Cov tshuaj lom neeg yog ib hom tshuaj uas muaj ib lossis ntau yam tshuaj uas ua los ntawm lossis muab rho tawm los ntawm cov hlwb lossis cov kab mob.
Biosimilar yog dab tsi?
Cov tshuaj lom neeg feem ntau yog tsim los ntawm cov proteins uas tau tsim nyob rau hauv lub cev thiab tsim los kho ntau cov qog nqaij hlav nrog rau lymphoma.
Thaum cov tshuaj lom neeg tsim tawm, cov tshuaj tau muab tso rau hauv patent. Daim ntawv patent yog daim ntawv tso cai uas muab tus thawj tsim tshuaj ntawm cov tshuaj muaj cai raug cai tsuas yog ib qho ntawm kev ua lag luam rau ntau xyoo. Thaum no patent tas sij hawm lwm lub tuam txhab tuaj yeem tsim cov tshuaj uas zoo li cov tshuaj lom neeg thiab cov no hu ua biosimilar tshuaj.
Cov tshuaj biosimilar zoo li cov tshuaj qub thiab tuaj yeem siv los kho cov kab mob tib yam li cov tshuaj lom neeg. Cov tshuaj biosimilar no tau sim thiab pom tias muaj kev nyab xeeb thiab siv tau zoo li cov tshuaj lom neeg qub.
Dab tsi biosimilars tam sim no tau siv hauv lymphoma?
Granulocyte colony stimulating factor (G-CSF)
Tam sim no muaj tsib yam tshuaj biosimilar uas tau pom zoo los ntawm TGA hauv Australia rau kev siv rau hauv qhov chaw lymphoma. Thawj cov tshuaj lom neeg yog filgrastim uas yog tsim los ntawm lub tuam txhab kws tshuaj Amgen thiab patented raws li lub npe lag luam Neupogen ™. Filgrastim yog ib hom manmade ntawm granulocyte colony stimulating factor (G-CSF) uas yog ib yam khoom tsim los ntawm lub cev los txhawb kev loj hlob ntawm neutrophils.
Raws li neutrophils yog hom ntshav dawb uas yog ib qho tseem ceeb rau lub cev tiv thaiv kab mob, filgrastim tuaj yeem muab rau cov neeg mob uas kho lawv cov qog ntshav los pab txhawb lawv cov suav neutrophil uas txo qis nrog kev kho mob uas lawv tau txais lossis ntau dua rau tsa cov neeg mob qia hlwb los ntawm cov pob txha pob txha mus rau cov ntshav peripheral rau sau rau ntawm lub tshuab apheresis. Thaum cov tshuaj lom neeg no tawm ntawm patent lwm lub tuam txhab tuaj yeem tsim cov tshuaj biosimilar thiab tam sim no muaj peb biosimilars rau filgrastim hauv Australia nrog cov npe lag luam Nivestim ™ tsim los ntawm Pfizer, Tevagrastim ™ tsim los ntawm Teva thiab Zarzio ™ tsim los ntawm Sandoz.
Rituximab
Rituximab (MabThera) yog ib qho ntawm thawj cov tshuaj tiv thaiv kab mob monoclonal kom muaj biosimilar pom zoo hauv Australia. Tam sim no muaj ob lub biosimilars rau rituximab hauv Australia nrog cov npe lag luam Riximyo tsim los ntawm Sandoz thiab Truxima ua los ntawm Celltion.
Lawv raug sim thiab pom zoo li cas?
Ib qho biosimilar dhau los ntawm kev sim dav hauv chav kuaj thiab hauv kev sim tshuaj me me los sib piv nrog cov tshuaj qub. Nws yuav tsum ua kom zoo, kev nyab xeeb, thiab kev ua haujlwm zoo (nws ua haujlwm zoo li cas).
Tom qab ntawd qhov kev sim tshuaj loj loj tau ua nyob rau hauv ib pawg neeg uas muaj tus kab mob uas tus thawj siv rau. Qhov no yog los xyuas kom meej tias qhov kev nyab xeeb thiab kev ua tau zoo yog qhov qub.
Ib qho biosimilar tsis tas yuav raug kuaj hauv txhua yam kab mob uas tus thawj pom zoo rau. Cov kev sim no tau ua tiav nrog cov tshuaj qub yog li muaj pov thawj tias cov tshuaj ua haujlwm hauv cov kab mob no. Yog tias biosimilar ua haujlwm zoo hauv 1 ntawm lawv, tsis muaj laj thawj nws yuav tsis coj zoo li lwm tus.
Vim li cas lawv thiaj li tsim?
Qhov muaj ntawm biosimilars nce kev sib tw. Kev sib tw yuav tsum txo qis tus nqi. Kev luam cov tshuaj ua tiav sai dua li tsim cov tshuaj tshiab. Tsawg dua kev sim tshuaj yog xav tau yog tias nws twb paub tias cov kab mob twg cov tshuaj ua haujlwm hauv. Biosimilars feem ntau pheej yig dua li cov tshuaj qub txawm tias cov tshuaj zoo ib yam.
Lus nug cov lus nug
Cov tshuaj Biosimilar tuaj yeem siv txawm tias koj tau kho thawj zaug nrog Biologic.
Koj lub tsev kho mob yuav hloov hom rituximab raws li biosimilars muaj. Rituximab biosimilars tsuas yog muab tso rau hauv cov hlab ntsha (los ntawm kev tso rau hauv cov hlab ntsha). Yog tias koj twb tau txhaj tshuaj rituximab, koj lub tsev kho mob yuav xav kom koj hloov cov npe yog tias xav tau. Lawv tuaj yeem hloov pauv yog tias lawv tsis muaj koj lub npe tam sim no hauv Tshuag. Koj tus kws kho mob lossis tus kws muag tshuaj tuaj yeem teb cov lus nug uas koj muaj txog kev hloov cov npe.
Tsuas yog ib hom tshuaj subcutaneous rituximab (muab los ntawm kev txhaj tshuaj hauv qab daim tawv nqaij) tam sim no muaj. Yog tias koj muaj cov kab mob subcutaneous rituximab (los ntawm kev txhaj tshuaj hauv qab ntawm daim tawv nqaij), koj yuav tau txuas ntxiv nrog qhov no rau koj txoj kev kho mob.
Tham nrog tus kws kho mob lossis tus kws saib xyuas neeg mob uas muab kev kho mob rau koj. Lawv yuav tuaj yeem teb cov lus nug uas koj muaj txog kev hloov cov npe.
Biosimilars txawv ntawm cov tshuaj generic raws li cov tshuaj generic yog tib yam active ingredient raws li cov thawj tshuaj. Ib qho piv txwv ntawm cov tshuaj generic yog thawj cov tshuaj paracetamol uas tau patented li Panadol ™ thiab cov tshuaj muaj xws li Panamax ™ thiab Herron ™ ua piv txwv.
