New drug a blood cancer game changer

A breakthrough drug with its origins in Melbourne is driving a major shift in the treatment of blood cancers. Venetoclax was developed from scientific discoveries made at the Walter and Eliza Hall Institute of Medical Research, and Melbourne scientists continue to lead its clinical trials which are showing dramatic results in hard-to-treat patients with Chronic Lymphocytic Leukaemia (CLL) and Mantle-Cell Lymphoma (MCL). 

“The development of venetoclax – from basic science through to international clinical trials with practice-changing results – provides a strong example of how Australian cancer researchers and clinicians can lead the world,” says Professor Andrew Roberts, a clinical haematologist at RMH and Peter Mac, researcher at the Walter and Eliza Hall Institute and University of Melbourne, and co-designer of the AIM study.

“Venetoclax selectively targets BCL-2, essentially causing cancerous cells to simply melt away, in many instances.”

Read more about the latest Peter Mac and Royal Melbourne Hospital trial results here: https://www.petermac.org/news/melbourne-drug-blood-cancer-game-changer

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Useful Definitions

  • Refractory: This means the lymphoma does not get better with treatment. The treatment didn’t work as hoped.
  • Relapsed: This means the lymphoma came back after being gone for a while after treatment.
  • 2nd line treatment: This is the second treatment you get if the first one didn’t work (refractory) or if the lymphoma comes back (relapse).
  • 3rd line treatment: This is the third treatment you get if the second one didn’t work or the lymphoma comes back again.
  • Approved: Available in Australia and listed by the Therapeutics Goods Administration (TGA).
  • Funded: Costs are covered for Australian citizens. This means if you have a Medicare card, you shouldn’t have to pay for the treatment.[WO7]

You need healthy T-cells to make CAR T-cells. For this reason, CAR T-cell therapy cannot be used if you have a T-cell lymphoma – yet.

For more information on CAR T-cells and T-cell lymphoma click here. 

Special Note: Although your T-cells are removed from your blood for CAR T-cell therapy, most of our T-cells live outside of our blood – in our lymph nodes, thymus, spleen and other organs.