Maintenance therapy inowanzoshandiswa neanoverengeka lymphoma subtypes nechinangwa chekuchengetedza lymphoma mukuregererwa kwenguva refu.
Chii chinonzi kuchengetedza kurapwa?
Maintenance therapy inoreva kurapwa kunoenderera mberi mushure mekunge kurapwa kwekutanga kwaisa lymphoma mukuregererwa (iyo lymphoma yakaderera kana kuti yapindura kurapwa). Chinangwa ndechekuita kuti kuregererwa kugare kwenguva yakareba sezvinobvira. Rudzi rwerapirwo runonyanya kushandiswa mukugadzirisa ndeye antibody (seRituximab kana Obinutuzumab).
Chemotherapy dzimwe nguva inoshandiswa senzira yekuchengetedza vana uye vechidiki vane lymphoblastic lymphoma. Vanowanzotangwa mukati memwedzi mitanhatu yekutanga mushure mekutanga kurapwa kuchengetedza lymphoma kubva kufambira mberi kana kudzokorora.
Kurapa kwekuchengetedza kunotora nguva yakareba sei?
Zvichienderana nerudzi rwe lymphoma uye mishonga inoshandiswa, kurapwa kwekugadzirisa kunogona kugara kwemavhiki, mwedzi, kana makore. Havasi vese varwere vanokurudzirwa kuve nekuchengetedza kurapa kana lymphoma yavo iri pasi pekutonga mushure mekurapa induction. Yakawanikwa iine zvikomborero mune mamwe ma subtypes e lymphoma.
Rituximab inonzi monoclonal antibody iyo inowanzokurudzirwa sekurapa kwekuchengetedza kune varwere vane marudzi akawanda akasiyana e-non-Hodgkin lymphoma (NHL). Varwere ava vanowanzogamuchira rituximab sechikamu chekurapa kwavo induction, kazhinji musanganiswa nechemotherapy (inonzi chemoimmunotherapy).
Kana lymphoma ikapindura kurapwa kwekutanga, rituximab inogona kukurudzirwa kuti ienderere mberi se'maintenance therapy'. Iyo rituximab muchikamu chekugadzirisa inopihwa kamwe chete pamwedzi 2-3. Rituximab parizvino yakapihwa kwenguva yakareba yemakore maviri, kunyangwe miedzo yekiriniki iri kuyedza kana paine bhenefiti mukurapwa kwekuchengetedza kuenderera kwenguva refu. Pakurapa kwekuchengetedza, rituximab inogona kupihwa intravenously (nejekiseni mutsinga) kana pasi pecutaneously (nejekiseni pasi peganda).
Neimwe nzira, Obinutuzumab (Gazyva) imwe monoclonal antibody inoshandiswawo kuchengetedza varwere vane follicular lymphoma post chemotherapy. Iyo Obinutuzumab inotungamirwa mwedzi miviri yega yega kwemakore maviri.
Ndiani anogamuchira kurapwa kwekuchengetedza?
Maintenance rituximab yakanyanya kushandiswa mune indolent NHL subtypes senge follicular lymphoma. Maintenance therapy parizvino iri kutariswa mune mamwe ma subtypes e lymphomas. Vana uye vechidiki vane lymphoblastic lymphoma vanogona kupiwa kurapwa kwekuchengetedza ne chemotherapy kudzivirira lymphoma yavo kudzoka zvakare. Iyi inzira shoma yechemotherapy.
Ndezvipi zvinobatsira zvekugadzirisa kurapa?
Kuve nekugadzirisa kurapwa ne rituximab kana Obinutuzumab kunogona kuwedzera kureba kwekuregererwa kune varwere vane follicular kana mantle cell lymphoma. Tsvagiridzo yakaratidza kuti kudzoka zvakare kunogona kunonoka kana kudzivirirwa, nekuenderera mberi kana 'kuchengetedza' kurapwa ne rituximab apo varwere vari mukuregererwa. Chinangwa ndechekudzivirira varwere vakapindura kurapwa kwekutanga kubva pakudzoka zvakare asi pakupedzisira vachivandudza kupona kwese. MuAustralia, izvi zvinongopihwa mari pachena (PBS) ye rituximab mu follicular lymphoma.
Ngozi dzekuchengetedza kurapwa
Kunyange zvazvo mishonga inoshandiswa pakugadzirisa marapirwo inowanzova nemigumisiro shoma pane yakasanganiswa chemotherapy, varwere vanogona kuramba vachisangana nezviitiko zvakashata kubva mukurapwa uku. Chiremba achafunga nezvese mamiriro ekiriniki asati aona kurapwa kwekutanga uye kuti murwere angabatsirwa here nekurapa kwekuchengetedza maringe nekumwe kurapwa kana 'tarisa uye kumirira'.
Varwere vazhinji havana matambudziko mazhinji anonetsa panguva yerituximab. Zvisinei, haisi nguva dzose yakakodzera kuti munhu wose agamuchire kurapwa kwekugadzirisa. Mamwe emhedzisiro inogoneka yekugadziriswa Rituximab ndeiyi:
- Allergic reaction
- Kuderedza migumisiro pamasero eropa
- Musoro kana furu sezviratidzo
- Kuneta kana kuneta
- Kuchinja kweganda semapundu
Mishonga iri kuferefetwa semushonga wekuchengetedza
Mazhinji matsva emunhu uye akasanganiswa marapirwo ari kuyedzwa pasi rese kuti ashandise mukuchengetedza kurapa lymphoma. Mimwe yemishonga iyi inosanganisira:
- Bortezomib (Velcade)
- Brentuximab vedotin (Adcetris)
- Lenalidomide (Revlimid)
- Vorinostat (Zolinza)
Tsvagiridzo yesainzi iri kuramba ichishanduka. Nzira dzekurapa dzinogona kushanduka sezvo kurapwa kutsva kunowanikwa uye nzira dzekurapa dzinovandudzwa.
Zvimwe Zvinyorwa
Iwe unogona kuwana rumwe ruzivo nezve kurapwa kwauri kugamuchira nekutevera zvinongedzo pazasi:
