Nā Helu Lymphoma
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Hoʻoulu ʻia ka Lymphoma i ka wā e loli ai kāu mau genes ma muli o ka pōʻino a i ʻole nā hoʻololi ʻana, e hoʻomake ai i kāu maʻi e hakakā nei i nā lymphocytes a lilo i ka maʻi kanesa. Hāʻawi kā mākou mau genes i nā ʻōlelo aʻoaʻo no ka hana ʻana o kahi lymphocyte, ulu, hana, a me ka wā e make ai lākou..
Ma muli o nā hoʻololi genetic, hoʻomaka nā lymphocytes e hana hewa, no ka mea, ʻaʻole lākou e loaʻa hou nā ʻōlelo kuhikuhi mai kāu mau genes. Ma kahi o ka ulu ʻana ma ke ʻano hoʻonohonoho i ka manawa kūpono, hoʻomau lākou i ka hana ʻana i nā cell i hoʻopōʻino hou aʻe me nā genes mutated.
ʻAʻole maopopo iā mākou ke kumu o kēia. ʻAʻohe kumu maopopo o ka lymphoma a ʻaʻohe ala e haʻi ai i ka mea e loaʻa a ʻaʻole e loaʻa.
Ua ʻike ʻia kekahi mau mea pilikia, a he mau mea kēia e hoʻonui ai i kou pilikia o ka loaʻa ʻana o ka lymphoma, akā ʻaʻole ia he kumu.
He aha ka ʻokoʻa ma waena o kahi kumu pilikia a me kahi kumu?
A kumu hoʻoweliweli He mea ia e hoʻonui ai i kou manawa e loaʻa ai ka lymphoma, akā ʻaʻole ia he manaʻo e loaʻa iā ʻoe ka lymphoma.
E noʻonoʻo e pili ana i ka hailona. Inā kūʻai ʻoe i nā tiketi ʻoi aʻe ma mua o kekahi, ʻoi aku ka nui o kou manawa e lanakila ai. Akā, ʻaʻohe mea e hōʻoiaʻiʻo e lanakila ana ʻoe a, ʻo ka mea liʻiliʻi liʻiliʻi ka liʻiliʻi, akā hiki ke lanakila.
Ua like ia me nā mea pilikia. Inā loaʻa iā ʻoe kahi mea pilikia, ʻoi aku ka kiʻekiʻe wale o ka loaʻa ʻana o ka lymphoma ma mua o kekahi me ka pilikia ʻole, akā ʻaʻole ia he manaʻo e loaʻa iā ʻoe. A, no ka loaʻa ʻole o ka pilikia i kekahi, ʻaʻole ia he manaʻo e loaʻa ʻole iā lākou ka lymphoma.
No laila, ʻo ka mea pilikia e like me ka pāʻani o ka manawa.
ʻOiai inā he mea kumu he maʻi, ʻike mākou inā loaʻa kēlā mea, e hahai ana ka maʻi a inā ʻaʻole i loaʻa kēlā mea, ʻaʻohe maʻi.
Hiki iā ʻoe ke noʻonoʻo i kahi kumu e like me ka kuke ʻana i ka hua manu. Ua ʻike mākou inā ʻoe e uhaʻi i ka hua manu, e hoʻokomo i loko o ka pā a hoʻonui i ka wela e moʻa ai. Akā, inā wehe ʻoe, hoʻokomo i loko o ka pā akā ʻaʻole e hoʻā i ka wela, noho ka hua ma laila ʻaʻole e moʻa.
ʻO ka wela ka mea e moʻa ai ka hua. ʻAʻole ia he kumu pilikia, no ka mea, i kēlā me kēia manawa āu e hoʻohuli ai i ka wela ma kēia kūlana, e moʻa ka hua, a i kēlā me kēia manawa ʻaʻohe wela, ʻaʻole e moʻa ka hua.
Kauka Mary Ann Anderson - Heamatologist mai
ʻO Peter MacCallum Cancer Center & Royal Melbourne Hospital e kamaʻilio e pili ana i ke kumu e ulu ai ka lymphoma.
He aha nā mea pilikia i ʻike ʻia?
Ma lalo ʻoe e ʻike ai i nā mea pilikia i ʻike ʻia e hoʻonui i kou manawa e loaʻa ai ka lymphoma a i ʻole CLL. ʻAʻole pili nā mea pilikia a pau i nā ʻano subtypes o lymphoma. Inā loaʻa kahi subtype kikoʻī e pili ana i nā kumu pilikia a mākou i hoʻohui ai i ka subtype.
Inā makemake ʻoe e aʻo hou e pili ana i kāu subtype, hiki iā ʻoe ke kaomi i ka loulou ma lalo nei. A i ʻole, e kaomi i ka pua ma ka ʻaoʻao o nā kumu pilikia ma lalo nei e aʻo hou aku.
E like me kāu e ʻike ai mai ka hae ma luna o ka ʻaoʻao, ʻo ka lymphoma ka maʻi maʻi maʻamau i nā ʻōpio a me nā ʻōpio makua ma waena o 15-29 mau makahiki. ʻOi aku ka maʻamau o Hodgkin Lymphoma i kēia pūʻulu makahiki, akā hiki nō iā lākou ke loaʻa i ka Non-Hodgkin Lymphoma. ʻO Lymphoma ka 3 o ka maʻi maʻi maʻamau i nā keiki ma lalo o 15 mau makahiki.
Eia naʻe, piʻi ka pilikia o ka loaʻa ʻana o ka lymphoma me ka makahiki. ʻO ka hapa nui o nā kānaka me lymphoma a i ʻole CLL he 60 mau makahiki a ʻoi paha.
ʻAʻole i hoʻoili ʻia mai ka Lymphoma mai kou mau mākua mai, akā, inā he lālā ʻohana kou me ka lymphoma a i ʻole CLL e piʻi aʻe paha ʻoe i ka hoʻomohala ʻana.
ʻAʻole kēia ma muli o ka maʻi ʻohana, akā no ka mea hiki ke ʻike ʻia nā ʻohana i nā ʻano mea pilikia - e like me nā kemika a i ʻole nā maʻi. a i ʻole nā maʻi ʻōnaehana pale e holo i loko o nā ʻohana.
Mālama ko mākou ʻōnaehana pale iā mākou mai nā maʻi a me nā maʻi, a kōkua pū hoʻi i ka hoʻoponopono ʻana a me ka luku ʻana i nā cell i hōʻino ʻia a i ʻole ke kanesa. Inā ua kipa mua ʻoe i kā mākou ʻaoʻao pūnaewele ma Ma ka hoʻomaopopo ʻana i kāu ʻōnaehana lymphatic a me ka immune, hiki iā ʻoe ke nānā iā ia ma ke kaomi ʻana ma aneʻi.
Inā loaʻa iā ʻoe kahi ʻōnaehana pale pale - ʻo ia hoʻi ʻaʻole ia e hana e like me ka mea e pono ai, e piʻi aʻe paha ʻoe i ka maʻi a me ka ulu ʻana o ka lymphoma.
ʻO nā mea e hiki ke hoʻopau i kāu ʻōnaehana immune e pili ana i kēia.
Nā lāʻau immunosuppressive a me nā lāʻau lapaʻau
Inā ʻoe e lawe ana i ka lāʻau no ka hoʻopau ʻana i kāu ʻōnaehana pale, hiki ke hoʻonui i kou pilikia o ka hoʻomohala ʻana i ka lymphoma a me nā maʻi maʻi ʻē aʻe. ʻO nā laʻana o kēia mau lāʻau lapaʻau i lawe ʻia no nā maʻi autoimmune, a i ʻole ma hope o ka hoʻololi ʻana o ke kino a i ʻole ka hoʻololi ʻana i ke ʻano o ke ʻano o ke ʻano allogeneic. ʻO nā Lymphomas e ulu ana ma hope o ka hoʻololi ʻana ua kapa ʻia ʻo "Post-Transplant Lymphoproliferative Disorder (PTLD)".
Hiki i nā lāʻau lapaʻau kemoterapi a me nā lāʻau lapaʻau ʻē aʻe e like me ka radiotherapy a me kekahi mau antibodies monoclonal hiki ke hoʻopau i kāu ʻōnaehana pale.
E kamaʻilio mau me kāu kauka e pili ana i nā pilikia i loaʻa mai i kāu mau lāʻau lapaʻau a me nā lāʻau lapaʻau ʻē aʻe.
