Radford Discusses Future of Novel Therapies in Non-Hodgkin Lymphoma

Several novel agents, including idelalisib (Zydelig), belinostat (Beleodaq), and ibrutinib (Imbruvica), have shown promise across multiple types of non-Hodgkin lymphoma (NHL). These new therapies, among others, have changed the treatment paradigm for NHL, significantly improving outcomes for patients.

John Radford, MD, Teenage Cancer Trust Professor of Teenage and Young Adult Cancer at the University of Manchester and Director of Research at the Christie NHS Foundation Trust, has focused his research on new treatments of lymphoma and monitoring their efficacy using novel biomarkers and the late effects of both standard and novel treatments in NHL.

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Useful Definitions

  • Refractory: This means the lymphoma does not get better with treatment. The treatment didn’t work as hoped.
  • Relapsed: This means the lymphoma came back after being gone for a while after treatment.
  • 2nd line treatment: This is the second treatment you get if the first one didn’t work (refractory) or if the lymphoma comes back (relapse).
  • 3rd line treatment: This is the third treatment you get if the second one didn’t work or the lymphoma comes back again.
  • Approved: Available in Australia and listed by the Therapeutics Goods Administration (TGA).
  • Funded: Costs are covered for Australian citizens. This means if you have a Medicare card, you shouldn’t have to pay for the treatment.[WO7]

You need healthy T-cells to make CAR T-cells. For this reason, CAR T-cell therapy cannot be used if you have a T-cell lymphoma – yet.

For more information on CAR T-cells and T-cell lymphoma click here. 

Special Note: Although your T-cells are removed from your blood for CAR T-cell therapy, most of our T-cells live outside of our blood – in our lymph nodes, thymus, spleen and other organs.