropa vasati vaoma uye voenda pasina kupindira kwekurapa. Zvinogona kutora mwedzi miviri kuti zvironda zvipere. Zvisinei, kana vakakonzera marwadzo kana kukwenya kana zvimwe zviratidzo zvisingafadzi unogona kuwana kurapwa kwekuvandudza zviratidzo izvi.
Kana iwe uchiwanzo batwa nemapundu kana maronda akadai, ona chiremba wako kuti uwane biopsy.
Subtypes ye indolent B-cell cutaneous lymphomas
Primary Cutaneous Follicle Center Lymphoma (pcFCL) indolent (inokura zvishoma) B-cell lymphoma. Izvo zvakajairika munyika dzekumadokero uye zvinobata varwere vakura, neavhareji yezera rekuongororwa iri makore makumi matanhatu.
Iyi ndiyo inonyanya kuzivikanwa subtype yeCutaneous B-Cell Lymphoma. Inowanzo indolent (inononoka kukura) uye inokura nemwedzi, kana kunyange makore. Inowanzoita semapundu matsvuku kana shava maronda paganda remusoro wako, mutsipa, chipfuva, kana dumbu. Vanhu vazhinji havazombodi kurapwa kwepcFCL asi kana uine zviratidzo zvisingafadzi, kana kuti uchinetseka nekutaridzika kwayo, unogona kupihwa kurapwa kwekuvandudza zviratidzo kana kutaridzika kweiyo lymphoma.
Primary Cutaneous Marginal Zone Lymphoma (pcMZL) ndiyo yechipiri inonyanya kuzivikanwa subtype yeB-cell cutaneous lymphomas uye inobata varume zvakapetwa kaviri kupfuura vakadzi, zvisinei inogonawo kuitika muvana. Inowanzoonekwa kune vanhu vakwegura vane makore anopfuura makumi mashanu, uye vanhu vakambove nehutachiona hwechirwere cheLyme.
Kuchinja kweganda kunogona kuitika munzvimbo imwechete, kana munzvimbo dzinoverengeka dzakatenderedza muviri wako. Kazhinji kazhinji inotangira pamaoko ako, pachipfuva kana kumashure sepingi, dzvuku kana pepuru zvigamba kana mapundu.
Shanduko idzi dzinoitika kwenguva yakareba, saka dzinogona kusanyanya kuoneka. Iwe unogona kunge usingade chero kurapwa kwepcMZL, asi marapirwo anogona kupihwa kana uine zviratidzo zviri kukukonzera kunetseka.
Iyi ishoma shoma yeCBCL inowanikwa muvarwere vasina immune panjodzi uye vakave nehutachiona hweEpstein-Barr - hutachiona hunokonzera glandular fever.
Iwe unogona kunge uine ronda rimwe chete paganda rako kana mudumbu rako kana mumuromo. Vanhu vazhinji havadi kurapwa kwerudzi rudiki urwu rweCBCL. Nekudaro, kana iwe uri kutora immunosuppressive mishonga, chiremba wako anogona kuongorora dosi kuti abvumire immune system yako kupora zvishoma.
Muzviitiko zvisingawanzoitiki, ungada kurapwa ne monoclonal antibody kana anti-viral mishonga.
Subtypes yeAggressive Lymphoma
Sezary Syndrome inodaidzwa kudaro nekuti maT-cell ane gomarara anonzi Sezary masero.
Ndiyo yakanyanya hutsinye T-cell lymphoma (CTCL) uye kusiyana nemamwe marudzi eCTCL, lymphoma (Sezary) masero anowanikwa kwete chete muzvikamu zveganda rako, asiwo muropa rako uye mwongo. Vanogonawo kupararira kune lymph nodes yako nedzimwe nhengo.
Sezary Syndrome inogona kubata chero ani zvake asi inowanzoitika muvarume vane makore anopfuura makumi matanhatu ezera.
Zviratidzo zvaunogona kuwana neSezary Syndrome zvinosanganisira:
- B-zviratidzo
- kukoira kwakanyanya
- kuzvimba lymph nodes
- kuzvimba chiropa uye / kana spleen
- kukora kweganda pazvanza zvemaoko ako kana pasi petsoka dzako
- kukobvura kwemunwe wako nezvigunwe
- bvudzi rinopera
- kudonha kwechivharo cheziso rako (iyi inonzi ectropion).