Nā maʻi Immunodeficiency
ʻO nā maʻi immunodeficiency nā maʻi o kāu ʻōnaehana pale. Hiki ke hānau ʻia nā kānaka me kēia mau maʻi a loaʻa iā lākou ma hope o ke ola.
ʻO nā maʻi immune mua ka mea āu i hānau ai a hiki ke komo pū:
- ʻO ka immunodeficiency pili X-pili
- Ataxia Telangiectasia
- ʻO ka maʻi maʻi Wiskott-Aldrich.
ʻO nā maʻi immunodeficiency lua he mau kūlana i loaʻa iā mākou i ko mākou ola ʻana, a i ʻole ma muli o kekahi kumu ʻē aʻe - e like me ke kumu o ka chemotherapy. neutropenia e alakaʻi ana i ka nele o ka immune. ʻO ka loaʻa ʻana o ka maʻi maʻi ʻole o ka maʻi (AIDS) kekahi ʻano o ka maʻi maʻi ʻole o ke kino lua, ka mea maʻamau i hoʻokumu ʻia e ka maʻi maʻi immunodeficiency kanaka (HIV).
ʻO nā maʻi Autoimmune
ʻO nā maʻi autoimmune nā kūlana kahi e hoʻomaka ai kāu ʻōnaehana pale e hoʻouka i kāu mau sela olakino. Nui nā ʻano maʻi autoimmune, a ua ʻike ʻia kekahi i ka hoʻonui ʻana i kou pilikia o kekahi mau subtypes o lymphoma e like me:
- Sjogren's Syndrome - hoʻonui i ka pilikia o splenic a me MALT marginal zone lymphomas.
- ʻO ka thyroiditis o Hashimoto - hoʻonui i ka pilikia o MALT marginal zone lymphoma.
- ʻO ka maʻi Celiac - hoʻonui i ka pilikia o Enteropathy-Associated T-Cell Lymphoma (EATL), ʻo ia ka subtype o ʻO Lymphoma T-Cell ʻAʻe (PTCL)
- Rheumatoid arthritis - hoʻonui i ka pilikia o Splenic Marginal Zone Lymphoma a Hoʻohui i ka Lymphoma B-Cell nui.
Hiki i kekahi mau maʻi ke hoʻonui i kou pilikia o ka hoʻomohala ʻana i ka lymphoma. ʻO ka pinepine kēia mau maʻi i loaʻa iā mākou i ka wā kamaliʻi a he nui nā mea hiki ʻole ke pale ʻia. ʻOiai hiki i kēia mau maʻi ke hoʻonui i kou pilikia o ka loaʻa ʻana o ka lymphoma ma hope o ke ola, nui ka poʻe i loaʻa i kēia mau maʻi ʻaʻole e ulu i ka lymphoma, a ʻo ka poʻe i loaʻa ʻole i kēia maʻi hiki ke loaʻa i ka lymphoma.
Virus Epstein-Barr (EBV)
Ua ʻike ʻia ʻo EBV he kumu pilikia no nā ʻano subtypes like ʻole o ka lymphoma. He ʻano ia o ka maʻi herpes hiki ke hoʻololi i ke ʻano o ka hana ʻana o kā mākou B-cell. ʻO EBV ka maʻi maʻi e hoʻoulu ai i ka maʻi maʻi glandular, a i kapa ʻia hoʻi i kekahi manawa ʻo ka "maʻi honi" no ka mea hiki ke hele i loko o ka saliva. Ua kapa ʻia ʻo ia i kekahi manawa he mononucleosis a i ʻole "mono". ʻO kekahi mau subtypes o lymphoma e pili ana me EBV penei:
- ʻO Burkitt Lymphoma
- Diffuse Lymphoma B-nui
- Hodgkin Lymphoma
- T-cell Lymphomas
- ʻO ka maʻi lymphoproliferative post transplant ma hope o kahi ka hoʻololi ʻana i ke ʻano o ke ʻano o ke ʻano allogeneic.
Helicobacter Pylori (H. Pylori)
ʻO H. Pylori kahi maʻi e hoʻoulu ai i ka ʻōpū o ka ʻōpū, a hoʻonui i kou pilikia o ka ulu ʻana ʻO ka maʻi maʻi MALT Marginal Zone Lymphoma.
