Mhedziso yeTransformed Lymphoma (TL)
Transformed lymphoma inoitika apo indolent lymphoma yako inoshanduka, uye inova lymphoma ine hutsinye ine maficha emhando yakasiyana ye lymphoma. Izvi zvakasiyana kune yako indolent lymphoma "kumuka" kana kuwedzera kushanda uye inoda kurapwa. Mune zvimwe zviitiko, iwe unogona kunge uine masero e-lymphoma ane indolent uye ane hutsinye sezvo lymphoma inopinda nenzira yekushandura.
Indolent lymphomas inowanzoumbwa nemasero maduku, anononoka kukura. Zvisinei, kana mazhinji emasero aya akatanga kukura, uye nokukurumidza, lymphoma inotanga kuita se lymphoma ine hutsinye yakadai seDiffuse Large B-cell Lymphoma (DLBCL). Hazvishamisi kana iwe uine lymphoma yakashandurwa, kuva nemasero e-lymphoma akavhenganiswa, mamwe asina indolent uye mamwe ane hasha.
Zvinangwa zvekurapa kune yako indolent kana yakashandurwa lymphoma
Mazhinji indolent lymphomas achapfuura nematanho avanorara nekumuka. Zvisinei, kana indolent lymphoma yako inowedzera kushanda uye inoda kurapwa, iwe uchava nemishonga inotungamirirwa pakugadzirisa indolent lymphoma yako.
Nekudaro, kana yako indolent lymphoma shanduko mune aggressive subtype ye lymphoma, iwe unogona kunge uine kurapwa kunonangana pakurapa, kana kuisa iyo ine hutsinye lymphoma mukuregererwa.
Sei shanduko ichiitika?
Lymphoma inogona kushandura apo masero e-lymphoma, kana majini anopa mirayiridzo kumasero ako anovandudza genetic mutations. Aya machinjiro matsva anogona kuve mhedzisiro yekurapwa kwekare kwegomarara, kana kuti zvinogona kuitika pasina chikonzero chinozivikanwa. Kuchinja kwemajini kunogona kuchinja nzira iyo lymphoma inokura uye maitiro, zvichiita kuti pave nehukasha.
Ndiani anobatwa neTransformed Lymphoma?
Chero ani ane low-grade lymphoma kana indolent lymphoma ari pangozi yekuchinja. Zvisinei hazviwanzoitiki, uye zvinongoitika muvanhu 1 kusvika ku3 muvanhu zana vane indolent lymphoma gore negore (100-1%).
Iwe uchave nenjodzi yakakwira zvishoma yekushandurwa kana uine chirwere chakanyanya (bundu hombe kana mapundu) paunotanga kuonekwa kuti une indolent lymphoma.
Iyo inonyanya kuzivikanwa indolent lymphomas inogona kushandura inosanganisira B-cell lymphoma yakadai se:
- Follicular Lymphoma
- Chronic Lymphocytic Leukemia kana Diki Cell Lymphoma
- Marginal Zone Lymphoma
- Nodular Lymphocyte Predominant B-cell Lymphoma (yaimbonzi Nodular Lymphocyte Predominant Hodgkin Lymphoma)
- Indolent Mantle Cell Lymphoma
- Waldenstrom's Macroglobulinemia
Zvakakosha kunzwisisa kuti vanhu vazhinji vane lymphomas idzi havashanduki.
Vamwe vanhu vane indolent T-cell lymphoma vanogonawo kuva neshanduko, asi izvi zvakatonyanya.
Kuchinja kunonyanya kuitika riini?
Kushandurwa lymphoma kunogona kuitika chero nguva, asi iwe unogona kunge uine shanduko makore 3-6 mushure mekunge waonekwa kuti une indolent lymphoma.
Ngozi yekushandurwa inoderera zvakanyanya mushure mekugara neine indolent lymphoma yako kwemakore gumi nemashanu, nekushandurwa mushure menguva ino kuve kushoma.
zviratidzo izvo zvinogona kuratidza kuti lymphoma yako yachinja
Iwe unogonawo kuwana B-zviratidzo sezvo lymphoma yako inowedzera kushanda kana inotanga kuchinja
Ndezvipi zvinonyanya kushandurwa?
Dzimwe shanduko dzinonyanya kuwanda kune dzimwe. Pazasi isu tinonyora izvo zvakajairika (kunyangwe zvichiri zvisingawanzo) shanduko dzinogona kuitika.
