Australian lymphoma patients will now have access to a new frontline therapy for CLL*

New treatments available

The combination of VENCLEXTA plus obinutuzumab will be available as a fixed duration therapy for previously untreated patients with CLL who are unfit for chemotherapy.

Lymphoma Australia welcomes the announcement by The Federal Minister for Health, The Hon. Greg Hunt MP, that Venclexta® (venetoclax) in combination with obinutuzumab will be available to eligible Australians with Chronic Lymphocytic Leukaemia (CLL) as a first line therapy via the Pharmaceutical Benefits Scheme (PBS) from the 1st December 2020.

This PBS listing will allow CLL patients who cannot be treated with standard chemotherapy-based treatments to have affordable access to this first line combination treatment. This targeted therapy will be especially beneficial for patients that are unfit or cannot tolerate chemotherapy due to side effects and other comorbidities.

Clinicians and patients now have options to best suit the needs of patients and this can mean a huge difference in outcomes for these patients, said Sharon Winton CEO Lymphoma Australia.

Venclexta was developed as part of a research collaboration between AbbVie, Genentech, a member of the Roche Group of Companies, and the Walter and Eliza Hall Institute in Melbourne, Australia.3

Professor John Seymour, MBBS, Director of Clinical Haematology at the Peter MacCallum Cancer Centre and Royal Melbourne Hospital, says the new listing for the locally discovered treatment is a positive development for cancer patients.

“This reimbursement represents another important milestone for Australia. Venclexta is the result of 30 years of research and collaboration. It is positive to see that this home-grown discovery has now evolved into a medicine that more Australians can have funded access to,” said Professor Seymour.

*Chronic lymphocytic leukaemia (CLL) is a lymphoproliferative disorder hence it is classified as a lymphoma. It is an incurable lymphoma found in the lymphocytes, a type of white blood cell involved in the body’s immune system. CLL is classified by the accumulation and rapid reproduction of clonal B cells in the blood, marrow and lymph nodes. The progression of CLL is extremely variable ranging from indolent (slow growing) disease not requiring treatment to one that progresses rapidly and is resistant to treatment.

Lymphoma Coalition – Global Subtype Report CLL Report – Lymphoma Coalition

AbbVie media release: https://www.abbvie.com.au/media/venclexta-cll-therapy.html 

For media comment, contact Sharon Winton, CEO on 0431 483 204

For more info see
To learn more about CLL/SLL please click here
Media coverage: 
Hon Greg Hunt has announced another new PBS listing for CLL patients.
From Dec 1, breakthrough medicine Venclexta® will be expanded on the PBS for patients living with chronic lymphocytic leukaemia Without subsidy, 500 patients each year would pay more than $69,000 per course of treatment. They will now pay $41 or $6.60 with a concession card.
 
Great interview featuring patient advocate Deborah Sims and her son Cameron on Ten News First; 29 November 2020.
 
Greg Hunt on Twitter
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Please note: Lymphoma Australia staff are only able to reply to emails sent in English language.

For people living in Australia, we can offer a phone translation service. Have your nurse or English speaking relative call us to arrange this.

Useful Definitions

  • Refractory: This means the lymphoma does not get better with treatment. The treatment didn’t work as hoped.
  • Relapsed: This means the lymphoma came back after being gone for a while after treatment.
  • 2nd line treatment: This is the second treatment you get if the first one didn’t work (refractory) or if the lymphoma comes back (relapse).
  • 3rd line treatment: This is the third treatment you get if the second one didn’t work or the lymphoma comes back again.
  • Approved: Available in Australia and listed by the Therapeutics Goods Administration (TGA).
  • Funded: Costs are covered for Australian citizens. This means if you have a Medicare card, you shouldn’t have to pay for the treatment.[WO7]

You need healthy T-cells to make CAR T-cells. For this reason, CAR T-cell therapy cannot be used if you have a T-cell lymphoma – yet.

For more information on CAR T-cells and T-cell lymphoma click here. 

Special Note: Although your T-cells are removed from your blood for CAR T-cell therapy, most of our T-cells live outside of our blood – in our lymph nodes, thymus, spleen and other organs.