Lymphoma Australia idachita bwino polandira thandizo lapadziko lonse kuchokera kwa AbbVie kuti achite zoyankhulana ndi akatswiri aku Australia komanso apadziko lonse lapansi a lymphoma and chronic lymphocytic leukemia (CLL). Zofunsazo zifotokoza zaposachedwa kwambiri za mayeso azachipatala a lymphoma/CLL ndi maphunziro ochokera padziko lonse lapansi ndipo zidaperekedwa pamsonkhano wa ASH. Zoyankhulana izi zidzagawidwa padziko lonse lapansi kudzera m'magulu olimbikitsa odwala.
Lymphoma Australia idachita zoyankhulana pafupifupi 40 m'masiku 4 a msonkhano ndipo tikufuna kupereka zikomo kuchokera pansi pamtima kuchokera ku gulu la lymphoma / CLL kwa aliyense amene adagawana nafe nthawi, chidziwitso ndi ukatswiri wawo.
B-cell Lymphoma
Dr Laurie Sehn - Zosintha za ASH Lymphoma.
Dr Laurie Sehn wochokera ku British Columbia Cancer Center wochokera ku Vancouver, Canada ndi Wapampando wa bungwe la alangizi azachipatala la International Lymphoma Coalition. Dr Sehn adakambilana zina mwazabwino kwambiri muzamankhwala omwe adaperekedwa pamsonkhano wa ASH wa lymphoma. Izi zinaphatikizapo Polatuzumab (antibody drug conjugate) yofalitsa B-cell lymphoma (DLBCL) ndi Mosunetuzumab - (bispecific antibody) yogwiritsidwa ntchito pa B-cell non-Hodgkin lymphomas.Dr Chan Cheah - Phase I Study TG-1701 Relapsed or Refractory B-cell Lymphoma.
A/Prof Chan Cheah, Consultant Haematologist, Sir Charles Gairdner Hospital, Hollywood Private Hospital & Blood Cancer Research WA, ku Perth, Western Australia, adakambirana za chiwonetsero chazithunzi pa ASH cha kuyesa komwe kunachitika ku Australia pogwiritsa ntchito m'badwo watsopano wa Bruton's Tyrosine Kinase. (BTK) inhibitor yotchedwa TG-1701 yomwe imagwiritsidwa ntchito kwa odwala omwe abwereranso / refractor B-cell malignancies. Mankhwala apakamwawa amaperekedwa ngati wothandizira m'modzi kuphatikiza umbralisib (PI3K inhibitor) ndi ubiltuximab (glycoengineered anti-CD20 monoclonal antibody).Dr George Akutsatira - Zosintha za Lymphoma.
Dr George Follows ndi Lymphoma/CLL Clinical Lead ku Cambridge ndipo amakhala ndi maudindo angapo kuphatikiza wapampando wa UK CLL forum. Dr Follows anakambirana za zosintha za lymphoma zomwe zaperekedwa pa msonkhano wa chidwi wa ASH. Izi zikuphatikizapo kuyesa kwa gawo loyamba pogwiritsa ntchito mankhwala atsopano otchedwa Monunetuzumab omwe ndi bispecific monoclonal antibody yomwe imayang'ana CD3 ndi CD20 ndipo zachititsa kuti odwala omwe ali ndi B-cell non-Hodgkin lymphoma abwererenso kapena osasintha, kuphatikizapo odwala omwe adabwerera ku CAR T. - cell mankhwala.
Dr Stephen Schuste - Mosunetuzumab imapangitsa kuti odwala omwe ali ndi B-cell non-Hodgkin lymphoma apulumuke.
Bispecific monoclonal antibody Mosunetuzumab, yomwe imayang'ana CD3 ndi CD20, idatsogolera kuyankha kwanthawi yayitali kwa odwala omwe ali ndi B-cell non-Hodgkin lymphoma (NHL), ngakhale omwe anali ndi matenda omwe adayambiranso kapena kukana chimeric antigen receptor (CAR) T- ma cell therapy. Dr Schuste akukambirana za kafukufuku wa gawo la I/Ib (GO29781; NCT02500407) wa mosunetuzumab mwa odwala omwe ali ndi B-cell non-Hodgkin lymphoma (NHL), omwe abwereranso / kukana (R/R) kumankhwala a CAR-T kapena omwe kuchedwetsa chithandizo chogwira ntchito sikuphatikiza njira iyi. Thandizo loyambirira la deta kuti mosunetuzumab ili ndi mphamvu yolekerera komanso yokhazikika mu R/R B-cell NHL yokonzedweratu.
