Hypogammaglobulinemia yog ib yam mob uas tuaj yeem cuam tshuam rau cov neeg uas muaj lymphoma. Peb B-cell lymphocytes ua cov tshuaj tiv thaiv (tseem hu ua immunoglobulins) uas pab tiv thaiv kab mob thiab kab mob.
Cov qog nqaij hlav ntawm B-cell lymphocytes, xws li B-cell lymphoma, nrog rau kev kho mob qog noj ntshav tuaj yeem ua rau cov tshuaj tiv thaiv qis hauv koj cov ntshav. Qhov no hu ua hypogammaglobulinemia thiab tuaj yeem ua rau koj muaj kab mob ntau dua lossis koj tuaj yeem muaj teeb meem tshem tawm cov kab mob.
Rau qee tus neeg, hypogammaglobulinemia yog ib qho mob ib ntus, thaum lwm tus yuav xav tau kev tiv thaiv kab mob mus ntev. Nug koj tus kws kho mob ntev npaum li cas koj yuav xav tau kev tiv thaiv kab mob ntxiv.
Ib lo lus kho mob siv los piav txog cov tshuaj tiv thaiv qis hauv koj cov ntshav.
Dab tsi yog cov tshuaj tiv thaiv?
Cov tshuaj tiv thaiv yog ib hom protein ua los ntawm peb cov B-cell lymphocytes los tua thiab tshem tawm cov kab mob thiab kab mob (cov kab mob). Peb muaj ntau hom tshuaj tiv thaiv thiab txhua tus tsuas yog sib ntaus ib hom kab mob. Nyem rau ntawm cov npe hauv qab no kom paub ntau ntxiv txog ntau hom tshuaj tiv thaiv kab mob.
Immunoglobulin Gamma
Peb muaj cov tshuaj tiv thaiv IgG ntau dua li lwm cov tshuaj tiv thaiv. Lawv zoo li tus ntawv Y .
IgG feem ntau pom hauv peb cov ntshav thiab lwm yam kua hauv lub cev. Cov proteins no muaj lub cim xeeb tiv thaiv kab mob, yog li lawv nco qab cov kab mob uas koj muaj yav dhau los thiab tuaj yeem txheeb xyuas lawv yooj yim yav tom ntej.
Txhua zaus peb muaj mob peb khaws qee qhov cim xeeb tshwj xeeb IgG hauv peb cov ntshav los tiv thaiv peb yav tom ntej.
Yog tias koj tsis muaj kev noj qab haus huv txaus IgG, koj yuav kis tau tus kab mob ntau dua lossis nyuaj rau tshem tawm cov kab mob.
Immunoglobulin Alpha (IgA)
IgA yog ib qho tshuaj tiv thaiv uas feem ntau pom nyob rau hauv peb cov mucous daim nyias nyias uas kab peb lub plab thiab ua pa ib ntsuj av. Qee qhov IgA kuj tuaj yeem nyob hauv peb cov qaub ncaug, kua muag thiab hauv cov kua mis.
IgM yog cov tshuaj tiv thaiv loj tshaj plaws uas peb muaj thiab zoo li 5 "Y" ua ke hauv cov duab ntawm lub log tsheb. Nws yog thawj cov tshuaj tiv thaiv kab mob hauv qhov chaw thaum peb muaj tus kab mob, yog li koj qib ntawm IgM tuaj yeem nce thaum muaj tus kab mob, tab sis tom qab ntawd rov qab mus rau qhov qub thaum IgG lossis lwm yam tshuaj tiv thaiv tau qhib.
Qib IgM qis tuaj yeem ua rau koj kis tau ntau dua li niaj zaus.
Immunoglobulin Epsilon (IgE)
Immunoglobulin Delta (IgD)
IgD yog ib qho ntawm cov tshuaj tiv thaiv uas nkag siab tsawg tshaj plaws. Txawm li cas los xij, qhov paub yog tias nws yog tsim los ntawm cov ntshav plasma, thiab feem ntau pom muaj txuas nrog lwm cov B-cell lymphocytes paub tab nyob rau hauv peb tus po, lymph nodes, tonsils thiab hauv ob sab phlu ntawm peb lub qhov ncauj thiab pa (mucous membranes).
