ʻO ka lāʻau lapaʻau olaola he lāʻau i loaʻa i hoʻokahi a ʻoi aʻe nā mea hana i hana ʻia e a i ʻole i unuhi ʻia mai nā sela ola a i ʻole nā mea ola.
He aha ka Biosimilar?
Hana ʻia nā lāʻau lapaʻau olaola me nā polokina i hana maoli ʻia i loko o ke kino a hoʻomohala ʻia no ka mālama ʻana i nā maʻi maʻi he nui me ka lymphoma.
Ke hana ʻia kahi lāʻau olaola, waiho ʻia ka lāʻau ma lalo o ka patent. ʻO ka patent kahi laikini e hāʻawi i ka mea nāna i hoʻokumu i ka lāʻau lapaʻau i ke kuleana kānāwai e lilo i hoʻokahi wale nō ma ka mākeke no kekahi mau makahiki. Ke pau kēia patent, hiki i nā hui ʻē aʻe ke hana i nā lāʻau lapaʻau e like me ka lāʻau lapaʻau ola mua a ua kapa ʻia kēia mau lāʻau biosimilar.
ʻO nā lāʻau biosimilar e like me ka lāʻau lapaʻau mua a hiki ke hoʻohana ʻia e mālama i nā maʻi like e like me nā lāʻau olaola. Ua hoʻāʻo ʻia kēia mau lāʻau biosimilar a ua hōʻike ʻia he palekana a maikaʻi hoʻi e like me nā lāʻau lapaʻau kumu.
He aha nā biosimilars e hoʻohana ʻia nei i ka lymphoma?
ʻO ka mea hoʻoulu ʻia ʻo Granulocyte colony stimulating factor (G-CSF)
Aia i kēia manawa ʻelima mau lāʻau biosimilar i ʻae ʻia e ka TGA ma Australia no ka hoʻohana ʻana i ka hoʻonohonoho lymphoma. ʻO ka lāʻau lapaʻau ola mua ʻo filgrastim i hana ʻia e ka hui lāʻau lapaʻau ʻo Amgen a hoʻopaʻa ʻia ma lalo o ka inoa kālepa Neupogen™. ʻO Filgrastim kahi ʻano hana kanaka o granulocyte colony stimulating factor (G-CSF) he mea ia i hana ʻia e ke kino e hoʻoulu i ka ulu ʻana o nā neutrophils.
No ka mea, he ʻano o ke koko keʻokeʻo keʻokeʻo ka neutrophils i mea nui no ka hakakā ʻana o ke kino i ka maʻi, hiki ke hāʻawi ʻia ka filgrastim i nā poʻe maʻi e mālama ana i ko lākou lymphoma e kōkua i ke kākoʻo ʻana i kā lākou helu neutrophil i hoʻohaʻahaʻa ʻia me ka lāʻau lapaʻau e loaʻa ana iā lākou. e hoʻoneʻe i nā mea maʻi mai ka iwi iwi a i ke koko ʻaoʻao no ka ʻohi ʻana ma ka mīkini apheresis. I ka wā i puka mai ai kēia lāʻau olaola mai ka patent, ua hiki i nā hui ʻē aʻe ke hana i kahi lāʻau biosimilar a i kēia manawa aia ʻekolu biosimilars no ka filgrastim ma Australia me nā inoa kālepa Nivestim ™ i hana ʻia e Pfizer, Tevagrastim ™ i hana ʻia e Teva a me Zarzio ™ i hana ʻia e Sandoz.
ʻO Rituximab
ʻO Rituximab (MabThera) kekahi o nā antibodies monoclonal paʻakikī i loaʻa i kahi biosimilar i ʻae ʻia ma Australia. Aia i kēia manawa ʻelua biosimilars no rituximab ma Australia me nā inoa kālepa Riximyo i hana ʻia e Sandoz a me Truxima i hana ʻia e Celltrion.
Pehea lākou e hoʻāʻo ʻia ai a ʻae ʻia?
