New CAR T Cell Therapy option now available in Australia for some patients with Lymphoma

Eligible patients can now access Yescarta through Royal Brisbane and Women’s Hospital, Brisbane and the Peter MacCallum Cancer Centre, Melbourne with Sydney sites to follow.

Kite, a Gilead company, today announced that its Chimeric Antigen Receptor (CAR) T cell therapy, Yescarta® (axicabtagene ciloleucel), is now publicly funded and available to patients in Australia. Yescarta is now funded for the treatment of adult patients with relapsed or refractory CD-19 positive; diffuse large B-cell lymphoma (DLBCL), primary mediastinal large B-cell lymphoma (PMBCL), transformed follicular lymphoma (TFL) and high-grade B-cell lymphoma (HGBCL) who meet the eligibility criteria.

Haematologist and Lead of the Aggressive Lymphoma disease group at the Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Associate Professor Michael Dickinson, said: “Many people living with these four forms of non-Hodgkin lymphoma, who have either not responded to treatment or where their cancer has returned, have an urgent need for new therapy options to treat this aggressive blood cancer.”

Patients should speak to their clinician about the appropriate treatment option for them.

Sharon Winton, CEO, Lymphoma Australia, commented, “Until recently Australian patients with the approved four aggressive lymphoma subtypes had a very poor prognosis. To have access to another CAR T cell therapy option in Australia is very welcome news for these patients and their families.”

For more information please call our Nurse Support Line on 1800 953 081.

Minister Hunt’s media release: https://www.health.gov.au/ministers/the-hon-greg-hunt-mp/media/lymphoma-patients-to-benefit-from-new-cancer-therapy

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Please note: Lymphoma Australia staff are only able to reply to emails sent in English language.

For people living in Australia, we can offer a phone translation service. Have your nurse or English speaking relative call us to arrange this.

Useful Definitions

  • Refractory: This means the lymphoma does not get better with treatment. The treatment didn’t work as hoped.
  • Relapsed: This means the lymphoma came back after being gone for a while after treatment.
  • 2nd line treatment: This is the second treatment you get if the first one didn’t work (refractory) or if the lymphoma comes back (relapse).
  • 3rd line treatment: This is the third treatment you get if the second one didn’t work or the lymphoma comes back again.
  • Approved: Available in Australia and listed by the Therapeutics Goods Administration (TGA).
  • Funded: Costs are covered for Australian citizens. This means if you have a Medicare card, you shouldn’t have to pay for the treatment.[WO7]

You need healthy T-cells to make CAR T-cells. For this reason, CAR T-cell therapy cannot be used if you have a T-cell lymphoma – yet.

For more information on CAR T-cells and T-cell lymphoma click here. 

Special Note: Although your T-cells are removed from your blood for CAR T-cell therapy, most of our T-cells live outside of our blood – in our lymph nodes, thymus, spleen and other organs.