Plasma cells yog daim ntawv loj tshaj plaws ntawm B-cell lymphocytes.
Ib qho me me ntawm IgD kuj tuaj yeem pom nyob rau hauv peb cov ntshav, ntsws, txoj hlab ntsws, cov kua muag kua muag thiab pob ntseg nruab nrab. IgD yog xav txhawb kom paub tab B-cell lymphocytes los ua plasma hlwb. Nws yog xav tias yog ib qho tseem ceeb ntawm kev tiv thaiv kab mob ua pa.
IgD feem ntau pom ua ke nrog IgM, txawm li cas los xij nws tsis meej txog yuav ua li cas lossis yog tias lawv ua haujlwm ua ke.
Cov tsos mob ntawm hypogammaglobulinemia
Cov tsos mob ntawm hypogammaglobulinemia muaj feem xyuam rau koj lub cev tsis muaj zog thiab kab mob uas koj tau txais.
Cov tsos mob ntawm hypogammaglobulinemia muaj xws li:
- Cov kab mob ua pa rov qab xws li mob khaub thuas, mob khaub thuas, mob ntsws, mob ntsws, COVID.
- Cov kab mob hauv koj lub plab zom mov (mob plab thiab plab hnyuv) ua rau mob plab, raws plab lossis ua pa tsw phem.
- Cov kab mob tsis zoo
- Nyuaj kis kab mob.
- Kub kub (ua npaws) ntawm 38 degrees lossis ntau dua.
- Chills thiab rigors (tshaj)
Ua rau hypogammaglobulinemia
Hypogammaglobulinemia tuaj yeem yog hom kab mob uas koj yug los vim muaj kev hloov pauv hauv koj cov noob, lossis nws tuaj yeem yog tus mob thib ob. Nplooj ntawv no yog hais txog hypogammaglobulinemia theem nrab vim nws yog ib qho kev mob tshwm sim ntawm kev kho mob es tsis yog ib qho mob uas koj yug los.
Muaj mob qog noj ntshav ntawm koj B-cell lymphocytes (xws li B-cell lymphoma) ua rau koj muaj kev pheej hmoo ntawm hypogammaglobulinemia vim nws yog B-cell lymphocytes uas ua rau peb cov tshuaj tiv thaiv. Lwm qhov laj thawj tuaj yeem suav nrog:
- Kws khomob
- Cov kab mob monoclonal
- Cov phiaj xwm kev kho mob xws li BTK lossis BCL2 inhibitors
- Kev kho hluav taws xob rau koj cov pob txha lossis pob txha pob txha
- Corticosteroids
- Kev kho mob ntawm tes xws li Stem-cell transplant lossis CAR T-cell therapy
- Noj zaub mov tsis zoo
Kev kho mob ntawm hypogammaglobulinemia
Kev kho mob ntawm hypogammaglobulinemia yog tsom rau kev tiv thaiv lossis kho txhua yam kab mob ua ntej lawv ua rau muaj kev phom sij rau lub neej.
Koj tus kws kho mob hematologist lossis tus kws kho mob oncologist yuav pib koj ntawm qee cov tshuaj prophylactic. Prophylactic txhais tau tias tiv thaiv. Cov no tau muab txawm tias koj tsis muaj kab mob, sim ua kom tsis txhob muaj mob tom qab, lossis txo koj cov tsos mob yog tias koj mob.
Qee hom tshuaj uas koj yuav tau pib muaj xws li:
- Intravenous immunoglobulin (IVIG). Qhov no tuaj yeem muab tau raws li kev txhaj tshuaj ncaj qha rau hauv koj cov hlab ntsha, lossis raws li kev txhaj tshuaj rau hauv koj lub plab. Nws tau ntim nrog immunoglobulins los ntawm tus neeg pub dawb los pab txhawb koj tus kheej immunoglobulin (antibody) qib.