Hele ka biosimilar i nā hoʻokolohua nui i loko o kahi keʻena hoʻokolohua a me nā hoʻokolohua liʻiliʻi liʻiliʻi e hoʻohālikelike me ka lāʻau lapaʻau mua. Pono e kūlike i ka maikaʻi, ka palekana, a me ka maikaʻi (pehea ka hana ʻana).
A laila lawe ʻia kahi hoʻokolohua lapaʻau nui i kahi hui o nā poʻe me kahi maʻi i hoʻohana ʻia no ka mea kumu. ʻO kēia ka mea e hōʻoia i ka palekana a me ka maikaʻi e kūlike me ka mea kumu.
ʻAʻole pono e hoʻāʻo ʻia kahi biosimilar i kēlā me kēia maʻi i ʻae ʻia ka mea kumu. Ua hana ʻia kēia mau hoʻāʻo ʻana me ka lāʻau lapaʻau kumu no laila ua ʻike mua ʻia ka hana o ka lāʻau i kēlā mau maʻi. Inā hana maikaʻi ka biosimilar i ka 1 o lākou, ʻaʻohe kumu e hana like ʻole ai ia i nā mea ʻē aʻe.
No ke aha lākou i kūkulu ʻia ai?
ʻO ka loaʻa ʻana o nā biosimilars e hoʻonui i ka hoʻokūkū. Pono ka hoʻokūkū e hoʻohaʻahaʻa i nā kumukūʻai. ʻOi aku ka wikiwiki o ke kope ʻana i ka lāʻau lapaʻau maikaʻi ma mua o ka hoʻomohala ʻana i kahi lāʻau lapaʻau hou. Pono nā hoʻokolohua lapaʻau liʻiliʻi inā ʻike mua ʻia nā maʻi o ka lāʻau lapaʻau.
Pinepine ninau ninau
Hiki ke hoʻohana ʻia nā lāʻau lapaʻau biosimilar inā ua mālama mua ʻia ʻoe me ka Biologic.
Hiki i kāu haukapila ke hoʻololi i nā hōʻailona o rituximab ke loaʻa nā biosimilars. Hāʻawi ʻia nā biosimilars Rituximab i loko o ka vein wale nō (ma ke kahe ʻana i loko o kahi vein). Inā loaʻa iā ʻoe ka rituximab intravenous, makemake paha kou haukapila iā ʻoe e hoʻololi i nā hōʻailona inā pono. Hiki iā lākou ke hoʻololi inā ʻaʻole i loaʻa iā lākou kāu hōʻailona o kēia manawa. Hiki i kāu kauka a lāʻau lapaʻau paha ke pane i nā nīnau āu e pili ana i ka hoʻololi ʻana i nā hōʻailona.
Hoʻokahi wale nō hōʻailona o subcutaneous rituximab (i hāʻawi ʻia e ka ʻinikua ma lalo o ka ʻili) i loaʻa i kēia manawa. Inā loaʻa iā ʻoe ka rituximab subcutaneous (ma ka ʻinikua ma lalo o ka ʻili), e hoʻomau paha ʻoe i kēia no kāu papa o ka mālama ʻana.
E kamaʻilio me ke kauka a kahu hānai paha nāna e mālama iā ʻoe. Hiki iā lākou ke pane i nā nīnau āu e pili ana i ka hoʻololi ʻana i nā hōʻailona.
ʻOkoʻa nā biosimilars mai nā lāʻau lapaʻau maʻamau no ka mea ʻo nā lāʻau lapaʻau maʻamau ka mea hana like me ka lāʻau kemika kumu. ʻO kahi laʻana o ka lāʻau lapaʻau maʻamau ka paracetamol lāʻau kemika mua i hoʻopaʻa ʻia e like me Panadol ™ a ʻo nā lāʻau lapaʻau maʻamau ka Panamax ™ a me Herron ™ ma ke ʻano he laʻana.