Nekuda kwekukura nekukurumidza kwemasero eSezary, unogona kupindura zvakanaka chemotherapy inoshanda nekuparadza masero ari kukurumidza kukura. Nekudaro, kudzoka zvakare kwakajairika neSezary Syndrome, zvichireva kuti kunyangwe mushure mekupindura kwakanaka, zvingangoita kuti chirwere ichi chidzoke uye chinoda kurapwa kwakawanda.
Iyi i T-cell lymphoma isingawanzowanikwi uye ine hukasha inokonzeresa maronda akawanda eganda kukura nekukurumidza paganda pamusoro pemuviri wese. Maronda acho anogona kunge ari papules, nodules kana mapundu anogona kuita maronda oita semaronda akavhurika. Mamwe anogona kutaridzika kunge ma plaque kana zvigamba uye mamwe anogona kubuda ropa.
Zvimwe zviratidzo zvinogona kusanganisira:
- B-zviratidzo
- Kufirwa kwechido
- manyaro
- chirwere
- kurutsa
- kuzvimba lymph nodes
- chiropa chakawedzera kana spleen.
Nekuda kwehunhu hwehasha, PCAETL inogona kupararira kunzvimbo dziri mukati memuviri wako dzinosanganisira lymph nodes nedzimwe nhengo.
Iwe unozoda kurapwa nechemotherapy nekukurumidza mushure mekuongororwa.
Primary Cutaneous (ganda) Diffuse Hombe B-sero lymphoma is a isingawanzo subtype ye lymphoma inobata zvishoma pane 1 kubva kune zana vanhu vane NHL.
Izvi hazvishamisi pane mamwe madiki eCutaneous B-Cell Lymphomas. Inowanzoitika muvakadzi kupfuura varume uye inowanzoita zvehasha kana kukurumidza kukura. Zvinoreva kuti pamwe nekukanganisa ganda rako, rinogona kukurumidza kupararira kune dzimwe nhengo dzemuviri wako, kusanganisira lymph nodes yako nedzimwe nhengo.
Inogona kukura kwemavhiki kusvika kumwedzi, uye inowanzobata vanhu vakwegura vari pasi pemakore makumi manomwe nemashanu. Inowanzotanga pamakumbo ako (Leg-type) seimwe kana akawanda maronda / mamota asi anogona zvakare kukura pamaoko ako uye torso (chipfuva, musana uye dumbu).
Inonzi Primary Cutaneous Diffuse Large B-cell Lymphoma nekuti nepo ichitanga mumaB-cell ari muzvikamu zveganda rako, masero elymphoma akafanana neanowanikwa mune mamwe madiki eDiffuse Large B-cell Lymphoma (DLBCL). Nechikonzero ichi, iyi subtype ye cutaneous B-cell Lymphoma inowanzobatwa zvakafanana kune mamwe madiki eDLBCL. Kuti uwane rumwe ruzivo nezveDLBCL, tinya pano.
Kuongororwa kweCutaneous Lymphoma
Kana zvave zvichisimbiswa kuti une cutaneous lymphoma, iwe uchada kuongororwa kwakawanda kuti uone kana lymphoma yakapararira kune dzimwe nhengo dzemuviri wako.
Kuongorora kwepanyama
Chiremba wako achaita kuongorora kwepanyama uye kutarisa ganda muviri wako wose kuti uone kuti yakawanda sei yeganda rako inobatwa ne lymphoma. Vanogona kukumbira mvumo yako kuti vatore mapikicha kuitira kuti vave nerekodhi yezvaitaridzika sei usati watanga chero kurapwa. Vanozoshandisa izvi kutarisa kana paine kuvandudzwa nekurapwa. Mvumo isarudzo yako, haufanirwe kuve nemapikicha kana usinganzwe kugadzikana neizvi, asi kana ukabvuma, unozofanirwa kusaina fomu remvumo.
Positron Emission Tomography (PET) Scan
A PET scan is scan yemuviri wako wese. Inoitwa muchikamu chakakosha chechipatara chinonzi "nuclear medicine" uye iwe uchapihwa jekiseni remushonga weradioactive uyo chero lymphoma cell inomwa. Kana scan yatorwa, nzvimbo dzine lymphoma dzinobva dzavheneka pa scan kuratidza pane lymphoma nehukuru uye chimiro chayo.
