No ka hoʻomaopopo ʻana i ka Marginal Zone Lymphoma (MZL) pono ʻoe e ʻike iki e pili ana i kāu B-Cells.
Nā ʻāpana B:
- He ʻano o ke koko keʻokeʻo
- E hakakā i ka maʻi a me ka maʻi e mālama pono iā ʻoe.
- E hoʻomanaʻo i nā maʻi i loaʻa iā ʻoe i ka wā ma mua, no laila inā loaʻa hou iā ʻoe ka maʻi like, hiki i ka ʻōnaehana pale o kou kino ke hakakā ʻoi aku ka maikaʻi a me ka wikiwiki.
- Hiki ke hele ma kāu ʻōnaehana lymphatic, i kekahi ʻāpana o kou kino e hakakā ai i ka maʻi a i ʻole ka maʻi.
- Hana ʻia i loko o kou iwi iwi (ʻo ka ʻāpana spongy i waenakonu o kou mau iwi), akā maʻamau e noho i kāu ʻōnaehana lymphatic e komo pū ana me:
- lymph aka wahi
- nā moku lymphatic a me ka wai lymph
- nā kino – ka ʻāʻī, thymus, tonsils, appendix a me nā ʻāpana o nā cell immune ma nā wahi e pili ana i nā ʻāpana o kou kino (e laʻa, nā ʻāpana peyers i loko o kou ʻōpū).
Ke loaʻa iā ʻoe ka MZL nā pūnaʻi B maʻi kanesa:
- E ulu me ke kaohi ole.
- ʻAʻole e hana maikaʻi e hakakā i nā maʻi a me nā maʻi.
- Hiki ke lilo i ʻoi aku ka nui ma mua o ka pono a hiki ke nānā aku i nā ʻokoʻa i nā pūnaʻi B olakino.
- Hiki ke ulu a ulu ka lymphoma ma kekahi wahi o kou kino.
Nā ʻano liʻiliʻi o Marginal Zone Lymphoma (MZL) - Nānā
He ʻokoʻa loa nā ʻano subtypes o MZL a ʻike ʻia kēlā me kēia a ʻokoʻa ka mālama ʻana. E kaomi i nā poʻomanaʻo ma lalo nei e ʻike i kahi hiʻohiʻona o nā ʻano subtype ʻekolu.
ʻiʻo lymphoid pili i ka mucosa (MALT) Lymphoma Zone Marginal (MZL)
Ua ʻike ʻia ʻo MALT MZL he extra-nodal lymphoma no ka mea, hoʻomaka ia ma ka ʻāpana marginal o kāu ʻiʻo lymphoid, akā ʻaʻole i loko o kāu mau lymph nodes.
It ʻO ia ke ʻano maʻamau o MZL, me kahi o 6 mai loko o 10 poʻe (60%) me MZL me kahi subtype MALT. Hiki iā ʻoe ke loaʻa i kēlā me kēia makahiki, akā maʻamau ka ulu ʻana i ka wā o kou 60 mau makahiki.
- ʻO ka mucous membrane ʻo ia ka papa palupalu, mākū, pale pale o nā pūnaewele e laina ana i nā wahi he nui o kou kino, e like me kou waha, ka ʻōpū, nā ala ea a me kekahi mau mea o loko.
- ʻiʻo lymphoid he wahi i loko o kou kino a i ʻole kekahi mau ʻōpū kahi e noho ai nā lymphocytes – e like me nā ʻōpala o Peyer i loko o kou ʻōpū.
- ʻiʻo lymphoid pili i ka mucosa (MALT) he mau pūʻulu lymphocytes i loko o kou mucosa e kōkua i ka pale ʻana iā ʻoe mai nā maʻi.
- MALT ʻo ia hoʻi kāu mau tonsils ma ke kua o kou puʻu, a me ka ʻiʻo lymphoid i hoʻopuehu ʻia a puni ke koena o kou kino, e like me kou ʻōpū, ʻāmāmā, ʻili, thyroid gland a me ka salivary glands.
MALT Marginal Zone Lymphoma (MZL) subtypes
Hiki ke hana ʻia ka MALT Marginal Zone Lymphoma (MZL) inā hōʻiliʻili nā B-lymphocytes maʻamau i loko o kāu ʻiʻo lymphoid. Hoʻohui hou ʻia ʻo MALT MZL i:
- ʻO ka ʻōpū MALT MZL, e ulu ana ma kou opu. ʻO kēia ka subtype maʻamau o MALT MZL.
- ʻAʻohe ʻōpū MALT MZL, e ulu ana i loko o ka ʻiʻo lymphoid ma waho o kou ʻōpū. He mea maʻamau ia i kou mau maka (ocular adnexa), a ukali ʻia e ka māmā a me ka salivary gland. Hiki nō hoʻi ia ma kou ʻili, thyroid a i ʻole nā wahi ʻē aʻe o kou ʻōpū a i ʻole ka ʻōpū.
He mea nui e ʻike inā loaʻa iā ʻoe ka MALT ʻōpū a i ʻole ka ʻōpū ʻole no ka mea ʻokoʻa ka mālama ʻana iā lākou. Inā ʻaʻole ʻoe maopopo i ke ʻano o MALT Marginal Zone Lymphoma (MZL) i loaʻa iā ʻoe, e ʻoluʻolu e nīnau i kāu kauka a i ʻole hui lapaʻau e wehewehe i kēia iā ʻoe.
Nā kumu pilikia no ka hoʻomohala ʻana i ka MALT Marginal Zone Lymphoma (MZL)
He mea maʻamau ka MALT MZL i ka poʻe me ka mumū lōʻihi (chronic) mai kahi maʻi a i ʻole maʻi autoimmune. He mea nui ia e ʻike, ʻo ka hapa nui o nā poʻe me kēia mau pilikia pilikia ʻaʻole e hoʻomohala i ka MZL.
Hōʻike ka papa 1 ma lalo nei i nā maʻi a me nā maʻi autoimmune e hiki ke kumu i ka MALT MZL.
1 Pūnaewele
Nā wahi o MALT lymphoma | Ke kumu paha (a i ʻole nā kumu pilikia) |
ʻO ka maʻi lymphoma MALT | ʻO Helicobacter pylori (H. pylori), he ʻano bacteria e hoʻoulu ai i ka ʻeha o ka ʻōpū. Hāʻawi ia i ka hapa nui o nā maʻi o ka ʻōpū MALT MZL. ʻO ka lapaʻau ʻana no ka ʻōpū MALT MZL e nānā i ka mālama ʻana i ka maʻi H. pylori. |
ʻAha waimaka a me ka ʻiʻo a puni ka maka (non-Gastric) | ʻO Chlamydophila psittaci (C Psittaci) kahi maʻi i hoʻopili ʻia me MALT o nā aʻa waimaka a me ka ʻiʻo o ka maka. Hoʻolaha ʻia kēia e nā manu a hiki ke hoʻoulu i ka maʻi ʻulaʻula. |
ʻili (ʻaʻohe ʻōpū) | ʻO Borrelia burgdorferi kahi maʻi i hoʻopili ʻia me MALT MZL o ka ʻili. Hoʻolaha ʻia ia e nā maʻi a hoʻoulu i ka maʻi LYME. |
ʻO ka ʻōpū liʻiliʻi (ʻaʻohe ʻōpū) | ʻO Campylobacter jejuni kahi maʻi i hoʻopili ʻia me MALT MZL o ka ʻōpū liʻiliʻi. He kumu maʻamau ia o ka ʻona ʻai. |
Nā māmā (ʻaʻohe ʻōpū) | ʻO Achromobacter xylosoxidans kahi maʻi i hoʻopili ʻia me MALT MZL o nā māmā. Hiki iā ia ke hoʻoulu i ka maʻi koko a i ʻole ka māmā o ka poʻe me nā ʻōnaehana pale haʻahaʻa. |
ʻO nā ʻāʻī koʻikoʻi (ʻaʻohe ʻōpū) | ʻO ka maʻi o Sjogren he maʻi a i ʻole kou ʻōnaehana pale ʻana i hoʻopili ʻia me MALT MZL o nā ʻōpū kohu. |
Kelepona thyroid (ʻaʻohe ʻōpū) | ʻO ka thyroiditis o Hashimoto kahi maʻi o ka ʻōnaehana pale e pili ana iā MALT MZL o ka thyroid gland. |
Nodal MZL ua kapa ʻia ʻo nodal, no ka mea, hoʻomaka ia ma ka ʻāpana marginal o kāu mau lymph nodes. ʻO ia ka subtype kakaikahi o MZL e pili ana i 1 wale nō i loko o kēlā me kēia 10 poʻe me MZL. He mea maʻamau ia i ka poʻe ma luna o 50 mau makahiki, akā naʻe, he ʻano pediatric kakaʻikahi hiki ke hoʻopilikia i nā keiki.
Hoʻomaka ka nui o nā ʻano liʻiliʻi o ka lymphoma i loko o nā puʻupuʻu lymph, no laila hiki ke paʻakikī i ka wā mua ke loaʻa i kahi hōʻailona pololei o kāu subtype.
ʻAʻole ʻike liʻiliʻi e pili ana i nā kumu o Nodal MZL. Eia nō naʻe, manaʻo ʻia ʻo ka poʻe i loaʻa i kahi maʻi autoimmune lalo, a i ʻole i loaʻa i ka maʻi viral i loko o ko lākou ate, i kapa ʻia ʻo Hepatitis C (Hep C) e ulu aʻe i ia.