Dr John Leonard - zowunikira pamisonkhano ya lymphoma.
Dr Leonard adakambirana za akatswiri ake pazowonetsa za lymphoma pamsonkhano. Anakambilana mitu ingapo yomwe inali: • Follicular lymphoma – chemo free regimens • Diffuse Large B-cell Lymphoma – bone health health in patients post R-CHOP and CAR T-cell therapy • Mantle Cell Lymphoma – mankhwala atsopano ophatikizidwa ndi chemotherapy • Kuyezetsa magazi kwa DNA • Katemera wa Lymphoma
Chronic Lymphocytic Leukemia (CLL) & Small Lymphocytic Leukemia (SLL)
Dr Brian Koffman - Zosintha za CLL & kulengeza kwa odwala.
Dr. Koffman, dokotala wodziwika bwino, wophunzitsa ndi pulofesa wa zachipatala adatembenuza wodwala CLL, wadzipereka yekha kuphunzitsa ndi kuthandiza anthu a CLL kuyambira pamene adamupeza mu 2005. Dr. Koffman amakhulupirira kuti udindo wake wapawiri monga dokotala ndi wodwala amapereka wapadera. chidziwitso ndi kumvetsetsa zomwe zimamupangitsa kuti afotokoze momveka bwino za zovuta zovuta komanso kulimbikitsa odwala anzake ndikudziwitsa anzake azachipatala. Izi ndizofunikira makamaka chifukwa cha kusintha kwamphamvu kwachipatala. Dr Koffman ndi woyambitsa mnzake wa CLL Society, USA. Dr Koffman adakambirana zosintha za CLL kuchokera kumsonkhanowu kuphatikiza zosintha za CAR T-cell therapy, ibrutinib, acalabrutinib, kutsatizana kwamankhwala ndi mankhwala ophatikizira osiyanasiyana. Adakambirananso za kayendetsedwe kabwino ka CLL, kuphatikiza kuyezetsa ma genetic musanalandire chithandizo komanso odwala omwe ali ndi matenda osasinthika, 17p del sayenera kukhala ndi chemotherapy, m'malo mwake chithandizo chomwe chimayang'aniridwa.
Prof John Gribben ndi Deborah Sims - Chidule cha chithandizo cha CLL.
Prof Gribben adakambirana za malingaliro ake pazosintha zomwe zachitika pamsonkhanowo pomwe zowonetsera zambiri zidatsimikizira kuti chithandizo chomwe chikugwiritsidwa ntchito ndi chabwino chifukwa chatsatiridwa kwanthawi yayitali. Ndi kutsatira kwautali kumabweranso chidziwitso cha poizoni watsopano yemwe angawonekere. Kenako titha kuphunzitsa odwala bwino ndikukhala ndi malingaliro abwino pazomwe angayembekezere. Adakambirananso zamankhwala am'badwo watsopano omwe adayambitsidwa, osati mu CLL, komanso ma lymphoma ena monga Follicular lymphoma & Mantle cell lymphoma. Palinso mayesero ambiri azachipatala oyambilira omwe ali ndi mankhwala atsopano omwe amalonjeza. Chodetsa nkhawa chotsatira ndichakuti ndi machiritso atsopanowa komanso machiritso ophatikizika, amabweretsa ndalama zochulukirapo zamakachitidwe azaumoyo.
Prof Stephan Stilgenbauer ndi Deborah Sims - Zosintha pa kayendetsedwe ka CLL/SLL.
Prof Stilgenbauer anapereka mwachidule zosintha zachipatala kwa odwala omwe ali ndi CLL/SLL kuchokera ku msonkhano wa ASH. Amakambirana za kugwiritsa ntchito mankhwala atsopano ngati othandizira amodzi komanso ophatikiza omwe ali ndi zotsatira zazikulu kwa odwala, makamaka omwe ali ndi matenda osasinthika motero samayankha kumayendedwe achikhalidwe a chemotherapy. Thandizo lamtsogolo la CLL/SLL litha kukhala kuti chemotherapy ikhoza kukhala yachiwiri kapena yachitatu.
A/Prof Constantine Tam ndi Deborah Sims - CLL & Mantle Cell Lymphoma.
A/Prof Constantine Tam, Peter MacCallum Cancer Center, RMH & St Vincent's Hospital analankhula ndi Deborah Sims, wochokera ku Lymphoma Australia. Dr Tam akupereka zidziwitso zake kuchokera pazabwino kwambiri pamsonkhano wa CLL ndi Mantle cell lymphoma. Adapereka mwachidule maulaliki ake atatu oyamikiridwa kwambiri a Chronic Lymphocytic Leukemia (CLL) & Small Lymphocytic Lymphoma (SLL).
Dr George Amatsatira - Zosintha za CLL.
Dr George Follows wochokera ku UK analankhula ndi Lymphoma Australia pamsonkhano wa American Society of Hematology (ASH) womwe unachitikira posachedwapa ku Orlando, USA. Dr Follows ndi Lymphoma/CLL Clinical Lead ku Cambridge ndipo amakhala ndi maudindo angapo kuphatikiza wapampando wa UK CLL forum. Adakambirana zosintha pa kafukufuku waposachedwa ndi zotsatira za kafukufuku zomwe zidaperekedwa pamsonkhano wa ASH pa CLL.
Dr Nitin Jain ndi Deborah Sims - Ibrutinib & Venetoclax mwa odwala CLL.
Dr Nitan Jain ndi Pulofesa Wothandizira mu Dipatimenti ya Leukemia ku yunivesite ya Texas MD Anderson Cancer Center ku Houston, Texas, USA. Dr Nitan anakambilana zokamba zake za 2 pamsonkhano wa ASH wa maphunziro a 2 omwe adachitika ku MD Anderson Cancer Center pogwiritsa ntchito Ibrutinib ndi venetoclax ndi odwala omwe ali ndi matenda a lymphocytic leukemia (CLL) pa chithandizo choyamba komanso omwe ali ndi matenda obwereranso / otsutsa. Zotsatira zinasonyeza kuti m'magulu onsewa chithandizo chophatikizana chogwiritsira ntchito ibrutinib ndi venetoclax ndi njira yabwino yopangira mankhwala a chemotherapy kwa odwala omwe ali ndi CLL ndipo maphunziro ena adzapitirirabe.
Dr Tanya Siddiqi - CAR T-selo mu CLL yobwereranso / yokana.
Dr Tanya Siddiqi ndi Mtsogoleri, Chronic Lymphocytic Leukemia Program, Toni Stephenson Lymphoma Center ndi A/Prof Department of Hematology & Hematopoietic Transplantation ku City of Hope National Medical Center, Duarte, USA. Dr Siddiqi adakambirana zomwe adafotokoza pamsonkhano wa gawo loyamba lothandizira odwala omwe abwerera m'mbuyo kapena opumira omwe ali ndi CLL. Odwala onse anali atalandirapo kale mankhwala osachepera atatu, kuphatikizapo ibrutinib ndi theka la odwala adalandiranso venetoclax. Kafukufukuyu adathandiza odwala 3 omwe adalandira chithandizo cha CAR T-cell pomwe opitilira 23% adapeza mayankho okhazikika pamiyezi isanu ndi umodzi. Kutsatira kukupitilira.
Prof John Seymour - Chidule cha kafukufuku wa Murano - CLL/SLL.
Prof Seymour adapereka kuwunika kwazaka zinayi kwa kafukufuku wa Murano komwe kumatsimikizira phindu lokhazikika la nthawi yochepa ya Venetoclax & rituximab mu relapsed or refractory chronic lymphocytic leukemia (CLL). Venetoclax (Ven) ndi choletsa chapakamwa chosankha kwambiri cha key apoptosis regulator BCL-2, chomwe chimachulukitsidwa kwambiri mu CLL. MURANO (kafukufuku wa Gawo lachitatu) poyerekeza ndi nthawi yokhazikika ya VenR yokhala ndi bendamustine-rituximab (BR) mu R/R CLL. Kupulumuka kwapamwamba kopanda kupitilira (PFS) kwa VenR motsutsana ndi BR kudakhazikitsidwa pakuwunika koyambirira kokonzekera (Seymour et al. N Engl J Med 2018); kupitirizabe kupindula kwa PFS kunkawoneka ndikutsatira nthawi yayitali komanso odwala onse atamaliza mankhwala.
Pulofesa Peter Hillmen - Zovuta pazachipatala za CLL/SLL.