Computed Tomography (CT) scan
A CT scan ndeye yakasarudzika X-ray inotora 3 dimensional mifananidzo yemukati memuviri wako. Zvinowanzotora scan yenzvimbo yemuviri wako yakadai sechipfuva chako, dumbu kana pelvis. Iyi mifananidzo inogona kuratidza kana wakazvimba lymph nodes mukati memuviri wako, kana nzvimbo dzinotaridzika kuva kenza munhengo dzako.
Bone Marrow Biopsy
Vanhu vazhinji vane cutaneous lymphoma havazodi bhonzo biopsy. Zvisinei, kana uine subtype ine hutsinye, ungada imwe kuti uone kana lymphoma yakapararira kumapfupa ako.
Mhando mbiri dzebiopsies dzinotorwa panguva yepfupa biopsy:
- Bone marrow aspirate (BMA): bvunzo iyi inotora shoma shoma yemvura inowanikwa munzvimbo yemwongo
- Bone marrow aspirate trephine (BMAT): bvunzo iyi inotora diki diki yemwongo tishu
TNM/B staging system ye cutaneous lymphoma
Kurongeka kwecutaneous lymphoma kunoshandisa nzira inonzi TNM. Kana uine MF kana SS pachawedzerwa tsamba - TNMB.
T = saizi ye Tumour - kana kuti yakawanda sei yemuviri wako inobatwa ne lymphoma.
N = lymph Nodes inobatanidzwa - inotarisa kana lymphoma yaenda kune lymph nodes yako, uye ingani lymph nodes ine lymphoma mairi.
M = Metastasis - inotarisa kana, uye kuti lymphoma yakapararira sei mukati memuviri wako.
B = Blood - (MF kana SS chete) inotarisa kuti lymphoma yakawanda sei muropa rako uye mwongo.
TNM/B Chimiro cheCutaneous Lymphoma |
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Cutaneous Lymphoma |
Mycosis fungoides (MF) kana Sezary Syndrome (SS) chete |
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TTumorkana gandaakabatwa |
T1 – une chironda chimwe chete.T2 - une ganda rinopfuura rimwechete asi maronda ari munzvimbo imwe chete, kana nzvimbo mbiri dziri pedyo muviri wako.T3 - une maronda munzvimbo dzakawanda dzemuviri wako. |
T1 - isingasviki 10% yeganda rako rinokanganiswa.T2 - inopfuura 10% yeganda rako rinokanganiswa.T3 - une bundu rimwe chete kana akawanda akakura kupfuura 1cm.T4 - une erythema (yakatsvuka) inofukidza zvinopfuura makumi masere muzana emuviri wako. |
NRwiyoNodes |
N0 - lymph nodes yako kuoneka zvakajairika.N1 - rimwe boka remalymph nodes rinobatanidzwa.N2 - Mapoka maviri kana anopfuura emalymph nodes anokanganisa mumutsipa wako, pamusoro pe clavicle yako, underarms, chidya kana mabvi.N3 - lymph nodes mukati, kana pedyo nechipfuva chako, mapapu nemhepo, mitsipa mikuru yeropa (aortic) kana mahudyu inobatanidzwa. |
N0 -Malymph nodes ako anoita seakajairika.N1 - une lymph nodes abnormal ine yakaderera giredhi shanduko.N2 -Une abnormal lymph nodes ane high giredhi shanduko.Nx - une lymph nodes abnormal, asi giredhi harizivikanwe. |
MMetastasis(paradzira) |
M0 - hapana ye lymph nodes yako inokanganisa.M1 - lymphoma yakapararira kune lymph nodes yako kunze kweganda rako. |
M0 - hapana nhengo yako yemukati inobatanidzwa, yakadai semapapu, chiropa, itsvo, uropi.M1 - lymphoma yakapararira kune imwe kana kupfuura yenhengo dzako dzomukati. |
Bropa |
N / A |
B0 - isingasviki 5% (5 kubva pazana rega rega) lymphocytes ane kenza muropa rako.Aya masero ane gomarara muropa rako anonzi Sezary masero.B1 -Kupfuura 5% ye lymphocytes muropa rako maseru eSezary.B2 - Anopfuura 1000 Sezary masero mudiki diki (1 microliter) yeropa rako. |
Chiremba wako angashandisa mamwe mavara akadai se "a" kana "b" kuti awedzere kutsanangura masero ako e-lymphoma. Izvi zvinogona kureva saizi ye lymphoma yako, matarisiro anoita masero, uye kuti ese akabva kune rimwe sero risina kujairika (clones) kana anopfuura sero rimwechete risina kujairika.Kumbira chiremba wako kuti atsanangure nhanho yako yega uye giredhi, uye zvazvinoreva pakurapwa kwako. |
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Kurapa kweIndolent Cutaneous Lymphoma
Yakawanda indolent lymphomas haigone kuporeswa zvakadaro zvisinei neizvi, vanhu vazhinji vane indolent cutaneous lymphomas havazombodi kurapwa.