Campylobacter jejuni & Borrelia burgdorferi
ʻO Campylobacter jejuni ka maʻi bacteria e hoʻoulu pinepine ai i ka ʻai ʻana me nā hōʻailona maʻamau ʻo ke kuni a me ka maʻi maʻi. ʻO Borrelia burgdorferi kahi maʻi bacteria e hoʻoulu ai i ka maʻi Lyme.
Hiki i kēia mau maʻi bacteria ʻelua ke hoʻonui i kou pilikia o ka ulu ʻana MALT Marginal Zone Lymphoma.
ʻO ke kanaka T-lymphotropic virus ʻano 1 a me 2
He kakaikahi kēia maʻi maʻi ma Australia a ʻoi aku ka maʻamau ma ka ʻaoʻao hema o Iapana a me ka Caribbean akā naʻe, loaʻa nō ia ma kekahi mau wahi o Australia. Hoʻolaha ʻia ia ma o ka moe kolohe ʻole ʻana me ke kanaka me ka maʻi maʻi, ke koko haumia a i ʻole nā nila a ma o ka waiū umauma. Hiki i ke kanaka T-lymphotropic virus ke hoʻonui i kou pilikia o ka hoʻomohala ʻana i kahi subtype o lymphoma i kapa ʻia Leukemia/Lymphoma makua T-cell.
ʻUslelo Hōʻea A Nā Puʻuhonua (HIV)
ʻO ka maʻi HIV ka maʻi e hiki ai ke hoʻoulu i ka Acquired Immune Deficiency Syndrome (AIDS). Lawe ʻia ia ma o ka moe kolohe ʻole ʻana me kekahi me ka maʻi maʻi, ke koko a me nā nila i hoʻohaumia ʻia, a i kekahi manawa mai ka makuahine a i ke keiki i ka wā hāpai, hānau ʻana a hānai ʻana paha. Hiki i ka loaʻa ʻana o ka maʻi HIV ke hoʻonui i kou pilikia o nā Lymphomas Hodgkin a me Non-Hodgkin Lymphomas. ʻO nā lymphoma e pili ana i ka maʻi HIV a i ʻole AIDS he mea koʻikoʻi me nā lymphomas pili i ka AIDS maʻamau Hoʻohui i ka Lymphoma B-Cell nui a ʻO Burkitt Lymphoma, ʻoiai hiki ke hoʻonui i kou pilikia o ʻO Lymphoma Pūnaewele Nervous Kūmua a me ka Lymphoma Effusion Primary.
Human Herpesvirus-8 (HHV8) – kapa ʻia ʻo Kaposi Sarcoma Herpesvirus (KSHV)
Kapa ʻia ʻo HHV8 ʻo Kaposi Sarcoma Herpesvirus no ka mea hiki iā ia ke hoʻoulu i ka sarcoma Kaposi, ʻo ia ka maʻi maʻi kakaʻikahi o ke koko a me nā kīʻaha lymph. Eia nō naʻe, ua ʻike ʻia ʻo ia he kumu pilikia no ka hoʻomohala ʻana i kahi lymphoma subtype loa i kapa ʻia ʻo Primary Effusion Lymphoma.
Hepatitis C Virus (HCV)
ʻO ka HCV kahi maʻi e hoʻomake ai i kou ate. Hiki iā ia ke hoʻoulu i kahi maʻi i kapa ʻia ʻo cryoglobulinemia e hiki ke hopena i ka ulu ʻole ʻana o nā cell - akā ʻaʻole ia he maʻi kanesa. Eia naʻe, hiki ke loli i ka manawa a lilo i ka maʻi kanesa, e hoʻonui ana i kou pilikia B-cell Non-Hodgkin Lymphomas.
Ua ʻike ʻia ka ʻike ʻana i kekahi mau kemika ma ke ʻano he kumu pilikia no ka Lymphoma Hodgkin a me nā ʻano like ʻole o Non-Hodgkin Lymphomas. Hoʻonui ʻia kou pilikia inā hoʻohana ʻoe a hana paha i kēia mau huahana.
Hiki paha iā ʻoe ke piʻi aʻe ka pilikia o ka hoʻomohala ʻana i ka lymphoma inā ʻoe e hana ma nā wahi e hoʻohana a mea hana paha i nā huahana e like me:
- pesticides
- herbicides
- piliwaiwai
- nā mea lele
- nā mea hoʻoheheʻe
- ʻopi
- nā mea puhi
- ʻaila
- lepo
- kala lauoho.
Inā ʻoe e hana ma kēia mau wahi he mea nui e hoʻohana ʻoe i nā lako pale pilikino i ʻōlelo ʻia no kāu ʻoihana a me kāu huahana.
Ua manaʻo kekahi mau noiʻi e piʻi aʻe paha ka pilikia o ka poʻe mahiʻai, nā mea hana lāʻau, nā mea nānā ʻiʻo a me nā kauka holoholona, akā naʻe, pono ka noiʻi hou e hōʻoia i kēia.
Anaplastic Large Cell Lymphoma pili i ka umauma implant
Ua ʻike ʻia nā mea implants ma ke ʻano he kumu pilikia no ka ulu lohi (indolent) subtype o T-cell Non-Hodgkin Lymphoma i kapa ʻia ʻo Anaplastic Large Cell Lymphoma (ALCL). ʻOi aku ka maʻamau ma kahi i hoʻohana ʻia ai nā implants textured ma mua o nā implants maʻalahi.
ʻOiai hoʻomaka kēia maʻi kanesa ma ka umauma, ʻaʻole ia he ʻano o ka maʻi maʻi umauma. Ua manaʻo ʻia ma muli o nā ʻeke o ka wai, ka maʻi a i ʻole ka mumū e kūkulu ʻia ana a puni ka implant a hiki i ka manawa ke hoʻololi i ALCL. Inā loaʻa iā ʻoe ka ALCL pili i ka umauma implant, e ʻōlelo aku kāu kauka e hana ʻoe i kahi hana e wehe ai i ka implant a me kekahi wai a i ʻole ka maʻi i loaʻa. ʻO kēia wale nō paha ka lāʻau lapaʻau āu e pono ai, akā inā ua laha i nā wahi ʻē aʻe o kou kino, e ʻōlelo ʻia ʻoe i nā lāʻau lapaʻau ʻē aʻe. Hiki iā ʻoe ke aʻo hou e pili ana i kēia ma ke kaomi ʻana i ka loulou ma lalo nei.
Hoʻolāʻau maʻi
ʻO ka mea pōʻino, ʻo ka nui o nā lāʻau lapaʻau i hoʻohana ʻia no ka mālama ʻana i ka maʻi kanesa hiki ke hoʻoulu i nā maʻi maʻi lua. 'A'ole like kēia mau ma'i 'a'ai me ka ma'i 'a'ai mua a 'a'ole i mana'o 'ia he ma'i 'a'ai. ʻO ka pilikia o ka hoʻomohala ʻana i kahi maʻi maʻi lua e like me ka lymphoma e mau ana no nā makahiki he nui ma hope o kāu mālama ʻana.
ʻO nā lāʻau lapaʻau e like me ka chemotherapy, radiotherapy a me nā lāʻau lapaʻau ʻē aʻe e hoʻopau i kou ʻōnaehana pale, a i ʻole e hōʻino i kāu lymphocytes e hoʻonui i kou pilikia o ka ulu ʻana i ka lymphoma.
Inā mālama ʻoe i kekahi ʻano maʻi maʻi e like me ka lymphoma, e nīnau i kāu kauka e pili ana i ka pilikia o nā maʻi maʻi lua.
Monoclonal B-cell lymphocytosis
ʻO ka Monoclonal B-cell lymphocytosis (MBL) kahi maʻi maʻi ʻole e hoʻonui i ka nui o nā lymphocytes B-cell maʻamau i loko o ke koko. Loaʻa nā ʻano like ʻole o nā B-lymphocytes me ka maʻi maʻi lymphocytic maʻi (CLL), kahi subtype o Non-Hodgkin Lymphoma.
Manaʻo ʻia ʻo MBL he maʻi pre-cancerous hiki ke hoʻololi i CLL i ka manawa. Eia naʻe, ʻaʻole nā kānaka a pau me MBL e hoʻomohala iā CLL.
