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This page explains what clinical trials are, how they work, how you can join one, and what types of trials are happening now for people with lymphoma.
A clinical trial is a type of research that tests a new treatment or a new way to use an existing treatment. Trials are done in stages (called phases) to make sure the treatment is safe and works well.
Every trial has rules about who can take part. These are called eligibility criteria. Before joining a clinical trial, you will be screened (tested) to see if the trial is a good match for you.
Ask your doctor if there are any clinical trials you could be screened for. Trials are not right for everyone, but they may be a good option for some people – especially if standard treatments haven’t worked.
If you qualify, your doctor will explain the risks and benefits before you decide to join the trial or not.
Yes, some clinical trials do allow children to join. Ask your child’s oncologist or haematologist if there are any clinical trials your child can be screened for.
Australia has several clinical trials for CAR T-cell therapy. These trials are looking at:
Ask your doctor or care team if there is a trial that matches your lymphoma type and treatment history.
Yes. Many CAR T-cell trials are happening in the United States, Europe, and Asia. If you are not eligible for a clinical trial in Australia, you may be able participate in one overseas. However, in many cases you may need to pay for your own travel and accommodation where the trial is being held.
Let your doctor know if you are willing to travel overseas for a clinical trial.
Clinical trials may help improve lymphoma treatment. CAR T-cell trials are testing new targets, new timing, and new lymphoma types. If you’re interested in joining a trial:
Research is moving fast. Today’s trials could be tomorrow’s treatments.
If you need help finding a trial, talk to your healthcare team. You can also check the Australian New Zealand Clinical Trials Registry (ANZCTR) or contact Lymphoma Australia on 1800 953 081 or email nurse@lymphoma.org.au for more information.
Speak to your haematologist about whether you are eligible or appropriate to have CAR T-cell therapy. If so, your haematologist can arrange a referral.
For any queries related to patient eligibility for CAR T-cell therapy or how patients can access this treatment, please email:
CAR-T.enquiry@petermac.org
You can contact the Lymphoma Nurse Support Line: T 1800 953 081 or email: nurse@lymphoma.org.au for further information or advice.
To diagnose lymphoma you will need a biopsy. A biopsy is a procedure to remove part, or all of an affected lymph node and/ or a bone marrow sample. The biopsy is then checked by scientists in a laboratory to see if there are changes that help the doctor diagnose lymphoma.
When you have a biopsy, you may have a local or general anaesthetic. This will depend on the type of biopsy and what part of your body it is taken from. There are different types of biopsies and you may need more than one to get the best sample.
Core or fine needle biopsies are taken to remove a sample of swollen lymph node or tumour to check for signs of lymphoma.
Your doctor will usually use a local anaesthetic to numb the area so you don’t feel any pain during the procedure, but you will be awake during this biopsy. They will then put a needle into the swollen lymph node or lump and remove a sample of tissue.
If your swollen lymph node or lump is deep inside your body the biopsy may be done with the help of ultrasound or specialised x-ray (imaging) guidance.
You might have a general anaesthetic for this (which puts you to sleep for a little while). You may also have a few stitches afterwards.
Core needle biopsies take a bigger sample than a fine needle biopsy.
During this procedure, a surgeon will remove the whole lymph node or lump and send it to pathology for testing. You may have a general anaesthetic which will put you to sleep for a little while, so you stay still and feel no pain.
You will have a small wound with a few stitches, and a dressing over the top.
Stitches usually stay in for 7-10 days, but your doctor or nurse will give you instruction on how to care for the dressing, and when to return to have the stitches out.
Excisional node biopsies are more reliable than fine needle or core needle biopsies for diagnosing lymphoma.
Blood tests are taken when trying to diagnose your lymphoma, but also throughout your treatment to make sure your organs are working properly and can cope with our treatment.
Once your doctor gets the results from you blood tests and biopsies they will be able to tell you if you have lymphoma and may also be able to tell you what subtype of lymphoma you have. They will then want to do more tests to stage and grade your lymphoma.
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To understand lymphoma, you need to know a bit about your B-Cell lymphocytes.
B-Cell lymphocytes:
Lymphoma develops when some of your B-cell lymphocytes (B-cells) become cancerous. They grow uncontrollably, are abnormal, and do not die when they should.
When you have lymphoma your cancerous B-cells:
Some lymphomas grow very quickly, which means the cancerous B-cells are multiplying (making new copies of themselves). Other cancerous B-cells may live longer than they should.. B-cells (and many other cells) are designed to live for a purpose. Once they have achieved that purpose, they naturally die to make room for new stronger healthy B-cells.
In some cases, lymphoma develops when the cancerous B-cells just keep living even when they have no purpose. They then take up too much room which can stop your body making new healthy cells.
Please note:
Lymphoma Australia staff are only able to reply to emails sent in English language.
You need healthy T-cells to make CAR T-cells. For this reason, CAR T-cell therapy cannot be used if you have a T-cell lymphoma – yet.
For more information on CAR T-cells and T-cell lymphoma click here.
Special Note: Although your T-cells are removed from your blood for CAR T-cell therapy, most of our T-cells live outside of our blood – in our lymph nodes, thymus, spleen and other organs.