Hoʻomaʻamaʻa pinepine ʻo Nodal MZL i ka mālama ʻana, akā e like me ka hapa nui o nā lymphoma molowa, hoʻi pinepine ia. Kapa ʻia kēia he relapse. ʻAʻole ia he mea maʻamau ka pono o ka mālama ʻana i hoʻokahi manawa no kāu Nodal MZL, akā maʻamau e pane maikaʻi i ka mālama ʻana a mālama ʻia ma lalo o ka mana maikaʻi.
ʻO Splenic MZL kahi subtype kakaʻikahi e hoʻomaka ana i loko o kou ʻōpū a hiki ke komo i kou koko a me kou iwi iwi. ʻO kou spleen he mea lymphatic e noho ana ma lalo o kou diaphragm. He okana ia o kou ʻōnaehana lymphatic a ʻo ia kahi e noho ai ka nui o kāu mau lymphocytes B-cell, a hana i nā antibodies. E kōkua pū ana kāu spleen e kānana i kou koko, e wāwahi ana i nā ʻulaʻula kahiko e hana i ke ala no nā sela olakino hou a me ka mālama ʻana i nā keʻokeʻo keʻokeʻo a me nā platelets, kahi e kōkua ai i kou koko e ʻā. Hiki iā ʻoe ke ʻike i kahi o kou ʻōpū ma ke kiʻi o ka ʻōnaehana lymphatic ma luna o kēia ʻaoʻao.
Hoʻopilikia ka Splenic MZL i nā pākeke ma kahi o 65 mau makahiki. He mea maʻamau ia i ka poʻe i loaʻa i ka maʻi autoimmune a i loaʻa i ka Hepatitis C – he maʻi maʻi maʻi e pili ana i kou ake. Eia naʻe, ʻaʻole nā kānaka a pau me ka splenic MZL e loaʻa kēia mau mea pilikia.
Nā hōʻailona maʻamau o Marginal Zone Lymphoma (MZL)
ʻO ka MZL ka lymphoma e ulu lohi nei, no laila ʻaʻohe ou hōʻailona i ka wā mua o kou maʻi. Aia kekahi mau hōʻailona i loaʻa iā ʻoe ma ke ʻano subtype o MZL i loaʻa iā ʻoe a ua uhi ʻia ma lalo o nā subtypes ma lalo.
Eia nō naʻe, aia kekahi mau hōʻailona e hiki ke hoʻopilikia i kekahi me ka lymphoma.
Nā hōʻailona hiki iā ʻoe ke loaʻa
Inā ʻike ʻoe i nā hōʻailona hiki iā lākou ke komo:
- ʻO nā pūnaʻi lymph pehu - he puʻupuʻu āu e ʻike ai a ʻike paha
- luhi luhi ʻole (fatiued)
- pau ka hanu
- ʻoi aku ka maʻalahi a me ke kahe ʻana ma mua o ka maʻa mau
- nā maʻi hele ʻole, a i ʻole e hoʻi mau ana (hoʻi hou)
- ka hou ʻana i ka pō ma mua o ka maʻamau
- pau ka ʻai (ʻaʻole makemake e ʻai)
- ke kaupaona ʻana me ka hoʻāʻo ʻole
- ʻili ʻili
- B-hōʻailona.
Nā hōʻailona kikoʻī o ke ʻano ʻano ʻano o ka Lymphoma Zone Marginal (MZL)
ʻO nā hōʻailona e loaʻa iā ʻoe me MALT MZL e hilinaʻi ʻia ma kahi o kou lymphoma.
ʻO ka maʻi maʻi MALT Marginal Zone Lymphoma (MZL)
Pili nā hōʻailona i kou ʻōpū a hiki ke komo:
- ʻO ka maʻi hoʻomau mau (ʻo kēia wale nō ka hōʻailona)
- ʻO kaʻehaʻeha
- Nausea (manaʻo maʻi a me he mea lā e luaʻi ana ʻoe)
- ʻO ka wai
- Pohō kaumaha (me ka manaʻo ʻole)
- Loaʻa paha i kekahi poʻe nā hōʻailona o ka anemia (ka luhi a i ʻole ka hanu ʻana) ma muli o ke kahe koko ʻana o ka ʻōpū
ʻAʻohe ʻōpū MALT Marginal Zone Lymphoma (MZL)
ʻAʻole paha ʻoe e loaʻa kekahi hōʻailona. ʻIke pinepine ʻia ka MALT MZL non-gastric i ka wā e hana ana kāu mau kauka i nā hoʻokolohua no kekahi mea ʻē aʻe. He ʻokoʻa nā hōʻailona a pili i ka ʻāpana o kou kino i hoʻopilikia ʻia. Hiki i kekahi o ʻoukou (ma kahi o ka hapalua) ke loaʻa iā MALT lymphoma ma kahi o hoʻokahi wahi o kou kino. Hiki i kēia ke hana i kahi hui o nā hōʻailona. He mea nui e haʻi aku i kāu kauka e pili ana i kāu mau hōʻailona a pau, no ka mea hiki iā ia ke kōkua iā lākou e koho i ke koho lapaʻau maikaʻi loa no ʻoe, a me ka manawa e hoʻomaka ai ka mālama ʻana.
2 Pūnaewele
Kahi wahi lymphoma MALT nodal hou | Nā hōʻailona maʻamau |
ʻO ka ʻōpū a i ʻole ka ʻōpū |
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Nā aʻa waimaka a i ʻole nā ʻiʻo a puni ka maka | Hoʻokahi maka wale nō nā hōʻailona akā ʻaʻole kakaʻikaʻi, pili paha nā maka ʻelua.
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ʻO Lun | I ka manawa pinepine, ʻaʻohe a liʻiliʻi paha nā hōʻailona akā loaʻa paha ʻoe i ka ʻu, pōkole o ka hanu, ʻaʻa koko a ʻeha ʻeha paha. |
Nūʻau salivary |
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Skin | Hiki ke hoʻololi i ka ʻili ma kahi hoʻokahi, a i ʻole ma kekahi mau wahi a puni kou kino. Hōʻike maʻamau ia ma kou mau lima, ka umauma a i ʻole ke kua me he ʻulaʻula, ʻulaʻula a poni a i ʻole nā puʻupuʻu. Loaʻa kēia mau hoʻololi i kahi manawa lōʻihi, no laila ʻaʻole ʻike nui ʻia. |
Kelepaʻi thyroid | Hiki iā ʻoe ke ʻike i kahi puʻupuʻu (pehu lymph node) ma mua o kou ʻāʻī a i ʻole he leo haʻahaʻa. Hiki iā ʻoe ke loaʻa i ka pōkole hanu a pilikia ʻoe i ka ʻai ʻana (dysphagia). Inā he haʻahaʻa kou thyroid gland, hiki iā ʻoe ke:
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Hoʻomaka pinepine ʻo Nodal MZL i kāu mau lymph nodes ma kou poʻo a me kou ʻāʻī, akā hiki ke loaʻa ma nā wahi ʻē aʻe o kou kino. Hiki i kēia ke ʻike ʻia a ʻike ʻia paha kahi puʻupuʻu i ka piha ʻana o kou lymph nodes i nā sela lymphoma maʻi kanesa, e pehu ai. Ke piʻi aʻe ka maʻi hiki ke laha i nā wahi ʻē aʻe o kou kino.
ʻO nā hōʻailona o Nodal MZL e pili pinepine i ka pehu o kāu mau lymph nodes. No laila, ʻokoʻa nā hōʻailona ma muli o kahi o kāu lymphoma, akā hiki ke komo:
- Hiki i nā pūnae lymph ma loko a kokoke paha i kou ʻāʻī ke kaomi i kou mau alaloa a i ʻole kou esophagus (hele ka meaʻai paipu mai kou waha a i ka ʻōpū). Hiki i kēia mau mea ke pilikia i ka hanu ʻana a i ʻole ka ʻai ʻana i ka nui o lākou.
- Hiki i nā pūni lymph kokoke i kou mau aʻalolo ke hoʻoulu i ka ʻeha ke kaomi ʻana o nā pūni lymph iā lākou.
- Ke ulu nei kou lymphoma a hoʻonui i ka ikehu o kou kino e ʻike paha ʻoe i nā hōʻailona B.
ʻO ka hōʻailona maʻamau o ka splenic MZL he spleen nui.
ʻO ka maʻamau, ʻaʻole hiki ke ʻike ʻia kou ʻōpū, akā inā i hoʻonui ʻia, hiki i kāu kauka ke ʻike ma lalo o kou iwi ʻaoʻao. Ke nui loa kou ʻōpū, hiki iā ia ke hoʻoikaika i kou ʻōpū i mea e māʻona ai ʻoe, ʻoiai inā ʻaʻole ʻoe i ʻai nui. Loaʻa paha iā ʻoe ka ʻeha a i ʻole ka ʻeha ma kou ʻōpū (opu).
Ke holomua nei kāu lymphoma hiki iā ʻoe ke kūkulu i nā pūnaewele lymphoma i loko o kou iwi iwi. ʻO kēia, me ka loaʻa ʻana o nā mea lymphoma he nui i loko o kou ʻōpū e hiki ke pale i kou kino mai ka hana ʻana i nā kiʻi koko hou. Hiki ke hoʻemi ʻia ka hiki o kou kino ke mālama i kou mau koko no ka hoʻohana hope ʻana. ʻO ia ke ʻano e loaʻa paha iā ʻoe nā hōʻailona pili i ke koko haʻahaʻa.