He kakaikahi loa ka MBL i nā poʻe ma lalo o 40 mau makahiki a ʻo ka pilikia o ka hoʻomohala ʻana i ka MBL e hoʻonui i ko mākou mau makahiki.
Aloha Hawaii
'A'ole like me nā ma'i ma'i 'ē a'e, he mau hō'ike li'ili'i loa e hō'ike ana i ka lymphoma ma muli o nā koho ola. Eia nō naʻe, hiki i kekahi mau koho (e like me ka hoʻomaʻemaʻe maikaʻi ʻole, ka wahine pale ʻole a i ʻole ka launa pū ʻana i nā nila) hiki ke hoʻonui i kou pilikia o ka loaʻa ʻana o kekahi mau maʻi maʻi a me nā maʻi ʻē aʻe, aʻo nā mea ʻē aʻe (e like me ka hoʻomaʻamaʻa kino ʻole, a i ʻole ka meaʻai maikaʻi ʻole) hiki ke hoʻemi i kāu hana pale. ʻO kēia mau maʻi, a i ʻole ka pale ʻana i ka immune hiki ke hoʻonui i kou pilikia o ka hoʻomohala ʻana i ka lymphoma.
ʻO ka mālama ʻana i ke ʻano ola olakino hiki ke hōʻemi i kou pilikia o ka loaʻa ʻana o ka lymphoma, ʻoiai ʻaʻohe mea hōʻoia. Nui ka poʻe i loaʻa i ka lymphoma e ola i ke ola olakino. Eia nō naʻe, ʻoiai ʻaʻole hiki i kāu mau koho ʻana i ke ola ke pale pono iā ʻoe mai ka loaʻa ʻana o ka lymphoma, no ke olakino ʻē aʻe inā pono ʻoe e hoʻomaka i ka mālama ʻana, e kōkua i kou kino e hoʻokō maikaʻi a ola wikiwiki.
ʻO kekahi mau koho olakino e noʻonoʻo ai:
- Mai hoʻomaka i ka puhi paka, a i ʻole loaʻa ke kōkua e haʻalele.
- Hōʻalo i nā lāʻau lapaʻau.
- Inā pono ʻoe e hoʻohana i nā nila no kekahi kumu, e hoʻohana iā lākou i hoʻokahi manawa a waiho i loko o kahi pahu kūpono e hoʻopau ai. Mai kaʻana like i nā nila me nā poʻe ʻē aʻe.
- Inā inu ʻoe i ka waiʻona, inu ʻoe me ka liʻiliʻi.
- E ʻimi no ka liʻiliʻi o 30 mau minuke o ka hoʻoikaika kino i kēlā me kēia lā. Inā paʻakikī ka hoʻoikaika kino iā ʻoe, e ʻike iā ʻoe i ke kauka kūloko.
- E ʻai i ka meaʻai olakino. Inā makemake ʻoe i kōkua me kēia, hiki i kāu kauka kūloko ke kuhikuhi iā ʻoe i kahi meaʻai meaʻai.
- E leʻaleʻa, akā e palekana i ka hana.
hōʻuluʻulu manaʻo
- Hoʻomaka ka Lymphoma i ka wā e hoʻololi ai - i kapa ʻia hoʻi nā hoʻololi ʻana i kāu mau genes e pili ana i ke ʻano o ka ulu ʻana a me ka hana o kāu lymphocytes.
- ʻAʻohe kumu i ʻike ʻia no kēia hoʻololi e alakaʻi ai i ka lymphoma.
- Hiki i nā mea pilikia ke hoʻonui i kou manawa e loaʻa ai ka lymphoma, akā, ʻo ka loaʻa ʻana o kahi kumu pilikia, ʻaʻole ia he manaʻo e loaʻa iā ʻoe ka lymphoma.
- ʻO ka loaʻa ʻole o kahi kumu pilikia ʻaʻole ia he manaʻo e loaʻa ʻole ʻoe i ka lymphoma.
- ʻAʻole ʻo Lymphoma kahi maʻi maʻi maʻi "ʻano ola" - ʻaʻole ia ma muli o ke koho ʻana i ka nohona e like me nā maʻi maʻi ʻē aʻe.