Indolent cutaneous lymphomas zvakare kazhinji haina kukuvadza kuhutano hwako, saka chero kurapwa kwauinayo kuchave kugadzirisa zviratidzo zvako pane kurapa chirwere chako.
Zvimwe zviratidzo zvinogona kubatsira kubva mukurapwa zvinosanganisira:
- marwadzo
- itching
- maronda kana maronda anoramba achibuda ropa
- kunyara kana kuzvidya mwoyo kwakabatana nenzira iyo lymphoma inotarisa.
Mhando dzekurapa dzinogona kusanganisira zvinotevera.
Munzvimbo kana ganda rinotungamirirwa kurapwa.
Mishonga yemusoro makirimu aunokwesha munzvimbo ye lymphoma, nepo ganda rinotungamirwa kurapwa rinogona kusanganisira radiotherapy kana phototherapy. Pazasi pane muchidimbu mamwe marapirwo aungangopihwa.
Corticosteroids - ane chepfu kune lymphoma masero uye anobatsira kuvaparadza. Vanogonawo kuderedza kuzvimba uye kubatsira kuvandudza zviratidzo zvakaita sekukwenya.
Retinoids - ndiyo mishonga yakafanana nevhitamini A. Inogona kubatsira kuderedza kuzvimba, uye kugadzirisa kukura kwemasero paganda. Izvo zvinoshandiswa zvishoma kazhinji, asi zvinobatsira mune mamwe marudzi eganda lymphoma.
Phototherapy - imhando yekurapa inoshandisa mwenje wakasarudzika (kazhinji UV) panzvimbo dzeganda rako dzakabatwa ne lymphoma. Iyo UV inovhiringidza maitiro ekukura kwemasero, uye nekukuvadza maitiro ekukura, lymphoma inoparadzwa.
Radiotherapy - inoshandisa X-rays kukonzera kukuvadzwa kweDNA yesero (iyo genetic material yesero) izvo zvinoita kuti zvisaite kuti lymphoma igadzirise pachayo. Izvi zvinoita kuti sero rife. Zvinowanzotora mazuva mashoma kana kunyange mavhiki mushure mekurapa kwemwaranzi kwatanga kuti masero afe. Izvi zvinogona kugara kwemwedzi yakati wandei, zvichireva kuti cancer lymphoma masero munzvimbo inorapwa anogona kuparadzwa kunyangwe mwedzi mushure mekupedza kurapwa.
Mune zvimwe zviitiko iwe unogona kuvhiyiwa, ingave pasi penzvimbo kana general anesthetic kubvisa nzvimbo yese yeganda inobatwa ne lymphoma. Izvi zvinonyanya kuitika kana uine ronda rimwechete kana maronda madiki akati wandei. Inonyanya kushandiswa sechikamu chegadziriro yekuongorora lymphoma yako, panzvimbo yekurapa kunyange zvakadaro.
Kurapa kwakarongeka
Kana iwe uine nzvimbo dzakawanda dzemuviri wako dzinobatwa neiyo lymphoma, unogona kubatsirwa kubva kune systemic kurapwa senge chemotherapy, immunotherapy kana yakanangwa kurapwa. Izvi zvinotsanangurwa zvakadzama pasi pechikamu chinotevera - Kurapa aggressive cutaneous lymphoma.
Kurapa kweAggressive kana Advanced Cutaneous Lymphoma
Aggressive uye/kana advanced cutaneous lymphomas inobatwa zvakafanana kune mamwe marudzi ehasha lymphoma uye anogona kusanganisira:
Kurapa kwakarongeka
Chemotherapy imhando yekurapa inorwisa zvakananga maseru ari kukurumidza kukurumidza, saka inogona kushanda pakuparadza lymphoma inokura nekukurumidza. Asi haigone kusiyanisa maseru ane hutano nekenza ari kukurumidza kukurumidza kukura, saka inogona kukonzera mamwe maitiro asingadiwe akadai sekudonha kwebvudzi, kuda kurutsa uye kurutsa, kana manyoka kana kuvimbiswa.