Helu koko haahaa
- ʻO ke koko keʻokeʻo haʻahaʻa - ʻO kāu mau keʻokeʻo keʻokeʻo, me kāu lymphocytes e hakakā i ka maʻi a pale iā ʻoe mai ka maʻi. Hiki i nā keʻokeʻo keʻokeʻo haʻahaʻa ke hopena i nā maʻi paʻakikī ke hoʻopau a hoʻi hou mai
- ʻO nā platelets haʻahaʻa - kōkua nā platelets i ka hoʻopaʻa ʻana i kou koko i mea e pale ai iā ʻoe mai ke kahe ʻana a i ʻole ka ʻeha nui ʻana, no laila e ʻike paha ʻoe i ke koko a i ʻole ka ʻeha ʻana.
- ʻO ke koko ʻulaʻula haʻahaʻa - lawe kou mau ʻulaʻula i ka oxygen a puni kou kino ma kahi protein i kapa ʻia he hemoglobin. Inā he haʻahaʻa kou mau koko ʻulaʻula hiki iā ʻoe ke loaʻa:
- pokole o ka hanu
- luhi - ʻo ia ka luhi nui ʻaʻole i hoʻomaikaʻi ʻia me ka hoʻomaha a me ka hiamoe
- pōniuniu
- huikau a pilikia paha ka noonoo
- ʻoi aku ka haʻalulu ma mua o ka mea maʻamau.
Nā Proteina ʻAʻole
Hiki i kekahi poʻe me ka splenic Marginal Zone Lymphoma (MZL) ke hoʻopuka i nā protein kūlohelohe i kapa ʻia ʻo cryoglobulins. Hoʻopili pū kēia mau protein i ka wā e anuanu ai ʻoe, e alakaʻi ana i:
- maikaʻi ʻole ka holo ʻana - ʻike paha ʻoe i kou manamana lima a me kou manamana wāwae i ka uliuli a i ʻole ʻoe e ʻeha a ʻeha paha
- headaches
- hilahila
- ihu ihu
- ʻike hihi ʻole.
ʻIke - Pehea e ʻike ʻia ai ʻo Marginal Zone Lymphoma (MZL).
ʻO ka hoʻomaʻamaʻa ʻana iā MZL hiki ke lawe i kekahi mau pule, a i kekahi manawa lōʻihi paha.
Inā manaʻo kāu kauka he lymphoma kou, pono lākou e hoʻonohonoho i nā hoʻokolohua koʻikoʻi. Pono kēia mau ho'āʻo e hōʻoia a hoʻopau paha i ka lymphoma ke kumu o kāu mau hōʻailona.
Nui nā ʻano ʻano like ʻole o MZL, no laila e loaʻa paha iā ʻoe nā hoʻāʻo hou e ʻike ai i kāu mea. He mea koʻikoʻi kēia no ka mea ʻokoʻa ka hoʻokele a me ka mālama ʻana i kāu subtype me nā ʻano subtype ʻē aʻe o MZL.
Pono ʻoe i hoʻokahi biopsies a ʻoi aku paha. ʻO ka biopsy kahi hana e wehe ai i kahi ʻāpana, a i ʻole nā poʻo lymph i hoʻopilikia ʻia a/ a i ʻole kahi laʻana o ka iwi iwi. Nānā ʻia ka biopsy e ka poʻe ʻepekema i loko o kahi keʻena hana e ʻike inā he mau loli e kōkua i ke kauka e ʻike i ka MZL. Aia nā ʻano biopsies:
Biopsy kumu a i ʻole ka nila maikaʻi
ʻO kēia ka hoʻokomo ʻana i kahi nila i loko o kahi puʻupuʻu lymph a i ʻole ka puʻupuʻu a me ka wehe ʻana i kahi laʻana o ka ʻiʻo. Hana ʻia me ka anaesthetic kūloko, ʻoiai ʻoe e ala ana.
Inā hohonu ka ʻōpū lymph i hoʻopili ʻia i loko o kou kino, hiki ke hana ʻia ka biopsy me ke kōkua o ke ultrasound a i ʻole ke alakaʻi x-ray kūikawā. Pono ʻoe i kahi lāʻau lapaʻau maʻamau no kēia, a e loaʻa iā ʻoe kekahi mau humuhumu ma hope.
ʻO ka biopsy node excision
Hiki i kēia ke komo i kahi ʻokiʻoki ʻoi aku i ka lā e hoʻoneʻe ai i nā ʻōpū lymph ma nā wahi ʻē aʻe o kou kino i hiki ʻole ke loaʻa ʻia e ka nila. Hana ʻia ia ma lalo o ka anaesthetic maʻamau, a e loaʻa iā ʻoe kahi ʻeha liʻiliʻi a me nā humuhumu.
Na kāu kauka e koho i ka biopsy maikaʻi loa iā ʻoe.
E loaʻa pū ʻoe i nā hoʻāʻo koko i hiki i ke kauka ke hoʻomaopopo maikaʻi i kou olakino holoʻokoʻa.
Ke kali nei i nā hualoaʻa
Manaʻo e kali i kekahi mau pule no ka loaʻa ʻana o kāu mau hoʻokolohua āpau a loaʻa hou nā hopena. Hiki ke paʻakikī kēia manawa kali, akā iHiki paha ke kōkua i ka ʻike ʻana he lymphoma palaualelo ʻo MZL, ʻaʻole e pōʻino ʻoe i ka lohi ʻana i ka mālama ʻana i kēia manawa.
E hōʻike i kāu kauka inā loaʻa iā ʻoe nā hōʻailona hou, a i ʻole e ulu aʻe ana lākou i kēia manawa. Hiki i kāu hui lapaʻau ke hāʻawi iā ʻoe i ka ʻōlelo aʻoaʻo e pili ana i ka maikaʻi o ka mālama ʻana i kāu mau hōʻailona oiai e kali ana i nā hopena.
Hiki ke kōkua i ke kamaʻilio ʻana me kekahi i kēia manawa. Inā he ʻohana a he hoaaloha paha kāu e hiki ai iā ʻoe ke kamaʻilio aku, e haʻi iā lākou i ka mea e hana nei a me kāu mea e pono ai mai lākou. Makemake pinepine ka poʻe e kōkua, akā ʻaʻole maopopo i ka mea e hana ai, a ʻaʻole makemake e hoʻokau. ʻO ka hōʻike ʻana iā lākou i kāu mea e pono ai e kōkua iā lākou a me ʻoe.
Kāhea iā mā˚ou
Hiki iā ʻoe ke kelepona i kā mākou Nurse Hotline e kamaʻilio me kekahi o kā mākou Lymphoma Care Nurses. E kaomi wale i ke pihi Hoʻokaʻaʻike iā mākou ma lalo o kēia ʻaoʻao. Hiki iā mākou ke kōkua ma ka hoʻouna ʻana iā ʻoe i ka ʻike a i ʻole ka hōʻike ʻana iā ʻoe i ke kākoʻo i loaʻa. Makemake paha ʻoe e hui pū me kekahi o kā mākou ʻaoʻao pāpaho pūnaewele e kamaʻilio me nā poʻe ʻē aʻe e noho ana me ka lymphoma.
E ʻike iā mākou ma kā mākou hui kaiaulu
Ma muli o ke ʻano subtype i manaʻo ʻia e kāu kauka, pono paha ʻoe i nā hoʻokolohua diagnostic ʻokoʻa. Kaomi ma nā poʻomanaʻo ma lalo e aʻo e pili ana i nā hoʻokolohua diagnostic no kēlā me kēia subtype.
Hoʻopili pinepine ʻia ʻo MALT MZL me kahi maʻi, no laila makemake paha kāu kauka e lawe i kahi biopsy mai ia wahi inā manaʻo lākou he maʻi kou. ʻO ia hoʻi, hiki ke hoʻohana ʻia nā ʻano hana like ʻole e lawe i ka biopsy e like me:
Gastroscopy a me ka biopsy: He biopsy o kou ʻōpū. Hoʻokomo ʻia kēia i ka hoʻokomo ʻana i kahi paipu lahilahi me ka pahupaʻikiʻi ma luna, ma kou waha a ma lalo o kāu ʻāpana digestive a i loko o kou ʻōpū. Hana ʻia ka Gastroscopy e like me ke kaʻina hana o ka lā.
Bronchoscopy a me ka biopsy: He biopsy o kou mau māmā. Me kēia kaʻina hana, hoʻokomo ʻia kahi paipu lahilahi me ke kāmela ma ka hope i loko o kou māmā. ʻO kēia ka mea e hiki ai i nā kauka ke nānā pono i ka ʻiʻo i loko o kou mau ala ea a me nā māmā, a lawe i nā laʻana. I ka hapanui o nā hihia, he hana kēia i ka lā hoʻokahi.
Hōʻike hanu: E ʻimi i kekahi mau kinoea i hiki ke hoʻoulu ʻia e nā maʻi bacteria like ʻole e like me H. Pylori. Hāʻawi ʻia ʻoe i kahi lāʻau lapaʻau a ma hope o ke kali pōkole, e noi ʻia ʻoe e hanu i loko o kahi ʻeke liʻiliʻi i hoʻohālikelike ʻia i ka baluna. A laila nānā ʻia kāu hāpana no nā kinoea e hōʻoia i kahi maʻi.