Prof Hillman akukambirana za zovuta zina zakusintha mwachangu kwamankhwala a CLL/SLL okhala ndi njira zambiri zochiritsira zatsopano pamsika.
Prof Peter Hillmen - CLL zosintha kuchokera ku ASH 2019.
Pulofesa Hillmen anakambilana zina mwa mfundo zofunika kwambiri pa msonkhano wa zoyeserera zachipatala zomwe zinagwiritsidwa ntchito poyambirira zomwe zinasonyeza zotsatira zabwino pogwiritsa ntchito ibrutinib (BTK inhibitor), acalabrutinib (new generation BTK inhibitor), venetoclax (BCL2 inhibitor). ) ndi kugwiritsa ntchito mankhwala osakaniza. Anakambilananso za mayesero azachipatala m'malo obwereranso omwe akuwonetsa zotsatira zabwino zomwe zimaphatikizapo CAR T-cell therapy. Zikomo ku Leukemia Care pogawana zokambirana ndi Lymphoma Australia.
Pulofesa Miles Prince - Kuyesa kwa majini (CLL/SLL) & CAR T-cell therapy.
Prof Prince adakambirana malingaliro ake pamitu yofunika kwambiri ya lymphoma pamsonkhano. Ananenanso kuti njira yabwino yothandizira odwala lymphoma, matenda ake ayenera kumveka bwino komanso kudziwika bwino. Zasonyezedwa kuti odwala omwe ali ndi CLL/SLL amafunika kuyezetsa majini asanalandire chithandizo. Odwala omwe sanasinthe ndi TP53 mutasintha CLL / SLL, chemotherapy yasonyezedwa kuti siili yothandiza kwa gulu la odwala. Ku USA ndi UK (ndi mayiko ena a ku Ulaya) odwala amapatsidwa ndalama zothandizira Ibrutinib kutsogolo, komabe izi sizili choncho ku Australia, kumene odwala amalandira chemo-immunotherapy ndi ibrutinib mu chithandizo chachiwiri.
Kufalitsa Large B-cell Lymphoma (DLBCL)
A/Prof Chan Cheah – Aggressive Lymphoma, Diffus Large B Cell lymphomas.
A/Prof Cheah akuwunikiranso pepala la "Aggressive Lymphoma (Diffuse Large B-cell ndi ma b-cell ena omwe si a Hodgkin lymphomas) - zotsatira za mayesero azachipatala omwe akuyembekezeka: optimizing frontline chemotherapy" gawo lomwe lidachitika Lamlungu 8 Disembala ku ASH 2019.
Dr Jason Westin - Diffuse Large B-cell Lymphoma updates & Smart Start Study.
Dr Westin anakambilana zina mwa mfundo zazikuluzikulu za msonkhano wa DLBCL kuphatikizapo CAR T-cell therapy ndi zosintha kuchokera ku maphunziro omwe amagwiritsa ntchito mankhwala ochepa a chemotherapy motero amawongolera zotsatira za poizoni kwa odwala.
Lymphoma Yotsatira
Dr Loretta Nastoupil - Phunziro la Follicular lymphoma - Gawo 1.
Dr Nastoupil akukambirana za zotsatira za phunziro lake la gawo lachiwiri la Obintuzumab (mtundu wa II anti-CD20 monoclonal antibody) ndi Lenalidamide (immunomodulatory agent) mu FL yomwe inali yosachiritsidwa kale, yolemetsa kwambiri. Kuphatikizika kwa mankhwalawa kumawoneka kuti kumaloledwa bwino komanso kothandiza mu phunziro lapitalo kwa odwala omwe amachiritsidwa mu FL yobwereranso kapena refractory.
Dr Loretta Nastoupil - Phunziro la Follicular lymphoma - Gawo 2.
Dr Nastoupil anakambilana za zotsatira za phunziro lake la gawo lachiwiri la Obintuzumab (mtundu wa II anti-CD20 monoclonal antibody) ndi Lenalidamide (immunomodulatory agent) m'mbuyomu yomwe inali yosachiritsidwa, yolemetsa kwambiri ya FL. Kuphunziranso kogwira mtima, njira yochizira chitetezo cha mthupi mu FL yopanda chithandizo ndiyoyenera. Dr Nastoupil akufotokoza zifukwa zomwe zimapangitsa kuti pakhale njira yothandiza komanso yololera kwa odwala omwe ali ndi Follicular lymphoma.