Immunotherapies inogona kubatsira immune system yako kuwana uye kurwisa lymphoma zvakanyanya. Vanogona kuita izvi nenzira dzakawanda. Mamwe, akadai semamonoclonal antibodies anonamatira kune lymphoma kubatsira immune system yako "kuona" lymphoma kuitira kuti ione nekuiparadza. Vanokwanisawo kukanganisa chimiro che lymphoma cell wall, zvichiita kuti vafe.
- Rituximab muenzaniso wemonoclonal antibody inogona kushandiswa kurapa kuuya B-cell lymphomas kusanganisira cutaneous B-cell lymphoma kana vane CD20 marker pavari.
- Mogamulizumab muenzaniso wemonoclonal antibody yakatenderwa vanhu vane Mycosis Fungides kana Sezary Syndrome.
- Brentuximab vedotin muenzaniso we "conjugated" monoclonal antibody inotenderwa kune mamwe marudzi e T-sero lymphoma ine CD30 marker pavari. Iine muchetura wakasungirirwa (conjugated) kune antibody, uye antibody inoburitsa muchetura wakananga musero re lymphoma kuti uiparadze kubva mukati.
Mamwe, akadai se interleukins uye interferon mapuroteni anokosha anowanzoitika mumitumbi yedu, asi anogonawo kutorwa semushonga. Ivo vanoshanda nekusimudzira immune system yako, vachiibatsira kumutsa mamwe masero edziviriro, uye nekuudza muviri wako kuti uite mamwe masero ekudzivirira ekurwisa lymphoma.
Iwe unogona kunge uine immunotherapies wega, kana musanganiswa nemamwe marudzi ekurapa akadai sechemotherapy.
Mishonga inotarirwa mishonga yakagadzirwa inotarisa chimwe chinhu chakananga kune lymphoma cell, saka inowanzova nemigumisiro shoma pane mamwe marapirwo. Iyi mishonga inoshanda nekuvhiringidza zviratidzo zvinonzi lymphoma masero anoda kurarama. Kana dzikasawana zviratidzo izvi, masero elymphoma anomira kukura, kana kufa nenzara nekuti haawane chikafu chaanoda kuti ararame.
Stem cell kuisirwa
Stem cell transplants inoshandiswa chete kana lymphoma yako isingapinduri kune mamwe marapirwo (inoramba), kana kuti inodzoka mushure menguva yekuregererwa (kudzokazve). Kurapwa kwematanho akawanda uko wako, kana masero emupiro (masero eropa asati akura kwazvo) anobviswa kuburikidza nemaitiro anonzi apheresis, obva apihwa kwauri pane imwe nguva, mushure mekunge wawana chemotherapy yakanyanya.
Ne cutaneous lymphoma, zvinowanzoitika kuti iwe ugamuchire stem masero kubva kune anopa kwete yako. Iyi mhando ye stem cell transplant inodaidzwa kuti Allogeneic Stem Cell transplant.
Extracorporeal photopheresis (ECP)
Extracorporeal photopheresis kurapwa kunoshandiswa zvakanyanya kune yepamusoro MF uye SS. Iyo inzira ye "kugeza" ropa rako uye kuita kuti masero ako ekudzivirira awedzere kushanda kune lymphoma kuita kuti lymphoma masero aurawe. Kana muchida kurapwa uku, chiremba wenyu anozokwanisa kukupai mamwe mashoko.
Clinical Trials
Zvinokurudzirwa kuti chero nguva yaunoda kutanga kurapwa iwe unobvunza chiremba wako nezve kliniki miedzo iwe unogona kukodzera. Miedzo yemakiriniki yakakosha kuwana mishonga mitsva, kana misanganiswa yemishonga yekuvandudza kurapwa kwecutaneous lymphoma mune ramangwana.
Vanogona zvakare kukupa mukana wekuyedza mushonga mutsva, musanganiswa wemishonga kana kumwe marapirwo ausingakwanise kuwana kunze kwekuedzwa. Kana iwe uchida kutora chikamu muchirongwa chekiriniki, bvunza chiremba wako kuti ndeapi miedzo yekiriniki yaunokodzera.