Indolent lymphoma |
Inogona kushandura kuita inotevera lymphoma |
| Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) |
Shanduko kuDiffuse Huru B-cell Lymphoma (DLBCL) - shanduko iyi inonzi Richter syndrome. Zvakawanda kashoma, CLL/SLL inogona kushandura kuita classical subtype yeHodgkin Lymphoma. |
| Follicular Lymphoma |
Shanduko inonyanyozivikanwa ndeye Diffuse Large B-cell Lymphoma (DLBCL). Kashoma, inogona kushandura kuita B-cell lymphoma ine hukasha, ine maficha ezvese DLBCL neBurkitt Lymphoma. |
| Lymphoplasmacytic Lymphoma (inonziwo Waldenstrom's macroglobulinemia) | Diffuse Large B-cell Lymphoma (DLBCL). |
| Mantle Cell Lymphoma (MCL) | Blastic (kana blastoid) MCL. |
| Marginal Zone Lymphomas (MZL) | Diffuse Large B-cell Lymphoma (DLBCL). |
| Mucosa-Associated Lymphoid Tissue Lymphoma (MALT), chikamu cheMZL | Diffuse Large B-cell Lymphoma (DLBCL). |
| Nodular Lymphocyte-Predominant B-cell Lymphoma (yaimbonzi Nodular Lymphocyte-Predominant Hodgkin lymphoma) | Diffuse Huru B-cell Lmphoma (DLBCL). |
| Cutaneous T-cell Lymphoma (CTCL) | Yakakura Cell Lymphoma. |
Kuongororwa uye kurongwa kweShanduko Lymphoma
Kana chiremba wako achifungidzira kuti lymphoma yako yakashandura ivo vachada kuita mimwe miedzo uye scans. Miedzo iyi inosanganisira mabiopsies ekutarisa kana masero e-lymphoma akagadzira shanduko nyowani, uye kana iye zvino ave kuita senge akasiyana subtype ye lymphoma, uye ma scan achave ekutanga lymphoma.
Aya maedzo uye scans achafanana neawaive nawo pawakatanga kuwanikwa uine lymphoma. Ruzivo kubva kune izvi ruchapa chiremba wako ruzivo runodiwa kuti akupe iwe yakanakisa mhando yekurapa yako yakashandurwa lymphoma.
mabatiro
Kana zvese zvawawana kubva kubiopsy uye mastaging scans zvapera, chiremba wako anozozviongorora kuti asarudze kurapwa kwakanakisisa kwauri. Chiremba wako anogonawo kusangana nechikwata chevamwe vanamazvikokota kuti vakurukure nezvekurapa kwakanyanya uye uku kunonzi a Multidisciplinary timu (MDT) musangano.
Chiremba wako achafunga zvinhu zvakawanda nezve lymphoma yako uye hutano hwako hwese kuti usarudze kana, uye kuti ndechipi kurapa kunodiwa. Zvimwe zvezvavanozofunga zvinosanganisira:
- Ndeipi shanduko yakaitika (yako itsva subtype ye lymphoma)
- Nhanho ye lymphoma
- Chero zviratidzo zvauri kuwana
- Kuti lymphoma inobata sei muviri wako
- Zera rako
- Chero mamwe matambudziko ekurapa aunawo kana mishonga yauri kutora
- Zvaunofarira kana wawana ruzivo rwese rwaunoda.
Mhando dzeMarapirwo
Kushandurwa lymphoma kunoda kurapwa nenzira imwechete seyo aggressive lymphoma. Kurapa kunogona kusanganisira:
- Combination chemotherapy
- Monoclonal antibody
- Autologous stem sero rekuisa (kana hutano hwakakwana)
- Radiotherapy (kazhinji nechemotherapy)
- CAR T-cell kurapa (Chimeric antigen receptor T-cell therapy - mushure mekurapa kwekutanga kwe2)
- immunotherapy
- Targeted therapies
- Clinical kuedza kubatanidzwa
Prognosis ye Shanduko Lymphoma (TL)
Mazhinji aggressive lymphomas anogona kurapwa, kana ane nguva refu yekuregererwa mushure mekurapa. Sezvo zvakadaro, kune tariro yokuti kana wapiwa kurapwa unogona kuporeswa, kana kuva nekuregererwa kwenguva refu kubva kune yakanyanya hutsinye, yakashandurwa lymphoma. Nekudaro, iwe uchazoda kuteedzera kwepedyo mushure mekurapa kwako kuti utarise zviratidzo zvekudzokera shure.
Indolent lymphomas kazhinji haigone kuporeswa, saka kunyangwe mushure mekurapwa kweiyo lymphoma yakashandurwa, unogona kunge uchine mamwe masero eindolent lymphoma asara, uye nekudaro chiremba wako achada kutarisa izvi zvakare.
Bvunza chiremba wako kuti ndeapi mikana yaunayo yekuporeswa, kupinda mukuregererwa uye uchiri kurarama neine indolent lymphoma mushure mekurapa lymphoma yako yakashandurwa.
pfupiso
- Transformed lymphoma haiwanzoitiki, ine chete 1-3 kubva pavanhu zana vane indolent lymphoma ine shanduko gore negore.
- Kushandurwa kunowanzoonekwa kune vanhu vane indolent B-cell lymphoma, asi inogona kuitika kune vanhu vane indolent T-cell lymphoma zvakare.
- Shanduko inowanzoitika makore 3-6 mushure mekunge waonekwa kuti une indolent lymphoma, uye haiwanzoitika mushure memakore gumi nemashanu.
- Kushandurwa Lymphoma kunogona kuitika kana majini ako kana masero e-lymphoma akagadzira shanduko itsva, achichinja nzira iyo lymphoma inokura uye maitiro.
- Yakashandurwa Lymphoma yakasiyana kune indolent lymphoma "kumuka" uye kuwedzera kushanda.
- Pachine mukana wekuporeswa kubva kune yakanyanya hutsinye yakashandurwa lymphoma, asi iwe unogona kuramba uchirarama neiyo indolent lymphoma mushure mekurapa.
- Kurapa kwekushandurwa lymphoma kuchave kwakanangwa pakurapa, kana kuisa iyo aggressive lymphoma mukuregererwa.
- Taura zvese zvitsva uye zviri kuwedzera zviratidzo, kusanganisira B-zviratidzo kuna chiremba wako.