Ho'āʻo naʻau: E hōʻiliʻili ʻoe i kahi laʻana faecal (poo) a e hoʻouna ʻia i ka pathology e hoʻāʻo ai no ka maʻi H. Pylori.
ʻAʻohe hoʻāʻo hou no ka hōʻoia ʻana.
IMa waho aʻe o nā hoʻāʻo ma luna, loaʻa paha iā ʻoe ka biopsy iwi iwi e kōkua i ka hoʻomaʻamaʻa ʻana i ka splenic MZL. ʻO ia ke kumu o kekahi ʻano maʻi maʻi koko ʻē aʻe i kapa ʻia ʻo Waldenstrom's Macroglobulinemia he mau hōʻailona like loa.
Na ka iwi iwi e hāʻawi i ka ʻike e kōkua i ka hōʻoia ʻana he Splenic MZL kou lymphoma ma mua o Waldenstroms Macroglobulinemia. E hōʻike pū ana inā ua laha i kou iwi iwi. Hōʻike ʻia nā biopsies iwi iwi ma lalo o ka pauku "He aha ke ʻano o ka staging".
Ka Hoʻopaʻa ʻana a me ka Grading Marginal Zone Lymphoma (MZL)
Ke ʻike ʻia ʻoe me MZL, e nīnau hou kāu kauka e pili ana i kāu lymphoma. E komo pū ana kēia mau mea:
- He aha kāu MZL?
- He aha kāu MZL?
Kaomi ma nā poʻomanaʻo ma lalo nei e aʻo hou e pili ana i ka hoʻonohonoho ʻana a me ka hoʻopaʻa ʻana.
ʻO ka hoʻokūkū e pili ana i ka nui o kou kino i hoʻopilikia ʻia e kāu MZL a i ʻole, pehea ka lōʻihi o ka laha ʻana mai kahi i hoʻomaka mua ai.
Hiki i nā pūnae B ke hele i kekahi wahi o kou kino. 'O ia ho'i, hiki i nā pūnaewele lymphoma (nā ma'i 'a'ai B-cell), hiki ke hele i kekahi wahi o kou kino. Pono ʻoe e hoʻāʻo hou aʻe e ʻike i kēia ʻike. Kapa ʻia kēia mau hoʻokolohua he staging tests a ke loaʻa iā ʻoe nā hopena, e ʻike ʻoe inā loaʻa iā ʻoe ka pae 1 (I), pae 2 (II), pae 3 (III) a i ʻole pae 4 (IV).
Hoʻopaʻa ʻana i kāu Marginal Zone Lymphoma (MZL)
E pili ana kāu pae i:
- ʻEhia mau wahi o kou kino i loaʻa i ka lymphoma
- Aia i hea ka lymphoma - inā aia ma luna, ma lalo, a ma nā ʻaoʻao ʻelua o kāu diaphragm
- Inā ua laha ka lymphoma i kou iwi iwi a i ʻole nā ʻano ʻē aʻe, e like me kou ake, akemāmā, ʻili a iwi paha.
* ʻO kou diaphragm he ʻiʻo dome e hoʻokaʻawale i kou umauma a me kou ʻōpū.
Hana 1 | Hoʻokahi wahi puʻupuʻu lymph i hoʻopilikia ʻia, ma luna a i ʻole ma lalo o kou diaphragm* |
Kōnae 2 | ʻelua a ʻoi aʻe paha nā wahi lymph node ma ka ʻaoʻao hoʻokahi o kāu diaphragm* |
Kōnae 3 | ma ka liʻiliʻi hoʻokahi wahi lymph node ma luna a ma ka liʻiliʻi hoʻokahi wahi lymph node ma lalo o kou diaphragm* e pili ana |
Kōnae 4 | Aia ka lymphoma i loko o nā pūnana lymph he nui a ua laha i nā wahi ʻē aʻe o kou kino (e laʻa, iwi, akemāmā, ate) |
ʻIke hou e pili ana i kāu pae
Hiki i kāu kauka ke kamaʻilio e pili ana i kāu pae ma ka hoʻohana ʻana i kahi leka, e like me A, B, E, X a i ʻole S. Hāʻawi kēia mau leka i ka ʻike hou aku e pili ana i nā hōʻailona i loaʻa iā ʻoe, a i ʻole ka hopena o kou kino e ka MZL. Kōkua kēia ʻike a pau i kāu kauka e ʻimi i ka hoʻolālā lapaʻau maikaʻi loa no ʻoe.
palapala | Meaning | nui |
A a i ʻole B |
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E & X |
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S |
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Hoʻokolo ʻana
No ka ʻike ʻana i ka pae āu e loaʻa ai, e noi ʻia paha ʻoe e loaʻa i kekahi o kēia mau hoʻokolohua staging:
- ʻO ka helu helu helu (CT) scan - he scan o loko o kou umauma, ʻōpū a i ʻole pelvis.
- Positron emission tomography (PET) scan – he scan kēia o kou kino holoʻokoʻa. Hoʻopili ia i kahi nila liʻiliʻi e hoʻokomo i kahi wai e hoʻomālamalama ai nā sela lymphoma ma ke kiʻi (a i ʻole e nānā "wela"). Kōkua kēia i ka scan e kiʻi i ka wahi, ka nui a me ke ʻano o kāu lymphoma.
- Lumbar puncture – (E hoʻohana kāu kauka i ka nila e lawe i kahi laʻana o ka wai mai kahi kokoke i kou iwi kuamoʻo. Hana ʻia kēia inā pono kāu kauka e nānā inā aia kou lymphoma i loko o kou lolo a i ʻole spinal cord).
- ʻO ka biopsy iwi iwi - pili kēia i ke kau ʻana o ke kauka i ka nila ma kou kua i lalo a i loko o kou iwi ʻūhā kahi i hana ʻia ai kou mau koko. ʻElua mau laʻana a ke kauka e lawe ai i kēia kaʻina hana, me:
ʻO ka aspirate iwi iwi (BMA): lawe liʻiliʻi kēia hoʻokolohua ka wai i loaʻa i loko o ka iwi iwi.
ʻO ka iwi aspirate trepine (BMAT): liʻiliʻi kēia hoʻāʻo laana o ka iwi iwi.
Hoʻouna ʻia nā laʻana i ka pathology kahi e nānā ʻia ai nā hōʻailona o ka lymphoma.
Hiki ke ʻokoʻa ke kaʻina hana no kēia ma muli o kou wahi e noho ai a me kahi āu e mālama ai. Eia nō naʻe, e hoʻokomo pinepine ia i kahi anesthetic kūloko e hoʻopau i ka wahi.
Ma kekahi mau haukapila, hiki ke hāʻawi ʻia iā ʻoe i kahi hoʻomaha māmā e kōkua iā ʻoe e hoʻomaha, a hiki ke hoʻōki iā ʻoe mai ka hoʻomanaʻo ʻana i ke kaʻina hana. ʻAʻole paha ʻoe e pono i kēia, a loaʻa paha kahi "whistle green" e omo ai. He lāʻau hōʻeha ʻeha kēia i kapa ʻia ʻo Penthrox a i ʻole methoxyflurane, āu e hoʻohana ai i ka wā o ke kaʻina hana.
E nīnau i kāu kauka he aha nā mea i loaʻa e hōʻoluʻolu iā ʻoe i ka wā o ke kaʻina hana. Inā he nīnau kāu e pili ana i kā lākou hoʻoholo, e noi iā lākou e wehewehe i kā lākou kumu.
He ʻokoʻa ka ulu ʻana o kāu mau sela lymphoma, a ʻokoʻa ka nānā ʻana i nā cell maʻamau. ʻO ka pae o kāu lymphoma ka wikiwiki o ka ulu ʻana o kāu mau sela lymphoma, e pili ana i ko lākou nānā ʻana ma lalo o kahi microscope. ʻO nā papa he 1-4 (haʻahaʻa, waena, kiʻekiʻe). Inā loaʻa iā ʻoe kahi lymphoma papa kiʻekiʻe, ʻokoʻa loa ke ʻano o kāu mau pūnaewele lymphoma mai nā pūnaewele maʻamau, no ka mea ke ulu wikiwiki nei lākou e ulu pono. Aia ma lalo kahi ʻike o nā māka.
- G1 - papa haʻahaʻa - ke nānā aku kou mau pūnaewele i ka mea maʻamau. Ulu lākou a laha mālie.
- G2 - papa waena - ke hoʻomaka nei kāu mau kelepona e ʻokoʻa akā aia kekahi mau cell maʻamau. Ke ulu nei lākou a laha ma ka wikiwiki.
- G3 – papa kiʻekiʻe – ʻokoʻa ke ʻano o kāu mau kelepona me kekahi mau mea maʻamau. Ua ulu a laha wikiwiki.
- G4 - papa kiʻekiʻe - ʻokoʻa ke ʻano o kāu mau kelepona i ka maʻamau. Ke ulu a laha lākou i ka wikiwiki.
No ka ʻike kikoʻī e pili ana i ka diagnostics, staging and grading e ʻoluʻolu e ʻike i kā mākou ʻaoʻao pūnaewele ma aneʻi.
