Other targeted therapies

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Bortezomib (VELCADE®)

Bortezomib is a type of cancer treatment drug called a proteasome inhibitor.

Proteasomes break down proteins in cells and this keeps a balance of proteins in the cell. This is a normal process but also occurs in abnormal cells to keep them alive, for example lymphoma cells. Proteasome inhibitors block the work of proteasomes. This seems to be particularly harmful to certain types of lymphoma cells, which are then no longer able to work properly and die.

Indications

VELCADE in combination with rituximab, cyclophosphamide, doxorubicin, and prednisone is indicated for the treatment of adult patients with previously untreated mantle cell lymphoma.

Administration

You have bortezomib either as an injection under the skin (subcutaneously) into the leg or abdomen. It can also be given as an injection into the bloodstream (intravenously).

It is usually given twice a week for 2 weeks followed by a 10-day rest period in each 3-week cycle. A total of 6 to 8 cycles are usually given for patients with mantle cell lymphoma that has not been treated previously.

Into the bloodstream

The treatment is given through a drip into the arm.

Some patients may need a central line and this is a long plastic tube that gives the drugs into a large vein, either into the chest or through a vein in the arm. A central line stays in for the duration of the treatment and this may be for a few months.

As an injection under the skin

Subcutaneous injections can be given into the stomach, thigh or top of the arm. This may cause a stinging or a dull ache for a short time after this type of injection and the skin in the area may go red and itchy.

Common side effects

  • Numbness or tingling in fingers or toes
  • Pain in muscles or joints
  • High temperature (fever)
  • Constipation
  • Diarrhoea
  • Lowered appetite
  • Nausea and vomiting
  • Tiredness and weakness (fatigue)
  • Anaemia (decreased red blood cells)
  • Thrombocytopenia (decreased platelets)
  • Increased risk of getting an infection
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Please note: Lymphoma Australia staff are only able to reply to emails sent in English language.

For people living in Australia, we can offer a phone translation service. Have your nurse or English speaking relative call us to arrange this.

Useful Definitions

  • Refractory: This means the lymphoma does not get better with treatment. The treatment didn’t work as hoped.
  • Relapsed: This means the lymphoma came back after being gone for a while after treatment.
  • 2nd line treatment: This is the second treatment you get if the first one didn’t work (refractory) or if the lymphoma comes back (relapse).
  • 3rd line treatment: This is the third treatment you get if the second one didn’t work or the lymphoma comes back again.
  • Approved: Available in Australia and listed by the Therapeutics Goods Administration (TGA).
  • Funded: Costs are covered for Australian citizens. This means if you have a Medicare card, you shouldn’t have to pay for the treatment.[WO7]

You need healthy T-cells to make CAR T-cells. For this reason, CAR T-cell therapy cannot be used if you have a T-cell lymphoma – yet.

For more information on CAR T-cells and T-cell lymphoma click here. 

Special Note: Although your T-cells are removed from your blood for CAR T-cell therapy, most of our T-cells live outside of our blood – in our lymph nodes, thymus, spleen and other organs.