Hoʻohana pinepine ʻia ka lāʻau mālama mālama me kekahi mau ʻano lymphoma me ka manaʻo e mālama i ka lymphoma i ke kala ʻana no ka lōʻihi.
He aha ka mālama mālama?
ʻO ka hoʻomaʻamaʻa mālama ʻana e pili ana i ka mālama mau ʻana ma hope o ka hoʻomaʻamaʻa mua ʻana i ka lymphoma i kala ʻia (ua emi ka lymphoma a ua pane paha i ka lāʻau lapaʻau). ʻO ka pahuhopu e hoʻomau i ke kala ʻana e like me ka hiki. ʻO ke ʻano maʻamau o ka lāʻau lapaʻau i hoʻohana ʻia i ka mālama ʻana me kahi antibody (e like me Rituximab a i ʻole Obinutuzumab).
Hoʻohana ʻia ka Chemotherapy i kekahi manawa ma ke ʻano he mālama mālama no nā keiki a me nā ʻōpio me lymphoma lymphoblastic. Hoʻomaka ʻia lākou i loko o nā mahina 6 mua ma hope o ka mālama mua ʻana e mālama i ka lymphoma mai ka holomua ʻana a i ʻole ka hoʻi hou ʻana.
Pehea ka lōʻihi o ka mālama mālama ʻana?
Ma muli o ke ʻano o ka lymphoma a me nā lāʻau lapaʻau i hoʻohana ʻia, hiki ke mālama ʻia ka mālama mālama no nā pule, mahina, a i ʻole mau makahiki. ʻAʻole ʻōlelo ʻia nā poʻe maʻi āpau e mālama i ka mālama mālama inā mālama ʻia ko lākou lymphoma ma hope o ka mālama ʻana. Ua ʻike ʻia he mau pōmaikaʻi i kekahi mau subtypes o lymphoma.
ʻO Rituximab kahi antibody monoclonal i ʻōlelo pinepine ʻia e like me ka mālama mālama ʻana i nā maʻi me nā ʻano like ʻole o ka lymphoma non-Hodgkin (NHL). Ua loaʻa pinepine kēia mau maʻi i ka rituximab ma ke ʻano he ʻāpana o kā lākou induction therapy, i hui pū ʻia me ka chemotherapy (i kapa ʻia chemoimmunotherapy).
Inā pane ka lymphoma i ka mālama mua ʻana, hiki ke ʻōlelo ʻia ka rituximab e hoʻomau ʻia ma ke ʻano he 'maintenance therapy'. Hoʻohana ʻia ka rituximab i ka manawa mālama i hoʻokahi manawa i kēlā me kēia 2-3 mahina. Hāʻawi ʻia ʻo Rituximab i kēia manawa no ka lōʻihi o 2 mau makahiki, ʻoiai ke hoʻāʻo nei nā hoʻokolohua lapaʻau inā loaʻa kekahi pōmaikaʻi o ka mālama mālama ʻana e hoʻomau ʻia no ka lōʻihi. No ka mālama ʻana i ka lāʻau lapaʻau, hiki ke hāʻawi ʻia ka rituximab i ka intravenously (ma ke kī ʻia i loko o kahi vein) a i ʻole subcutaneously (ma ke kī ʻia ma lalo o ka ʻili).
ʻO kahi ʻē aʻe, ʻo Obinutuzumab (Gazyva) kahi antibody monoclonal i hoʻohana ʻia no ka mālama ʻana i nā maʻi me ka follicular lymphoma post chemotherapy. Hoʻohana ʻia ka Obinutuzumab i kēlā me kēia 2 mahina no 2 mau makahiki.
ʻO wai ka mea e loaʻa i ka mālama mālama?
Ua hoʻohana nui ʻia ka rituximab mālama i nā subtypes NHL indolent e like me ka follicular lymphoma. Ke nānā ʻia nei ka lāʻau mālama mālama ma nā ʻano subtypes o nā lymphomas. Hiki ke mālama ʻia nā keiki a me nā poʻe ʻōpio me ka lymphoblastic lymphoma me ka chemotherapy e pale ai i ka hoʻi hou ʻana o ko lākou lymphoma. ʻO kēia kahi papa hana ʻoi loa o ka chemotherapy.
He aha nā pōmaikaʻi o ka mālama mālama?
ʻO ka loaʻa ʻana o ka lāʻau mālama mālama me rituximab a i ʻole Obinutuzumab hiki ke hoʻonui i ka lōʻihi o ke kala ʻana i nā poʻe maʻi me ka lymphoma follicular a mantle cell. Ua hōʻike ʻia ka noiʻi e hiki ke hoʻopanee a pale ʻia paha ka hoʻihoʻi ʻana, ma ka hoʻomau ʻana a i ʻole ka mālama ʻana i ka mālama ʻana me rituximab i ka wā e kala ana nā maʻi. ʻO ka pahuhopu ka pale ʻana i ka poʻe maʻi i pane i ka lāʻau lapaʻau mua mai ka hoʻi hou ʻana i ka wā e hoʻomaikaʻi ai i ke ola holoʻokoʻa. Ma Australia, ʻo kēia wale nō ke kālā kālā (PBS) no rituximab i ka lymphoma follicular.
ʻO nā pilikia o ka mālama mālama
ʻOiai ʻo nā lāʻau lapaʻau i hoʻohana ʻia no ka mālama mālama ʻana he liʻiliʻi nā hopena ʻaoʻao ma mua o ka hoʻohui ʻana i ka chemotherapy, hiki i nā maʻi ke loaʻa i nā hanana ʻino mai kēia mau lapaʻau. E noʻonoʻo ke kauka i nā kūlana lapaʻau āpau ma mua o ka hoʻoholo ʻana i ka lāʻau lapaʻau mua a inā paha e pōmaikaʻi ka mea maʻi mai ka mālama mālama ʻana me kahi lapaʻau ʻē aʻe a i ʻole 'nānā a kali'.
ʻAʻole i loaʻa i ka hapa nui o nā maʻi nā hopena ʻaoʻao pilikia ma ka rituximab. Eia naʻe, ʻaʻole kūpono i nā mea a pau ke loaʻa i ka mālama mālama. ʻO kekahi o nā hopena ʻaoʻao o ka mālama ʻana iā Rituximab:
- Ka hopena hoʻowali
- Hoʻohaʻahaʻa i nā hopena ma nā ʻāpana koko
- ʻO ke poʻo a i ʻole nā hōʻailona like me ka flu
- Kalohi a maule
- ʻO nā loli o ka ʻili e like me ka ʻili
ʻO nā lāʻau lapaʻau i hoʻokolokolo ʻia e like me ka mālama mālama
Ke hoʻāʻo ʻia nei ka nui o nā mea hou a me nā lāʻau lapaʻau hui a puni ka honua no kā lākou hoʻohana ʻana i ka mālama mālama ʻana no ka lymphoma. ʻO kekahi o kēia mau lāʻau lapaʻau penei:
- Bortezomib (Velcade)
- Brentuximab vedotin (Adcetris)
- Lenalidomide (Revlimid)
- Vorinostat (Zolinza)
Ke ulu mau nei ka noiʻi ʻepekema. Hiki ke loli nā koho lapaʻau ke ʻike ʻia nā lāʻau lapaʻau hou a hoʻomaikaʻi ʻia nā koho lapaʻau.
ʻIke hou aku
Hiki iā ʻoe ke komo i ka ʻike hou aku e pili ana i ka mālama mālama ʻana āu e loaʻa nei ma ka hahai ʻana i nā loulou ma lalo nei:
