Vinorelbine is a type of drug called a vinca alkaloid. Vinca alkaloids are made from the periwinkle plant. Vinorelbine inhibits (obstructs) the microtubule structures within the cell. Microtubules are part of the cell’s framework for dividing and replicating itself. Inhibition of these structures results in cell death.
Indications
- Relapsed/refractory non-Hodgkin lymphoma (NHL)
- Relapsed/refractory Hodgkin lymphoma (HL)
Administration
The doctor will determine the dose and schedule.
The amount of vinorelbine given depends on many factors including:
- Height and weight
- General health or other health problems
- Type of lymphoma being treated
Vinorelbine is given through a vein by intravenous infusion (IV) given via gravity rather than pushed through the IV pump.
Vinorelbine is a vesicant. A vesicant is a chemical that causes extensive tissue damage and blistering if it escapes from the vein. If there is pain, redness or swelling at the IV site whilst receiving vinorelbine, the health care team should be alerted immediately. A nurse will be next to the patient during the infusion to stop the infusion immediately if there are any issues.
Possible side-effects
- Low white blood cells. This can put you at increased risk of infection
- Anaemia (low red blood cells)
- Thrombocytopenia (low platelets). This can put you at increased risk for bleeding.
- Nausea or vomiting
- Loss of appetite
- Fatigue
- Muscle weakness
- Diarrhoea or constipation
- Pain along the site where the medication was given
- Peripheral neuropathy (numbness in your fingers and toes) may occur with repeated doses. This should be reported to your
- Healthcare provider.
- Hair loss
- Sore mouth and throat
- High temperature (fever)
