Cell Acute Lymphoblastic Leukaemia/Lymphoma (B-ALL)
What is it?
B-cell Acute Lymphoblastic
Leukaemia/Lymphoma (B-ALL) is a type of aggressive lymphoma that occurs mainly
in children and adolescents, with two-thirds being male. A second peak of occurrence
happens later in life in people over 40 years of age.
Lymphoblastic cancers are classiﬁed
as either lymphoblastic leukaemia’s or lymphoblastic lymphomas. Both are
cancers of immature lymphocytes.
Common symptoms include pallor
(paleness of skin), fatigue, bleeding, fever and recurrent infections. At the
time of diagnosis other sites outside of the lymph nodes may also be affected
and may cause symptoms such as swollen lymph nodes, enlarged liver or spleen,
neurological disturbances, enlargement of testicles in men or skin involvement.
The diagnosis is usually made by bone marrow biopsy as this typically shows
high numbers of the cancerous B-cell lymphoblast’s
How is it treated?
The treatment involves combination
chemotherapy medicines and a monoclonal antibody, and stem cell transplants when