A/Prof Chan Cheah – Follicular lymphoma clinical trial update update.
Dr Cheah adakambirana zomwe Dr Loretta Nastoupil wochokera ku MD Anderson Cancer Center, Texas pamsonkhano wa ASH 2019. Kafukufuku wa gawo lachiwiri adayang'ana pochiza odwala omwe sanalandire chithandizo cha Follicular lymphoma ndi Obintuzumab (mtundu wa II anti-CD20 monoclonal antibody) ndi Lenalidamide (immunomodulatory agent), omwe ali ndi chotupa chachikulu. Kuphatikizika kwa machiritsowa kunawonedwa kuti ndikololedwa bwino komanso kogwira ntchito mu kafukufuku wam'mbuyomu kwa odwala omwe adalandiranso chithandizo chamankhwala obwereranso kapena osasinthika a FL omwe adachitika ku MD Anderson Cancer Center ndi Prof Nathan Fowler (RELEVANCE study).
Dr Allison Barraclough -Nivolumab + Rituximab mu First Line Follicular Lymphoma.
Dr Barraclough anakambilana za zotsatira za kanthawi kochepa za kafukufuku woyamba wa gawo lachiwiri la dziko lapansi, motsogozedwa ndi Dr Eliza Hawkes, kasamalidwe ka odwala omwe ali ndi gawo 1-3A follicular lymphoma. Phunziroli limagwiritsa ntchito njira yophatikizira chitetezo cha mthupi, yomwe idayesedwa kale m'malo obwereranso. Odwala amalandira nivolumab kwa masabata oyambirira a 8 ndipo ngati akwaniritsa yankho lathunthu, adzapitiriza ndi wothandizira mmodzi nivolumab. Kwa iwo omwe adangopindula pang'ono atha kukhala ndi kuphatikiza kwa nivolumab ndi rituximab. Zotsatira zinali zabwino ndi kuchuluka kwa mayankho (ORR) a 80% ndipo opitilira theka la odwalawa adapeza yankho lathunthu (CR). Panali mawonekedwe otsika kawopsedwe, pomwe odwala ambiri adathabe kugwira ntchito ndikupitiliza ntchito zanthawi zonse
Mantle Cell Lymphoma
Dr Sasanka Handunetti – Mantle Cell Lymphoma (Kusinthidwa kwa kafukufuku wa AIM).
Dr Handunetti adakambirana za ulaliki wake wokhudza kusinthika kwazaka zitatu kwa gawo lachiwiri la kafukufuku wa AIM (TAM, et al, NEJM 2018) wochitidwa ku Peter MacCallum Cancer Center ku Melbourne, pogwiritsa ntchito kuphatikiza BTK inhibitor ibrutinib ndi BCL-2 inhibitor venetoclax therapy kwa odwala omwe ali Kusauka kwa mantle cell lymphoma (MCL). Zotsatira zikuwonetsa kupulumuka kwapakatikati kwa miyezi 29. Zinabweretsa funso loti pali kuthekera kwa chithandizo chanthawi yayitali chokhazikika pakuwongolera MCL yobwereranso kapena kukana.
Prof Steven Le Gouill - kafukufuku wa Mantle Cell Lymphoma.
Pulofesa Le Gouill adakambirana za gawo lake loyamba la maphunziro a MCL omwe angopezeka kumene pogwiritsa ntchito Ibrutinib, Venetoclax ndi Obintuzumab omwe adawonetsedwa kale kuti ali ndi mphamvu pakubwezeretsanso / kukana ngati othandizira amodzi komanso kuphatikiza mu MCL yobwereranso / kukana (R/R) . Anaperekanso ndondomeko ya chisamaliro cha odwala omwe ali ndi MCL kwa wodwala wamng'ono komanso wodwala wamkulu kutsogolo ndi R / R kasamalidwe.
Prof Simon Rule - Mantle Cell Lymphoma Update.
Pulofesa Simon Rule adakambirana za chithunzi chake pamsonkhanowo akuyang'ana kutsata kwa zaka 7.5 kwa odwala omwe ali ndi matenda a MCL omwe adabwereranso kapena omwe ali ndi odwala pa ibrutinib (BTK inhibitor) omwe amasonyeza odwala ambiri omwe adakali ndi chikhululukiro choposa zaka 5. Zinawonetsanso kuti odwala omwe adalandira Ibrutinib m'mizere yoyambirira yamankhwala anali ndi yankho lokhalitsa, kuposa omwe adalandira lateistique.
KTE-X19: Njira ya CAR T-Cell ya Mantle Cell Lymphoma?
Odwala makumi asanu ndi anayi mphambu atatu pa 19 aliwonse omwe ali ndi vuto lobwereranso / refractory mantle cell lymphoma (MCL) adalandira chithandizo ndi KTE-X19, autologous anti-CD2 chimeric antigen receptor (CAR) T-cell therapy, malinga ndi zotsatira za mayesero a ZUMA-2019 omwe adaperekedwa. pa Msonkhano Wapachaka wa XNUMX ASH.
Hodgkin Lymphoma
Dr Jessica Hochberg - Chemotherapy, Achinyamata Achikulire & Hodgkin Lymphoma.
Machiritso a Hodgkin Lymphoma omwe angopezeka kumene ndi okwera kwambiri akamagwiritsidwa ntchito limodzi ndi chemoradiotherapy. Komabe, izi nthawi zambiri zimabweretsa zovuta zakuthupi komanso zamaganizidwe zomwe zimatha kusokoneza kwambiri moyo wa opulumuka. Kuphatikizidwa kwa Brentuximab vedotin ndi Rituximab kuphatikizira kuphatikizika kwa chemotherapy (popanda cyclophosphamide, etoposide kapena bleomycin) kwa Hodgkin Lymphoma yomwe yangopezeka kumene ikuwoneka kuti ndi yotetezeka kwa ana, achinyamata ndi achinyamata. Zotsatira zathu zikuwonetsa lonjezano lofunika kwambiri ndi CR mlingo wa 100%, 58% mofulumira kuyankha koyambirira komanso kuchepetsa kwakukulu kwa kugwiritsa ntchito mankhwala oopsa a chemotherapy ndi ma radiation. EFS/OS mpaka pano ndi 100% yokhala ndi nthawi yotsatiridwa yapakatikati yazaka zopitilira 3.5.
Prof Andrew Evens - HoLISTIC Hodgkin Lymphoma International Study.
Prof Evens ndi membala wokangalika wa HoLISTIC (Hodgkin Lymphoma International Study for Individual Care) - bungwe lapadziko lonse lapansi lomwe limagwirizanitsa gulu la akatswiri osiyanasiyana padziko lonse lapansi kuti aphunzire mbali zazikulu za matenda a Hodgkin lymphoma, miliri, chithandizo, kupulumuka ndi zotsatira za thanzi. m'magulu onse azaka. Iwo akugwirizanitsa deta ya wodwala aliyense kuchokera ku mayesero achipatala amakono oposa 20 ochokera ku North America ndi Europe azaka zonse komanso 6 mabungwe ndi zigawo za Hodgkin lymphoma registries, ndi machitidwe akuluakulu a oncology. Cholinga chawo ndi kupititsa patsogolo zisankho za ana ndi akuluakulu a Hodgkin lymphoma odwala ndi opereka chithandizo, kupatsidwa njira zowonjezera zothandizira komanso popanda chidziwitso chokwanira komanso chokhalitsa.
Dr Stephen Ansell ndi Deborah Sims - Hodgkin Lymphoma.
Dr Ansell ndi katswiri wotsogola wa non-Hodgkin lymphoma ndi Hodgkin lymphoma ku Mayo Clinic, USA. Dr Ansell analankhula za Hodgkin lymphoma – front line therapy session ku ASH komwe anali atangopitako kumene. Gawoli lidawunikira mayeso azachipatala omwe adagwiritsidwanso ntchito m'machiritso atsopano pamzere wakutsogolo, pomwe kuwonjezera Brentuximab Vedotin & PD-1 inhibitor ndikuchepetsa ena mwamankhwala odziwika bwino omwe anali bleomycin, adawonetsa zotsatira zabwino kwambiri. Zotsatirazo zinachepetsanso poizoni kwa odwala omwe amalandira chithandizochi poyerekeza ndi mankhwala ochiritsira. Thandizo lokhazikika mu Hodgkin lymphoma lili ndi kuchuluka kwa mayankho onse pomwe pafupifupi 90% odwala amafika kuyankha kwathunthu kwa metabolic. Mayesero ambiri a Hodgkin lymphoma pakadali pano akufuna kuchepetsa mbiri ya kawopsedwe ndi zotsatira zochedwa kwa odwalawa.