Ka hoʻomaopopo ʻana i kāu Marginal Zone Lymphoma (MZL) Cytogenetics
He paʻakikī loa ka Genetics, a he kumuhana i kamaʻāina ʻole i nā poʻe he nui. Aia ma lalo mākou e wehewehe i kekahi o nā genetics āu e lohe ai i ke aʻo ʻana e pili ana i kāu lymphoma. ʻAʻole pono iā ʻoe ke hoʻomaopopo pono a hoʻomanaʻo i nā mea āpau ma aneʻi. ʻO nā mea nui 4 a mākou e makemake ai e hoʻomanaʻo:
- Hiki i nā loli genetic ke kōkua i ka ulu ʻana o ka lymphoma
- aia kekahi mau genetics i ka wā e ʻike mua ʻia ai ʻoe, aʻo kekahi e ulu aʻe ma hope
- hiki ke hoʻololi i ke ʻano o ka lāʻau lapaʻau e kūpono loa iā ʻoe
- e nīnau i kāu kauka inā loaʻa iā ʻoe kekahi mau hoʻololi genetic e pili ana i kāu MZL a me kāu lapaʻau
Inā makemake ʻoe e aʻo hou aʻe, e ʻoluʻolu e heluhelu, i ʻole hiki iā ʻoe ke lele i ka ʻāpana aʻe.
E nānā nā hoʻokolohua Cytogenetics i nā loli i kāu chromosomes a i ʻole nā genes. Loaʻa iā mākou he 23 mau chromosomes, a ua helu ʻia lākou e like me ko lākou nui. He ʻokoʻa iki paha kāu mau chromosomes ke loaʻa iā ʻoe ka Marginal Zone Lymphoma (MZL).
He aha nā genes a me nā chromosomes
- He nucleus ko kēlā me kēia cell e hana ana i ko mākou kino.
- Aia i loko o ka nucleus nā 23 mau chromosomes.
- Hana ʻia kēlā me kēia chromosome mai nā kaula lōʻihi o DNA (deoxyribonucleic acid) i loko o kā mākou mau genes.
- Hana ʻia nā kaula DNA mai nā pūʻulu genes.
- Hāʻawi kā mākou mau genes i ke code e pono ai e hana i nā cell a me nā protein āpau i loko o ko mākou kino, a haʻi iā lākou pehea e nānā ai a hana paha.
- Hiki ke kapa ʻia ka hoʻololi ʻana i kāu chromosomes a i ʻole nā genes he hoʻololi genetic a i ʻole he mutation.
- Hiki i nā Lymphocytes ke lilo i lymphoma ma muli o nā hoʻololi genetic i loko o nā pūnaewele.
Hiki ke nānā ʻia kāu biopsy lymphoma e ke kauka lapaʻau kūikawā e ʻike inā loaʻa iā ʻoe nā hoʻololi gene. Inā loaʻa iā ʻoe kahi hoʻololi genetic, ʻaʻole hana pono kāu mau protein a me nā cell.
He aha nā ʻano like ʻole e hiki mai ana ma Marginal Zone Lymphoma (MZL)?
Nā unuhi
ʻO kekahi mau hoʻololi i hiki ke hana ʻia ma MZL i kapa ʻia he unuhi. ʻO kēia ka wā e haki ai kahi ʻāpana o nā chromosomes ʻokoʻa a hoʻololi i nā wahi. Inā he ʻāpana o ka ʻāpana luna pōkole o ka chromosome i unuhi ʻia, hōʻike ʻia ia me kahi (p). Inā mai ka lōʻihi, ʻo ka ʻaoʻao lalo ua hōʻike ʻia me kahi (q).
Hiki ke hoʻohui ʻia kekahi helu i kēia, e pili ana i kahi kikoʻī (a i ʻole gene) ma luna a i lalo paha. No ka laʻana, ua kapa ʻia kahi hoʻololi genetic i ʻike ʻia i kekahi poʻe me MZL t(11:18) (q21:q21).
ʻO ia hoʻi, he ʻāpana mai lalo, ʻāpana lōʻihi (q) o nā chromosomes 11 a me 18, ma ka 21st ʻāpana (a gene), ua hoʻololi i nā wahi.
ʻO kēia unuhi i kapa ʻia hoʻi he hui API-2/MALT1 no ka mea, ʻo ka gene ma ka 11th chromosome, ma ka 21st kapa ʻia ka māhele ʻo API-2, a ʻo ka gene ma ka 21st ʻāpana o ka 18th kapa ʻia ka chromosome MALT1.
Hiki ke hana ʻia nā unuhi ʻē aʻe a hahai i ke kumu o ka inoa like.
Trisomy
ʻO ka Trisomy kahi hoʻololi genetic hiki ke loaʻa ke loaʻa iā ʻoe kahi kope ʻē aʻe o kāu ʻāpana, a i ʻole kekahi o kāu mau chromosomes. Hiki iā ia ke komo i kahi kope hou o kāu 3rd, 7th, 12th a 18th chromosome. Ua kākau ʻia kēia mau hoʻololi e like me Trisomy 3, Trisomy 7, Trisomy 12 a i ʻole Trisomy 18.
moʻolelo holoi
Hiki ke holoi ʻia ke nalowale loa kekahi ʻāpana o kāu chromosomes, me nā genes ma ia ʻāpana. Me ka nalo ʻana o ke ʻano, ʻaʻole hiki i kou kino ke hahai i nā ʻōlelo a ke ʻano e hāʻawi ai - e like me ka haʻi ʻana i nā maʻi maʻi maʻi e hoʻōki i ka ulu ʻana.
ʻO kahi laʻana o kēia ke hoʻopau ʻia ka pauku luna pōkole o kāu 17th chromosome. Kapa ʻia kēia a del(17p). ʻO Chromosome 17p kahi i loaʻa ai kāu gene p53. ʻO ka p53 he gene suppressor tumor.
Nā Genes Kāohi Tumor
Hiki i nā genes suppressor tumor ke ʻike i ka wā e pōʻino ai nā cell a lilo i maʻi kanesa. Inā hiki kēia, aʻo lākou i ke kelepona e hoʻoponopono iā ia iho, a i ʻole e make - pale i ka ulu ʻana o nā maʻi maʻi me ka lymphoma.
Inā loaʻa iā ʻoe kahi del(17p), ʻaʻole i loaʻa i nā cell i poino kēlā memo e hoʻōki i ka ulu ʻana a hoʻoponopono paha iā lākou iho, no laila e hoʻomau lākou i ka ulu a hana hou i nā cell pōʻino, e hopena i ka maʻi kanesa.
Lapaʻau no Marginal Zone Lymphoma (MZL)
Nā nīnau no kāu kauka ma mua o kou hoʻomaka ʻana i ka lapaʻau
Hiki ke paʻakikī ke ʻike i nā nīnau e nīnau ai ke hoʻomaka ʻoe i ka mālama ʻana. Inā ʻaʻole ʻoe ʻike, ʻaʻole ʻoe, pehea ʻoe e ʻike ai i ka mea e nīnau ai?
ʻO ka loaʻa ʻana o ka ʻike kūpono hiki ke kōkua iā ʻoe e hōʻoluʻolu a ʻike i ka mea e manaʻo ai. Hiki iā ia ke kōkua iā ʻoe e hoʻolālā i mua no kāu mea e pono ai.
Hoʻohui mākou i kahi papa inoa o nā nīnau āu e ʻike ai he kōkua. ʻOiaʻiʻo, kū hoʻokahi ke kūlana o kēlā me kēia kanaka, no laila ʻaʻole i uhi kēia mau nīnau i nā mea āpau, akā hāʻawi lākou i kahi hoʻomaka maikaʻi.
Kaomi ma ka loulou ma lalo nei e kiʻi i kahi PDF o nā nīnau no kāu kauka.
Hoʻolālā Hoʻolālā
I ka pau ʻana o kāu mau hoʻāʻo a me kāu scans, e nānā kāu kauka iā lākou e koho i ka lāʻau lapaʻau maikaʻi loa no ʻoe. Ma kekahi mau kikowaena maʻi maʻi, e hui pū ke kauka me kahi hui o nā loea e kūkākūkā i ke koho lapaʻau maikaʻi loa. Kapa ʻia kēia a hui multidisciplinary (MDT) hui.
E noʻonoʻo kāu kauka i nā mea he nui e pili ana iā ʻoe a me kāu MZL. ʻO nā hoʻoholo i ka wā, a inā pono ʻoe e hoʻomaka i ka mālama ʻana, a ʻo ka lāʻau ʻoi aku ka maikaʻi ma muli o:
- ʻO ka subtype o MZL iā ʻoe.
- ʻO kāu pae pākahi o MZL, nā hoʻololi genetic a me nā hōʻailona.
- ʻEhia kou mau makahiki a me kou mōʻaukala olakino a me ke olakino maʻamau.
- ʻO kou ola kino a noʻonoʻo i kēia manawa.
- ʻO kēlā me kēia makemake āu e mālama ai ma hope o ka haʻi ʻia ʻana e pili ana i kāu mau koho.
Nā hoʻāʻo ʻē aʻe āu e pono ai
Hiki ke kauoha ʻia nā hoʻāʻo hou aʻe ma mua o kou hoʻomaka ʻana i ka mālama ʻana i mea e hiki ai i kou puʻuwai, nā māmā a me nā puʻupaʻa ke hoʻokō i ka lāʻau lapaʻau. Hiki i kēia mau mea ke komo i ka ECG (electrocardiogram), ka hoʻāʻo ʻana o ka māmā a i ʻole ka hōʻiliʻili mimi 24-hola.
Hiki i kāu kauka a kahu maʻi maʻi ke wehewehe i kāu hoʻolālā lapaʻau a me nā hopena ʻaoʻao iā ʻoe. Hiki iā lākou ke pane i nā nīnau āu e loaʻa ai. He mea nui ʻoe e nīnau iā lākou i nā nīnau e pili ana i kekahi mea āu i hoʻomaopopo ʻole ai a hopohopo paha.