Kune marapirwo mazhinji uye misanganiswa yekurapa mitsva iri kuedzwa pari zvino mukuedzwa kwekiriniki pasi rese kune varwere vane vese vachangobva kuongororwa uye vadzoka zvakare cutaneous lymphomas.
Nzira dzekurapa dzeaggressive kana late-stage cutaneous lymphoma | |
B-cell cutaneous | T-cell cutaneous |
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Zvakare bvunza wako wehematologist kana oncologist nezve chero miedzo yekiriniki yaungakodzera. | |
Chii chinoitika kana kurapwa kusingashande, kana lymphoma inodzoka
Dzimwe nguva kurapwa kwe lymphoma hakushandi pakutanga. Kana izvi zvaitika zvinonzi refractory lymphoma. Mune zvimwe zviitiko, kurapwa kunogona kushanda zvakanaka, asi mushure menguva yekuregererwa lymphoma inogona kudzoka - izvi zvinonzi kudzoka zvakare.
Pasinei nokuti une chirwere chekare kana kuti refractory lymphoma, chiremba wako achada kuedza kurapwa kwakasiyana kunogona kukushandira zviri nani kwauri. Mishonga inotevera iyi inodaidzwa kuti kurapwa kwechipiri, uye inogona kushanda zvakanyanya kupfuura yekutanga kurapwa.
Taura nachiremba wako pamusoro pezvinotarisirwa nemishonga yako, uye chirongwa chichava chei kana chimwe chazvo chikasashanda.
Chii chekutarisira kana kurapwa kwapera
Kana wapedza kurapa kwako chiremba wako nyanzvi anenge achiri kuda kukuona nguva dzose. Munozogara muchiongororwa kusanganisa ropa nekuvhenekwa. Kangani kaunenge uine bvunzo idzi zvinoenderana nemamiriro ako pachako uye wako wehematologist achakwanisa kukuudza kuti vanoda kukuona kakawanda sei.
Inogona kuva nguva inofadza kana nguva inoshungurudza paunopedza kurapwa - dzimwe nguva zvose. Hapana nzira yakanaka kana yakaipa yekunzwa. Asi zvinokosha kuti utaure nezvemanzwiro ako uye zvaunoda nevaunoda.
Rutsigiro runowanikwa kana uri kuomerwa nekupedza kurapwa. Taura nechikwata chako chekurapa - chiremba wako weropa kana mukoti wegomarara sezvo vangangokwanisa kukuendesa kunopihwa mazano muchipatara. Chiremba wepanzvimbo yako (general practitioner - GP) anogonawo kubatsira pane izvi.
Lymphoma Care Nurses
Iwe unogona zvakare kupa mumwe wedu Lymphoma Care Nurses kufona kana email. Ingobaya bhatani rekuti "Contact Us" pazasi pescreen kuti uwane ruzivo.
pfupiso
- Cutaneous lymphoma is a subtype yeNon-Hodgkin Lymphoma inokonzerwa nekenza masero eropa anonzi lymphocytes, achifamba uye anogara muzvikamu zveganda rako.
- Indolent Cutaneous Lymphomas inogona kunge isingade kurapwa nekuti kazhinji haina njodzi kuhutano hwako, asi iwe unogona kurapwa kuti utarise zviratidzo kana zvichiita kuti unzwe kusagadzikana, kana kuti lymphoma ikapararira kune lymph nodes yako kana dzimwe nhengo dzemuviri wako.
- Aggressive Cutaneous Lymphomas inoda kurapwa mushure mekunge waonekwa.
- Kune akatiwandei akasiyana machiremba enyanzvi anogona kutarisira kutarisira kwako, uye izvi zvinoenderana nemamiriro ako ega ega.
- Kana lymphoma yako iri kukanganisa hutano hwako hwepfungwa kana mafungiro unogona kukumbira chiremba wako kuti atumire kune chiremba wepfungwa kuti akubatsire kurarama.
- Mishonga yakawanda ine chinangwa chekuvandudza zviratidzo zvako; zvisinei, ungangodawo marapiro ekutarisira lymphoma, uye izvi zvinogona kusanganisira chemotherapy, monoclonal antibodies, kurapa kwakanangwa uye stem cell transplants.