Mphepo yam'mphepete mwa Lymphoma
Dr Sasanka Handunetti - Gawo II Phunziro mu Relapsed kapena Refractory Marginal Zone Lymphoma.
Dr Handunetti anakambilana za chikwangwani chochokera ku gulu la Peter MacCallum Cancer Center pamsonkhano wa ntchito ya ibrutinib pamodzi ndi venetoclax kwa odwala omwe abwereranso kapena kukana Marginal Zone Lymphoma (MZL). MZL ndi matenda osachiritsika omwe palibe muyezo wa chithandizo chamankhwala pakubwereranso kapena kukana. Mankhwala onsewa ankawoneka kuti ali ndi umboni wa ntchito ndi kulekerera monga monotherapies (othandizira amodzi) ndipo phunziroli likufuna kuyesa yankho ngati mankhwala osakaniza.
Central Nervous System Lymphoma
Dr Katherine Lewis - Primary Central Nervous System Lymphoma (PCNSL).
Dr Lewis adakambilana za chikwangwani cha ASH 2019 chomwe chidawona zotsatira za odwala omwe ali ndi ma lymphoma apakati kapena apakati (ubongo ndi msana) omwe amathandizidwa ndi Ibrutinib (BTK inhibitor). Iyi ndi lymphoma yosowa komanso yaukali pomwe gulu la odwalawa silinadziwike bwino ndipo nthawi zambiri limathandizidwa ndi mankhwala ophatikizika kwambiri a chemotherapy. Uwu unali kafukufuku wobwereza womwe udasonkhanitsa zambiri kuchokera ku Australia ndi New Zealand mwa odwala 16 omwe adathandizidwa ndi monotherapy Ibrutinib mumayendedwe obwereranso / okana. Ngakhale odwala ochepa, zotsatira zake zinali zodalirika, ndi mayankho ofika ku 81%.
Macroglobulinemia wa Waldenstrom
Prof Mathias Rummel – Macroglobulinemia ya Waldenstrom & the StiL trial.
Imaphimba zotsatira zazaka za 2 pambuyo pa kafukufuku wa StiL kuyang'ana pakukonza Rituximab vs observation post bendamustine-rituximab. Zotsatira zikuwonetsa kuti kukonza rituximab sikuthandiza kuti moyo ukhale wabwino. Prof Rummel amaperekanso chidule cha kasamalidwe ka WM.
T-cell Lymphoma
Peripheral T-cell Lymphoma
Dr Jasmine Zain, MD - akukambirana za maphunziro ochititsa chidwi kwambiri mu PTCL operekedwa ku ASH 2019.
(Zikomo ku OBRoncology).
Dr. Zain, Mtsogoleri wa T-cell Lymphoma Program, Dipatimenti ya Hematology ndi Hematopoietic Cell Transplantation, Toni Stephenson Lymphoma Center, City of Hope, akukambirana maphunziro ochititsa chidwi kwambiri pochiza zotumphukira T-cell lymphoma (PTCL) zoperekedwa ku ASH. 2019.
Dr Jasmine Zain - Momwe chithandizo cha zotumphukira za T-cell lymphoma zasinthira.
(Zikomo ku OBRoncology).
Dr. Zain, Mtsogoleri wa T-cell Lymphoma Program, Dipatimenti ya Hematology ndi Hematopoietic Cell Transplantation, Toni Stephenson Lymphoma Center, City of Hope, akuwona momwe peripheral T-cell lymphoma (PCL) therapy yasinthira zaka zaposachedwapa.
Dr Jasmine Zain - Njira Zatsopano zochizira PTCL kuphatikiza CAR T-cell therapy.
(Zikomo ku OBRoncology).
Dr. Zain, Mtsogoleri wa T-cell Lymphoma Program, Dipatimenti ya Hematology ndi Hematopoietic Cell Transplantation, Toni Stephenson Lymphoma Center, City of Hope, amatiuza za njira zina zamakono zomwe zimapangidwira pochiza matenda a T-cell lymphoma ( PTCL).
Dr Timothy Illidge, akufotokoza cholinga cholunjika ku PTCL.
(Zikomo ku OBRoncology).
Dr. Illidge, Pulofesa wa Targeted Therapy and Oncology, Division of Cancer Sciences, Chipatala cha Christie, University of Manchester, akufotokoza cholinga cholunjika pa peripheral t-cell lymphoma (PTCL).