Nā ʻano lapaʻau
Aia ma lalo iho kahi hiʻohiʻona o nā ʻano lapaʻau like ʻole. Inā makemake ʻoe i ka ʻike kikoʻī hou aku, e ʻoluʻolu e ʻike i kā mākou ʻaoʻao pūnaewele lapaʻau ma aneʻi.
Hiki i nā koho lapaʻau ke komo i kekahi o kēia mau mea:
Nānā a kali (ka nānā ʻana)
ʻAʻole pono paha ka nui o ka poʻe me MZL i ka mālama koke ʻana, a i ʻole. ʻO ke kiaʻi a kali ka manawa e nānā pono ʻia ai ʻoe e kāu hui lapaʻau, akā ʻaʻole pono e mālama. He ala maikaʻi loa kēia inā paʻa kou maʻi, a ʻaʻole e hoʻomaka i nā hōʻailona hopohopo. Hiki i ka MZL ke paʻa me ka liʻiliʻi, ʻaʻohe hōʻailona no nā mahina a i ʻole mau makahiki. E nānā ikaika ana kāu hui lapaʻau iā ʻoe me nā koho a me nā hoʻokolohua maʻamau, no laila hiki iā lākou ke ʻike i ka wā mua, inā pono ʻoe e hoʻomaka i ka lapaʻau. Hoʻohana maikaʻi ʻia kēia ala me nā lymphoma molowa.
Mālama Kākoʻo
Kōkua ka mālama kākoʻo iā ʻoe e hoʻokō maikaʻi i kāu maʻi, nā lāʻau lapaʻau a me nā hopohopo. Hiki ke komo:
- ka hāʻawi ʻana i nā lāʻau lapaʻau e mālama i nā hopena ʻaoʻao.
- kōkua iā ʻoe i ka hoʻolālā ʻana i kāu mau pono mālama olakino.
- kōkua e kōkua iā ʻoe e ola maikaʻi me kāu lymphoma.
- kōkua iā ʻoe e komo i kāu mau kuleana super a i ʻole Centrelink.
- kākoʻo i kāu ʻōnaehana pale me nā lāʻau lapaʻau e like me Intragam (antibodies) a i ʻole nā lāʻau lapaʻau. ʻAʻole palekana a maikaʻi paha nā lāʻau lapaʻau a pau ke mālama ʻoe, no laila e ʻoluʻolu e kamaʻilio me kāu hui lapaʻau ma mua o ka loaʻa ʻana o kekahi mau lāʻau lapaʻau.
Nā ʻOihana Ola Ola like ʻole e hāʻawi i ka mālama kākoʻo
- kāu kauka lapaʻau kūloko (GP)
- kanaka hana kaiaulu
- physiotherapist
- nā mea hoʻoponopono hana
- psychologist a i ʻole kākāʻōlelo
- hui mālama palliative
- hui mālama haematology/oncology.
Ma muli o kahi āu e mālama ai, aia paha nā lawelawe like ʻole. E nīnau i kāu kahu hānai a kauka paha e pili ana i ka mālama kākoʻo i loaʻa iā ʻoe.
Ka lāʻau lapaʻau (Radiotherapy)
Hoʻohana ka radiotherapy i ka radiation e pepehi i nā maʻi kanesa. Ua like ia me nā kukui X ikaika nui a hana ʻia i kēlā me kēia lā, maʻamau mai ka Pōʻakahi a hiki i ka Pōʻalima no kekahi mau pule. Hiki ke ho'ohana 'ia no ka ho'ōla 'ana i ka ma'i 'a'ai 'ana, ke kōkua 'ana i ke kala 'ana, a i 'ole ka mālama 'ana i kekahi mau hō'ailona.
Antibiotics
Hiki ke mālama 'ia kekahi mau lymphoma MALT me nā lā'au'alopelo no ka mea, ho'opau pinepine ka lymphoma i ka ulu 'ana ke mālama 'ia ka ma'i. He mea maʻamau kēia i ka MALT ʻōpū i hoʻokumu ʻia e nā maʻi H. pylori, a i ʻole no nā MALT non-gastric kahi maʻi i loko a puni ka maka.
Ho'āla
Hiki ke hoʻohana ʻia ke ʻokiʻoki e wehe i ka lymphoma holoʻokoʻa. Pono paha kēia inā loaʻa iā ʻoe ka lymphoma splenic e wehe i kou ʻōpū holoʻokoʻa. Kapa ʻia kēia ʻoki ʻana he splenectomy. Hiki iā ʻoe ke hāʻawi ʻia i kahi ʻokiʻoki inā loaʻa iā ʻoe kekahi ʻano subtype o MZL a aia ka lymphoma i hoʻokahi wahi liʻiliʻi o kou kino.
Kemohana (kemo)
Hiki ke hāʻawi ʻia ke kemo ma ke ʻano he papa a/a i ʻole e hāʻawi ʻia ma ke ʻano he kulu (infusion) i loko o kou vein (i loko o kou kahawai koko) ma ke keʻena maʻi maʻi a i ʻole ka haukapila. Hiki ke hui pū ʻia kekahi mau lāʻau chemo like ʻole me kekahi lāʻau lapaʻau ʻē aʻe. Hoʻopau ʻo Chemo i ka ulu wikiwiki ʻana o nā maʻi maʻi maʻi, akā hiki ke hoʻopilikia i kāu mau sela maikaʻi e ulu wikiwiki ana, e hana ana i nā hopena ʻaoʻao.
ʻAi kino monoclonal (MAB)
Loaʻa paha iā ʻoe kahi infusion MAB ma ke keʻena maʻi maʻi a i ʻole ka haukapila. Hoʻopili ʻo MAB i ka cell lymphoma a huki i nā maʻi ʻē aʻe e hakakā ana i nā keʻokeʻo keʻokeʻo a me nā protein i ke kanesa. Kōkua kēia i kāu ʻōnaehana pale ʻana i ka MZL.
Kemo-immunotherapy
Hoʻohui ʻia ka chemotherapy me kahi antibody monoclonal (no ka laʻana, rituximab).
Hoʻoponoponoʻia ka hopena
Hiki iā ʻoe ke lawe i kēia mau mea ma ke ʻano he papa a infusion paha i loko o kou vein. Hiki ke lawe ʻia nā lāʻau lapaʻau waha ma ka home, ʻoiai e koi ana kekahi i kahi noho maʻi pōkole. Inā loaʻa iā ʻoe kahi infusion, hiki iā ʻoe ke loaʻa ia ma ka lā keʻena lapaʻau a i ʻole ma ka haukapila. Hoʻopili ʻia nā lāʻau lapaʻau i hoʻopaʻa ʻia i ka cell lymphoma a me nā hōʻailona poloka e pono ai e ulu a hoʻohua hou i nā cell. Hoʻopau kēia i ka ulu ʻana o ka maʻi maʻi, a make nā pūnaewele lymphoma.
Ka hoʻololi ʻana o ke kino-kelepona (SCT) / Hoʻololi ʻia ka iwi iwi
Inā ua lapaʻau mua ʻia ʻoe a hoʻi hou i ka manawa pōkole, hiki ke hāʻawi ʻia iā ʻoe i kahi transplant-cell transplant (nā mākua a me nā keiki), a i ʻole ke kanu ʻana i ka iwi iwi (keiki). Akā naʻe, ʻaʻole kēia he koho kūpono no kēlā me kēia. He mau kaʻina hana paʻakikī kēia a hiki iā ʻoe ke ʻike i ka ʻike hou aku ma luna o lākou ʻaneʻi.
Laina Laina Mua
Hoʻomaka i ka lāʻau lapaʻau
ʻAʻole pono ʻoe i ka lāʻau lapaʻau ke ʻike mua ʻia ʻoe me MZL. Akā, hiki iā ʻoe ke hele e kiaʻi a kali. He mea maʻamau kēia no ka poʻe me ka maʻi pae 1 a i ʻole 2, a ʻo kekahi poʻe me ka maʻi pae 3 inā paʻa a ʻaʻole e hōʻike iā ʻoe i nā hōʻailona.
I kekahi mau hihia, e hoʻomaka ʻoe i ka mālama ʻana. He koho paha ka lapaʻau iā ʻoe inā loaʻa iā ʻoe kahi pae kiʻekiʻe MZL, ke ʻike nei i nā hōʻailona a i ʻole ka hoʻomaka ʻana o kou maʻi ma hope o ke kiaʻi ʻana a kali. Ke hoʻomaka ʻoe i ka mālama ʻana no ka manawa mua, ua kapa ʻia ʻo ia ka lāʻau lapaʻau mua.
Inā ʻike ʻoe i ka inoa o ka lāʻau lapaʻau āu e loaʻa ai, hiki iā ʻoe ke loaʻa ʻike hou aʻe ma aneʻi.
ʻO ka maʻi maʻi MALT Marginal Zone Lymphoma (MZL)
E manaʻoʻiʻo a ʻaʻole paha, ʻo ka lāʻau lapaʻau maʻamau maʻamau no Gastric MALT MZL he lāʻau antibiotic. ʻO kēia ke kumu no ka maʻi bacteria (H. pylori). Ma ka wehe 'ana i ka H. pylori, ua ho'ōla 'ia ka MALT MZL. Eia nō naʻe, ʻo H. Pylori he maʻi maʻi paʻakikī paʻakikī, a hiki ke paʻakikī ke hoʻopau ʻia. Pono ʻoe i ka hui pū ʻana o nā lāʻau antibiotic i nā pule he nui e hoʻopau i ka H. Pylori.