- Tshuaj tiv thaiv kab mob xws li fluconazole los yog posaconazole. Cov no tiv thaiv lossis kho cov kab mob fungal xws li thrush uas koj tuaj yeem nkag mus rau hauv koj lub qhov ncauj lossis qhov chaw mos
- Cov tshuaj tiv thaiv kab mob xws li valacyclovir. Cov no tiv thaiv qhov tshwm sim los yog kho cov kab mob xws li herpes simplex virus (HSV), uas ua rau mob khaub thuas ntawm koj lub qhov ncauj lossis mob ntawm koj qhov chaw mos.
- Tshuaj tua kab mob xws li trimethoprim. Cov no tiv thaiv qee yam kab mob xws li kab mob ntsws.
Cov tsos mob ntawm tus kab mob
Cov tsos mob ntawm tus kab mob tuaj yeem suav nrog:
- Ua npaws lossis kub ntawm 38 ° degrees lossis ntau dua
- Chills thiab / los yog nruj (tsis tswj tau tshee)
- Mob thiab liab nyob ib ncig ntawm qhov txhab
- Pus los yog tawm ntawm qhov txhab
- hnoos lossis mob caj pas
- Ua tsis taus pa
- Coated tus nplaig uas tsis zoo tuaj tom qab txhuam hniav
- Mob hauv koj lub qhov ncauj uas mob thiab liab lossis mob (o)
- Nyuaj, mob lossis kub hnyiab mus rau chav dej
- Xav tias feem ntau tsis zoo
- Ntshav siab los yog lub plawv dhia ceev.
Kho mob
Yog tias koj muaj tus kab mob, koj yuav tau muab tshuaj los pab tiv thaiv tus kab mob. Qhov no tuaj yeem suav nrog tshuaj tua kab mob, tshuaj tua kab mob ntau dua lossis tshuaj tiv thaiv kab mob nyob ntawm seb hom kab mob koj muaj. Tej zaum koj yuav tau mus pw hauv tsev kho mob kom muaj cov tshuaj no.
Yog tias koj tsis zoo, lossis muaj cov tsos mob ntawm tus kab mob, hu rau koj tus kws kho mob tam sim ntawd. Yog tias koj tsis tuaj yeem tuav koj tus kws kho mob, hu xov tooj rau lub tsheb thauj neeg mob ntawm "000" lossis mus rau lub chaw kho mob xwm txheej ceev uas nyob ze tshaj plaws.
Ntsiab lus
- Hypogammaglobulinemia yog ib lo lus kho mob siv kom muaj cov tshuaj tiv thaiv qis hauv koj cov ntshav.
- Cov tshuaj tiv thaiv kuj tseem hu ua immunoglobulins thiab yog cov protein ua los ntawm B-cell lymphocyte.
- Immunoglobulins yog ib feem tseem ceeb ntawm peb lub cev tiv thaiv kab mob thiab tiv thaiv kab mob, kab mob thiab pab tshem tawm lawv ntawm peb lub cev.
- Cov tshuaj tiv thaiv kab mob qis qis tuaj yeem ua rau koj kis tau tus kab mob dua, lossis nyuaj rau kis kab mob.
- B-cell lymphomas, thiab kev kho mob rau lymphoma tuaj yeem ua rau hypogammaglobulinemia.
- Tej zaum koj yuav xav tau kev tiv thaiv kab mob ntxiv los tiv thaiv koj ntawm kev kis kab mob thiab kab mob. Qhov no yuav suav nrog kev tau txais cov tshuaj immunoglobulins los ntawm tus neeg pub dawb lossis cov tshuaj tiv thaiv kab mob tiv thaiv kab mob, tshuaj tiv thaiv kab mob lossis tshuaj tua kab mob.
- Hypogammaglobulinemia tej zaum yuav yog ib lub sijhawm luv luv lossis xav tau kev tswj xyuas mus ntev. Nug koj tus kws kho mob seb yuav xav li cas.
- Yog tias koj muaj lus nug, thov hu rau peb Cov Kws Kho Mob Lymphoma los ntawm nias rau ntawm lub pob tiv tauj peb hauv qab ntawm lub vijtsam.