Loaʻa paha iā ʻoe kekahi ʻano lāʻau lapaʻau i kapa ʻia ʻo ka mea hoʻopaʻa paʻa proton. ʻO nā hiʻohiʻona o nā mea hoʻopaʻapaʻa proton pump he pantoprazole, omeprazole a me esomeprazole. Hāʻawi ʻia kēia mau mea e kōkua i ka hoʻoponopono ʻana i nā maʻi ʻōpū a i ʻole reflux i loaʻa iā ʻoe mai ka maʻi.
Hiki ke lōʻihi, a he mau makahiki paha no ka nalo ʻana o ka lymphoma ma hope o ka lāʻau antibiotic. Eia naʻe, me ka hala ʻana o ka maʻi ʻaʻole pono e ulu ka lymphoma i kēlā manawa, a ʻaʻole pono ʻoe i kahi lapaʻau hou. E hele paha ʻoe e nānā a kali i hiki i kāu hui lapaʻau ke nānā i kāu holomua.
Nā koho lapaʻau ʻē aʻe e hāʻawi ʻia iā ʻoe
- Nānā a kali (ka nānā ʻana)
- Ka lāʻau lapaʻau (Radiotherapy)
- Ho'āla
- Monoclonal Antibody (MAB) - rituximab, me ka chemotherapy a i ʻole
- Kemo-immunotherapy
- Hiki i nā hoʻokolohua lapaʻau inā kūpono - e kamaʻilio me kāu hui lapaʻau e pili ana i nā hoʻokolohua lapaʻau i loaʻa.
ʻAʻohe ʻōpū MALT Marginal Zone Lymphoma (MZL)
- Antibiotic - inā pili ka lymphoma i kou mau maka
- Nānā a kali (ka nānā ʻana)
- ʻO ka ʻoki ʻana - inā pili wale ka lymphoma i hoʻokahi ʻāpana o kou kino e like me ke akemāmā a i ʻole ka umauma
- Ka lāʻau lapaʻau (Radiotherapy)
- Kemohana (kemo)
- ʻAi kino monoclonal (MAB)
- Kemo-immunotherapy
- Hiki i nā hoʻokolohua lapaʻau inā kūpono - e kamaʻilio me kāu hui lapaʻau e pili ana i nā hoʻokolohua lapaʻau i loaʻa.
Anuu mua
- Nānā a kali (ka nānā ʻana)
- Ka lāʻau lapaʻau (Radiotherapy)
- Hiki i nā hoʻokolohua lapaʻau inā kūpono - e kamaʻilio me kāu hui lapaʻau e pili ana i nā hoʻokolohua lapaʻau i loaʻa
ʻIa pae kiʻekiʻe
- Kemohana (kemo)
- ʻAi kino monoclonal (MAB)
- Kemo-immunotherapy
- Hiki i nā hoʻokolohua lapaʻau inā kūpono - e kamaʻilio me kāu hui lapaʻau e pili ana i nā hoʻokolohua lapaʻau i loaʻa
- Nānā a kali (ka nānā ʻana)
- Ka lāʻau lapaʻau (Radiotherapy)
- Kemohana (kemo)
- ʻAi kino monoclonal (MAB)
- Kemo-immunotherapy
- Hiki i nā hoʻokolohua lapaʻau inā kūpono - e kamaʻilio me kāu hui lapaʻau e pili ana i nā hoʻokolohua lapaʻau i loaʻa
Laina Lua a me ka hoomau ana
He aha ka hana ke hoʻi hou ʻoe?
Ma hope o ka lapaʻau ʻana e hele paha ʻoe i ke kala ʻana. ʻO ke kala ʻana kahi manawa i koe ʻole ai nā hōʻailona o ka MZL i loko o kou kino, a i ʻole ke hoʻomalu ʻia ka MZL a ʻaʻole pono e mālama ʻia. Hiki ke hoʻomau ʻia ke kala ʻana no nā makahiki he nui, akā i ka hopena, hoʻi mai ka MZL (hoʻi hou). Ma muli o ka lōʻihi o kou kala ʻana, hiki ke hāʻawi hou ʻia iā ʻoe ka lāʻau like ʻole, a i ʻole kahi lapaʻau ʻē aʻe.
ʻO Lymphoma ʻĀpana Marginal Refractory (MZL)
I nā hihia koʻikoʻi, ʻaʻole hiki iā ʻoe ke loaʻa ke kala me ka lāʻau lapaʻau mua. Ke hana ʻia kēia, kapa ʻia kāu MZL "refractory". Inā loaʻa iā ʻoe ka refractory MZL e hāʻawi kāu kauka i kahi lāʻau lapaʻau ʻē aʻe.
ʻO ka lāʻau lapaʻau no ka lymphoma hou ʻana a i ʻole refractory i kapa ʻia ka lāʻau lapaʻau lua. ʻO ka pahuhopu o ka lāʻau lapaʻau ʻelua e hoʻihoʻi hou iā ʻoe i ke kala ʻana.
Inā loaʻa iā ʻoe ke kala hou aʻe, a laila hoʻi hou a loaʻa hou ka lāʻau lapaʻau, ua kapa ʻia kēia mau lāʻau lapaʻau e hiki mai ana i ka lāʻau lapaʻau ʻekolu, ka lāʻau lapaʻau ʻehā a pēlā aku.
Hiki ke hana hou kēia ʻano i nā makahiki he nui.
Kaomi ma nā poʻomanaʻo ma lalo nei e aʻo i nā lāʻau lapaʻau lua e hāʻawi ʻia iā ʻoe.
- E nānā a kali
- Antibiotics
- Ke kalawela
- ʻAi kino monoclonal (MAB)
- Chemotherapy
- ʻO Chemoimmunotherapy
- ʻO ka lāʻau lapaʻau i hoʻopaʻa ʻia (e like me zanubrutinib inā ua loaʻa iā ʻoe ka CD20+ e hoʻopaʻa ʻia ana i ka lāʻau lapaʻau, e like me rituximab a i ʻole obinutuzumab)
- Hiki i nā hoʻokolohua lapaʻau inā kūpono - e kamaʻilio me kāu hui lapaʻau e pili ana i nā hoʻokolohua lapaʻau i loaʻa.
- Nānā a kali (ka nānā ʻana)
- Kemohana (kemo)
- ʻAi kino monoclonal (MAB)
- Kemo-immunotherapy
- ʻO ka lāʻau lapaʻau i hoʻopaʻa ʻia (e like me zanubrutinib inā ua loaʻa iā ʻoe ka CD20+ e hoʻopaʻa ʻia ana i ka lāʻau lapaʻau, e like me rituximab a i ʻole obinutuzumab)
- Ka hoʻololi ʻana o ke kino-kelepona (SCT)
- Hiki i nā hoʻokolohua lapaʻau inā kūpono - e kamaʻilio me kāu hui lapaʻau e pili ana i nā hoʻokolohua lapaʻau i loaʻa.
- Nānā a kali (ka nānā ʻana)
- Splenectomy - ʻokiʻoki
- Kemohana (kemo)
- ʻAi kino monoclonal (MAB)
- Kemo-immunotherapy
- ʻO ka lāʻau lapaʻau i hoʻopaʻa ʻia (e like me zanubrutinib inā ua loaʻa iā ʻoe ka CD20+ e hoʻopaʻa ʻia ana i ka lāʻau lapaʻau, e like me rituximab a i ʻole obinutuzumab)
- Ka hoʻololi ʻana o ke kino-kelepona (SCT)
- Hiki i nā hoʻokolohua lapaʻau inā kūpono - e kamaʻilio me kāu hui lapaʻau e pili ana i nā hoʻokolohua lapaʻau i loaʻa.
Nā hopena ʻaoʻao o ka Marginal Zone Lymphoma (MZL) lapaʻau
Nui nā hopena ʻaoʻao o ka lāʻau lapaʻau a ke hilinaʻi nei lākou i ka lāʻau i hāʻawi ʻia. Hiki i ke kauka lapaʻau a/a i ʻole kahu maʻi maʻi ke wehewehe i nā hopena ʻaoʻao kikoʻī ma mua o kāu mālama ʻana.
ʻO kekahi o nā hopena ʻaoʻao maʻamau o ka lymphoma a me kāna mālama ʻana he helu koko haʻahaʻa. Hāʻawi ka papa ma lalo i kahi ʻike ma luna o kēia mau koko a me nā hōʻailona.
Keʻokeʻo keʻokeʻo | ʻulaʻula | Nā Kauliana | |
Inoa Lapaau | Neutrophils & Lymphocytes | ʻErythrocytes | Nā Kauliana |
He aha kā lākou hana? | Kaua i ka ma'i ma'i | Lawe i ka oxygen | Uoki ke kahe ʻana |
He aha ke ʻano o ka hemahema? | Neutropenia a me lymphopenia | Anemia | ʻO ka Thrombocytopenia |
Pehea e pili ai kēia i koʻu kino? | E loaʻa iā ʻoe nā maʻi hou aʻe a paʻakikī paha ke hoʻopau iā lākou ʻoiai me ka lawe ʻana i nā lāʻau antibiotic. | Hiki paha iā ʻoe ke haʻalulu ka ʻili, luhi, hanu ʻole, ke anu a me ka poni. | Hiki iā ʻoe ke ʻeha maʻalahi, a i ʻole ke koko ʻaʻole e pau koke ke ʻoki ʻoe. |
He aha kaʻu hui lapaʻau e hoʻoponopono ai i kēia? |
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If a pau ua haʻahaʻa kou mau koko koko i kapa ʻia kēia 'pancytopenia'. YPono paha ʻoe e hele i ka haukapila no ka mālama ʻana e kōkua i ka hoʻomaikaʻi ʻana i kou pae helu koko.
Nā hopena maʻamau ʻē aʻe o ka Marginal Zone Lymphoma (MZL) lapaʻau
- Ka maʻi i loko o ka ʻōpū (nausea) a/a i ʻole ka luaʻi ʻana.
- ʻEha waha (mucositis). Hiki paha iā ʻoe ke ʻike i ka loli o ka ʻono o ka meaʻai a me nā mea inu.
- ʻO nā pilikia o ka ʻōpū e like me ka constipation a i ʻole ka maʻi maʻi.
- ʻO ka luhi a i ʻole ka nele o ka ikehu ʻaʻole i kōkua ʻia e ka hoʻomaha a i ʻole ka hiamoe (ka luhi).
- ʻEha ʻeha a me ka ʻeha (myalgia).
- ʻEha a me ka ʻeha o ka hui (arthralgia).
- ʻO ka lauoho lauoho a / a i ʻole ka lahilahi (alopecia).
- Ka noʻonoʻo a me ka paʻakikī i ka hoʻomanaʻo ʻana i nā mea (ka lolo chemo).
- Hoʻololi ka manaʻo i kou mau lima a me kou mau wāwae e like me ke kani ʻana, nā pine a me nā nila a i ʻole ka ʻeha (neuropathy).
- Hoʻemi ʻia ka momona a i ʻole ka menopause mua (hoʻololi o ke ola).
No ka ʻike hou aku e pili ana i nā hopena ʻaoʻao kikoʻī a pehea ʻoe e hoʻokele ai iā lākou, kaomi ma ka pihi ma lalo.
Nā ho'āʻo hoʻokolohua
Nui nā koho lapaʻau e hoʻāʻo ʻia i nā hoʻokolohua lapaʻau a puni ka honua no nā maʻi me MZL. mākou ʻōlelo aku ʻoe i kēlā me kēia manawa e pono ai ʻoe e hoʻomaka i nā lāʻau lapaʻau hou, e nīnau ʻoe i kāu kauka e pili ana i nā hoʻokolohua lapaʻau e hiki ai iā ʻoe ke kūpono.
He mea nui nā hoʻokolohua lapaʻau no ka loaʻa ʻana o nā lāʻau lapaʻau hou, a i ʻole nā hui pū ʻana o nā lāʻau e hoʻomaikaʻi ai i ka mālama ʻana iā MZL i ka wā e hiki mai ana.
Hiki iā lākou ke hāʻawi iā ʻoe i kahi manawa e hoʻāʻo ai i kahi lāʻau hou, hui pū ʻana o nā lāʻau lapaʻau a i ʻole nā lāʻau lapaʻau ʻē aʻe āu e hiki ʻole ke loaʻa ma waho o ka hoʻokolokolo. Inā makemake ʻoe e komo i kahi hoʻokolohua lapaʻau, e nīnau i kāu kauka i nā hoʻokolohua lapaʻau āu e kūpono ai.
No ka ʻike hou aku e pili ana i nā hoʻokolohua lapaʻau, e ʻoluʻolu e heluhelu i kā mākou 'Ka hoʻomaopopo ʻana i nā hoʻokolohua lapaʻau ' pepa ʻoiaʻiʻo a kipa paha i kā mākou webpage.
Ka wānana a me ke ola ʻana - Noho me Marginal Zone Lymphoma (MZL)
Hōʻikeʻike
Hōʻike ka wānana i ke ʻano o kāu MZL e hana ai, a pane aku i ka mālama ʻana. ʻO ka hapa nui o nā lymphoma molowa, me ka MZL e ulu mālie i ka manawa lōʻihi. Hoʻomaʻamaʻa maikaʻi lākou i ka mālama ʻana, akā ʻaʻole hiki ke hoʻōla. Eia naʻe, nui ka poʻe e ola maikaʻi me ka ʻole o nā hōʻailona no ka manawa lōʻihi. Loaʻa ka manawa kūpono e ola ai ʻoe i kahi ola maʻamau.
ʻO kāu wānana ponoʻī he mea hoʻokahi a noʻonoʻo i nā mea he nui e like me kou mau makahiki, ke olakino holoʻokoʻa, genetics, pane i nā lāʻau lapaʻau a me ke komo ʻana i ka mālama.
E nīnau i kāu kauka e pili ana i kāu wānana ponoʻī a me nā mea a lākou e manaʻo ai e loaʻa iā ʻoe mai kāu mau lapaʻau.
Ola - Noho me ke kanesa
ʻO ke ola ola e pili ana i ka poʻe i loaʻa i ka maʻi kanesa i kēlā me kēia manawa o ko lākou ola. Hoʻomaka ia i ka manawa e ʻike ʻia ai ʻoe a hoʻomau i kou ola. ʻO ka pahuhopu o ke ola ʻana i ka lymphoma, ʻo ia ka hōʻoia e ola ʻoe me ka maikaʻi o ke ola.
ʻO ke ola olakino, a i ʻole kekahi mau hoʻololi ʻana i ke ʻano o ka nohona ma hope o ka mālama ʻana he mea kōkua nui ia i kou ola hou ʻana. Nui nā mea hiki iā ʻoe ke hana e ola maikaʻi me MZL. Loaʻa iā mākou nā ʻike kikoʻī me ka ʻike pono e pili ana i ke ola maikaʻi me ka lymphoma. Aia nā loulou i kēia ma lalo o kēia ʻāpana.
He nui ka poʻe i ʻike ma hope o ka hōʻoia ʻana i ka maʻi maʻi a i ʻole ka mālama ʻana e loli ana kā lākou mau pahuhopu a me nā mea nui i ke ola. ʻO ka ʻike ʻana i ke ʻano o kāu 'mea maʻamau hou', hiki ke hoʻolōʻihi i ka manawa a me ka paʻakikī. He ʻokoʻa paha nā manaʻolana o kou ʻohana a me kou mau hoaaloha. Hiki paha iā ʻoe ke kaʻawale, luhi a i ʻole kekahi mau manaʻo like ʻole e loli i kēlā me kēia lā.
Pahuhopu nui o ke ola
ʻO nā pahuhopu nui o ke ola ʻana ke kōkua iā ʻoe:
- e ʻeleu i kāu hana, ʻohana, a me nā kuleana ola ʻē aʻe.
- e hoʻemi i nā hopena ʻaoʻao a me nā hōʻailona o ka maʻi kanesa a me ka mālama ʻana.
- ʻike a mālama i nā hopena hope loa.
- kōkua iā ʻoe e kūʻokoʻa e like me ka hiki.
- hoʻomaikaʻi i kou maikaʻi o ke ola a mālama i ke olakino noʻonoʻo maikaʻi.
Hoʻoponopono i ke kanesa
Hiki ke hāʻawi ʻia iā ʻoe nā ʻano hoʻolaʻa maʻi kanesa. Hiki i kēia ke manaʻo i kekahi o ka laulā ākea o na lawelawe e like me:
- hoʻomaʻamaʻa kino no ka mālama ʻana i ka ʻeha a i ʻole e hoʻomaikaʻi i kāu neʻe.
- meaʻai a me ka hoʻolālā hoʻoikaika kino.
- ka manaʻo, ka ʻoihana a me ke aʻo kālā.
Loaʻa iā mākou kekahi mau ʻōlelo aʻoaʻo maikaʻi no ka noho maikaʻi ʻana me ka lymphoma ma kā mākou pepa ʻike ma lalo nei:
- Makaʻu i ka hoʻi hou ʻana o ka maʻi kanesa a me ka hopohopo scan
- Ka mālama moe a me ka lymphoma
- Hoʻoikaika kino a me ka lymphoma
- Ka luhi a me ka lymphoma
- ʻO ka moekolohe a me ka pilina
- Ka hopena noʻonoʻo o ka maʻi lymphoma a me ka mālama ʻana
- Ka hopena manaʻo o ka noho ʻana me ka lymphoma
- Ka hopena noʻonoʻo o ka lymphoma ma hope o ka hoʻopau ʻana i ka mālama lymphoma
- Ka mālama ʻana i kekahi me Lymphoma
- Ka hopena noʻonoʻo o ka lymphoma hou a i ʻole refractory
- Nā lāʻau lapaʻau hoʻohui a me nā mea ʻē aʻe: Lymphoma
- Ka mālama ponoʻī a me ka Lymphoma
- Mea ai a me Lymphoma
Lymphoma i hoololiia
ʻO Lymphoma i hoʻololi ʻia i ka wā e hoʻololi ai ka lymphoma molowa - ulu mālie a "hoʻololi" i loko o kahi lymphoma ikaika a ulu wikiwiki paha. He mea kakaikahi loa kēia me MZL, aia ma lalo o 1 kanaka no kēlā me kēia 100,000 poʻe me MZL. Inā hoʻololi kāu MZL, hiki iā ʻoe ke loaʻa ka ʻike hou aku ma lymphoma i hoololiia maanei.
